{"EMPIAR-11711":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame micrographs of human DNA polymerase θ helicase domain bound to inhibitor AB25583","directory":"data/20230223_USC_fumiakii_f4_polQ-H_grid4","category":"micrographs - multiframe","header_format":"EER","data_format":"EER","num_images_or_tilt_series":4500,"frames_per_image":2051,"frame_range_min":null,"frame_range_max":null,"voxel_type":"BIT","pixel_width":0.92,"pixel_height":0.92,"micrographs_file_pattern":"data/20230223_USC_fumiakii_f4_polQ-H_grid4/Images-Disc1/*/*/*.eer","picked_particles_file_pattern":"","picked_particles_directory":"","details":"We recommend dividing the total frames into 40 frame movies for motion correction. The gain reference image is in the root folder, it does not need to be flipped or rotated.","image_width":"4096","image_height":"4096"}],"workflow_file":null,"grant_references":[{"funding_body":"National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)","code":"R01GM130889","country":"United States"}],"version_history":[],"title":"Cryo-EM micrographs of human DNA polymerase θ helicase domain bound to inhibitor AB25583","principal_investigator":[{"author_orcid":"0000-0002-2274-118X","middle_name":null,"organization":"University of Southern California","street":"1050 Childs Way RRI 103","town_or_city":"Los Angeles","state_or_province":"CA","post_or_zip":"90089","telephone":null,"fax":null,"first_name":"Fumiaki","last_name":"Ito","email":"fumiakii [at] usc.edu","country":"United States","entry":"EMPIAR-11711"}],"status":"REL","deposition_date":"2023-09-18","release_date":"2024-08-29","obsolete_date":null,"update_date":"2024-08-29","corresponding_author":{"author":{"author_orcid":"0000-0002-2274-118X","middle_name":null,"organization":"University of Southern California","street":"1050 Childs Way RRI 103","town_or_city":"Los Angeles","state_or_province":"CA","post_or_zip":"90089","first_name":"Fumiaki","last_name":"Ito","country":"United States"}},"authors":[{"author":{"name":"Ito F","author_orcid":"0000-0002-2274-118X"}},{"author":{"name":"Li Z","author_orcid":null}},{"author":{"name":"Minakhin L","author_orcid":null}},{"author":{"name":"Chandramouly G","author_orcid":null}},{"author":{"name":"Tyagi M","author_orcid":null}},{"author":{"name":"Betsch R","author_orcid":null}},{"author":{"name":"Krais JJ","author_orcid":null}},{"author":{"name":"Tiberi B","author_orcid":null}},{"author":{"name":"Johnson N","author_orcid":null}},{"author":{"name":"Chen XS","author_orcid":null}},{"author":{"name":"Pomerantz RT","author_orcid":null}}],"cross_references":["EMD-44765","EMD-44766"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Ito F","author_orcid":"0000-0002-2274-118X"},{"name":"Li Z","author_orcid":null},{"name":"Minakhin L","author_orcid":null},{"name":"Chandramouly G","author_orcid":null},{"name":"Tyagi M","author_orcid":null},{"name":"Betsch R","author_orcid":null},{"name":"Krais JJ","author_orcid":"0000-0002-3916-3435"},{"name":"Taberi B","author_orcid":null},{"name":"Vekariya U","author_orcid":null},{"name":"Calbert M","author_orcid":"0000-0003-3005-8679"},{"name":"Skorski T","author_orcid":null},{"name":"Johnson N","author_orcid":"0000-0002-0276-0009"},{"name":"Chen XS","author_orcid":"0000-0001-9574-0551"},{"name":"Pomerantz RT","author_orcid":"0000-0003-1194-9871"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM","volume":"15","country":"","first_page":null,"last_page":null,"year":"2024","language":"English","doi":"10.1038/s41467-024-51351-4","pubmedid":"39143110","details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Nature communications","journal_abbreviation":"Nat Commun","issue":"1","preprint":false}],"dataset_size":"4.9 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["9bp9","9bpa"],"entry_doi":"10.6019/EMPIAR-11711"}}