{"EMPIAR-11665":{"imagesets":[{"segmentations":[],"name":"Aligned particles images of the flexible HER2-Trastuzumab-Pertuzumab ternary complex","directory":"data/extract","category":"picked particles - multiframe - processed","header_format":"MRC","data_format":"MRCS","num_images_or_tilt_series":708609,"frames_per_image":1,"frame_range_min":null,"frame_range_max":null,"voxel_type":"32 BIT FLOAT","pixel_width":1.16,"pixel_height":1.16,"micrographs_file_pattern":"","picked_particles_file_pattern":"data/J503_csparc2star-particles.star","picked_particles_directory":"data/extract","details":"This the particle stack for the global reconstruction of the flexible HER2-Trastuzumab-Pertuzumab ternary complex. It allows reconstruction to an overall resolution < 3.3 A. The data sign is +1, white particle on dark background. The accompanying star file is exported from the last round of global refinement in cryoSPARC v. 4.1.2, with all the CTF parameters recorded. The dataset displays considerable continuous conformational variability.","image_width":"280","image_height":"280"}],"workflow_file":null,"grant_references":[],"version_history":[],"title":"Atomic structure and conformational variability of the HER2-trastuzumab-pertuzumab complex","principal_investigator":[{"author_orcid":"0000-0002-0921-6727","middle_name":null,"organization":"CNRS - Institute for Integrative Biology of the Cell (I2BC)","street":"1 avenue de la terrasse","town_or_city":"Gif sur yvette","state_or_province":"Essonne","post_or_zip":"91198","telephone":null,"fax":null,"first_name":"Stephane","last_name":"Bressanelli","email":"stephane.bressanelli [at] i2bc.paris-saclay.fr","country":"France","entry":"EMPIAR-11665"}],"status":"REL","deposition_date":"2023-06-13","release_date":"2024-06-13","obsolete_date":null,"update_date":"2024-06-13","corresponding_author":{"author":{"author_orcid":"0000-0002-9948-680X","middle_name":"Jo","organization":"Sanofi, Integrated Drug Discovery","street":"13, Quai Jules Guesdes - BP 14","town_or_city":"Vitry-sur-seine","state_or_province":"Val-de-Marne","post_or_zip":"94403","first_name":"Remi","last_name":"Ruedas","country":"France"}},"authors":[{"author":{"name":"Ruedas R","author_orcid":"0000-0002-9948-680X"}},{"author":{"name":"Vuillemot R","author_orcid":"0000-0003-3714-9127"}},{"author":{"name":"Tubiana T","author_orcid":"0000-0002-6490-4602"}},{"author":{"name":"Winter JM","author_orcid":null}},{"author":{"name":"Pieri L","author_orcid":"0000-0003-0779-9014"}},{"author":{"name":"Arteni AA","author_orcid":"0000-0001-6462-905X"}},{"author":{"name":"Samson C","author_orcid":null}},{"author":{"name":"Jonic S","author_orcid":"0000-0001-5112-2743"}},{"author":{"name":"Mathieu M","author_orcid":"0000-0003-4960-0632"}},{"author":{"name":"Bressanelli S","author_orcid":"0000-0002-0921-6727"}}],"cross_references":["EMD-17993","EMD-18188","EMD-18189","EMD-18190"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Ruedas R","author_orcid":"0000-0002-9948-680X"},{"name":"Vuillemot R","author_orcid":"0000-0003-3714-9127"},{"name":"Tubiana T","author_orcid":"0000-0002-6490-4602"},{"name":"Winter JM","author_orcid":null},{"name":"Pieri L","author_orcid":"0000-0003-0779-9014"},{"name":"Arteni AA","author_orcid":"0000-0001-6462-905X"},{"name":"Samson C","author_orcid":null},{"name":"Jonic S","author_orcid":"0000-0001-5112-2743"},{"name":"Mathieu M","author_orcid":"0000-0003-4960-0632"},{"name":"Bressanelli S","author_orcid":"0000-0002-0921-6727"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex","volume":"216","country":"","first_page":null,"last_page":null,"year":"2024","language":"English","doi":"10.1016/j.jsb.2024.108095","pubmedid":"38723875","details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Journal of structural biology","journal_abbreviation":"J Struct Biol","issue":"2","preprint":false}],"dataset_size":"207.2 GB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["8pwh","8q6j"],"entry_doi":"10.6019/EMPIAR-11665"}}