{"EMPIAR-11531":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame micrographs of wild-type mouse mitochondrial complex I from an as-prepared inhibited by piericidin A","directory":"data","category":"micrographs - multiframe","header_format":"MRC","data_format":"MRC","num_images_or_tilt_series":1565,"frames_per_image":40,"frame_range_min":1,"frame_range_max":40,"voxel_type":"SIGNED 16 BIT INTEGER","pixel_width":1.06,"pixel_height":1.06,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"Gain-corrected micrographs were imaged using a Falcon III detector in counting mode on an FEI 300 keV Titan Krios microscope with a 100 μm objective aperture. The sample was frozen on PEGylated gold grids.","image_width":"4096","image_height":"4096"}],"workflow_file":null,"grant_references":[{"funding_body":"Medical Research Council (MRC, United Kingdom)","code":"MC_UU_00015/2","country":"United Kingdom"},{"funding_body":"Medical Research Council (MRC, United Kingdom)","code":"MC_UU_00028/1","country":"United Kingdom"}],"version_history":[],"title":"Single particle cryo-EM dataset of Mus musculus mitochondrial complex I bound with inhibitor Piericidin A","principal_investigator":[{"author_orcid":"0000-0001-8667-6797","middle_name":null,"organization":"MRC mitochondrial Biology Unit, University of Cambridge","street":"The Keith Peters Building, Cambridge Biomedical Campus, Hills Road","town_or_city":"Cambridge","state_or_province":"Cambridgeshire","post_or_zip":"CB2 0XY","telephone":null,"fax":null,"first_name":"Judy","last_name":"Hirst","email":"jh [at] mrc-mbu.cam.ac.uk","country":"United Kingdom","entry":"EMPIAR-11531"}],"status":"REL","deposition_date":"2023-04-24","release_date":"2023-08-11","obsolete_date":null,"update_date":"2023-08-11","corresponding_author":{"author":{"author_orcid":"0000-0001-8667-6797","middle_name":null,"organization":"MRC mitochondrial Biology Unit, University of Cambridge","street":"The Keith Peters Building, Cambridge Biomedical Campus, Hills Road","town_or_city":"Cambridge","state_or_province":"Cambridgeshire","post_or_zip":"CB2 0XY","first_name":"Judy","last_name":"Hirst","country":"United Kingdom"}},"authors":[{"author":{"name":"Grba DN","author_orcid":"0000-0003-2915-951X"}},{"author":{"name":"Chung I","author_orcid":"0000-0002-2902-4677"}},{"author":{"name":"Bridges HR","author_orcid":"0000-0001-6890-6050"}},{"author":{"name":"Agip AA","author_orcid":"0000-0002-3020-8262"}},{"author":{"name":"Hirst J","author_orcid":"0000-0001-8667-6797"}}],"cross_references":["EMD-16962"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Grba DN","author_orcid":"0000-0003-2915-951X"},{"name":"Chung I","author_orcid":"0000-0002-2902-4677"},{"name":"Bridges HR","author_orcid":"0000-0001-6890-6050"},{"name":"Agip AA","author_orcid":"0000-0002-3020-8262"},{"name":"Hirst J","author_orcid":"0000-0001-8667-6797"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I","volume":"9","country":"","first_page":null,"last_page":null,"year":"2023","language":"English","doi":"10.1126/sciadv.adi1359","pubmedid":"37531432","details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Science advances","journal_abbreviation":"Sci Adv","issue":"31","preprint":false}],"dataset_size":"1.9 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["8olt"],"entry_doi":"10.6019/EMPIAR-11531"}}