{"EMPIAR-11525":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame micrographs of ex vivo murine AApoAII fibrils","directory":"data/data","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":3083,"frames_per_image":40,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED 16 BIT INTEGER","pixel_width":null,"pixel_height":null,"micrographs_file_pattern":"data/data/*.tif","picked_particles_file_pattern":"data/ManualPick/Morphology_*/part_*/*_manualpick.star","picked_particles_directory":"data/ManualPick","details":"Krios1 Quantum-K2\nCs 2.7\n300kV EFTEM nanpprobe\nx130k spot 8 beam size 620nm\nc2=50  objective_aperture=100\n\nGIF-K2 counting\n12s exposure 40 frames\ntotal dose at the sample 42.70e/A2\n1 pixel = 1.04A\ndose rate ~3 e/pix/s\n\ndefocus range -1.2 to -2.5\n\nGain reference is already applied to the micrographs and the NOTE.txt contains the EM information.\nThumbnails and power spectra (/data/thumbs) are provided, as well as the defect files (/data/data).\nThe ManualPick folder contains the coordinates for two different fibril morphologies. Coordinates files are divided in part_1 and part_2 for each morphologies and they are connected to micrographs with different defect files.","image_width":"3838","image_height":"3710"}],"workflow_file":null,"grant_references":[{"funding_body":"German Research Foundation (DFG)","code":"FA 456/27-1","country":"Germany"},{"funding_body":"German Research Foundation (DFG)","code":"FA 456/28-1","country":"Germany"}],"version_history":[],"title":"Ex vivo murine AApoAII amyloid fibril","principal_investigator":[{"author_orcid":"0000-0003-2123-6816","middle_name":null,"organization":"Institut für Proteinbiochemie, Universität Ulm","street":"8/1 Helmholtzstrasse","town_or_city":"Ulm","state_or_province":"Baden Württemberg","post_or_zip":"89081","telephone":null,"fax":null,"first_name":"Marcus","last_name":"Fändrich","email":"marcus.faendrich [at] uni-ulm.de","country":"Germany","entry":"EMPIAR-11525"}],"status":"REL","deposition_date":"2023-03-31","release_date":"2024-03-18","obsolete_date":null,"update_date":"2024-03-18","corresponding_author":{"author":{"author_orcid":"0000-0002-9442-460X","middle_name":null,"organization":"Institut für Proteinbiochemie, Universität Ulm","street":"8/1 Helmholtzstrasse","town_or_city":"Ulm","state_or_province":"Baden Württemberg","post_or_zip":"89081","first_name":"Matthias","last_name":"Schmidt","country":"Germany"}},"authors":[{"author":{"name":"Andreotti S","author_orcid":"0000-0003-1705-1034"}},{"author":{"name":"Schmidt M","author_orcid":"0000-0002-9442-460X"}},{"author":{"name":"Fändrich M","author_orcid":"0000-0003-2123-6816"}}],"cross_references":["EMD-17105","EMD-17104"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Andreotti G","author_orcid":"0000-0001-8156-1050"},{"name":"Baur J","author_orcid":"0000-0001-9339-2434"},{"name":"Ugrina M","author_orcid":null},{"name":"Pfeiffer PB","author_orcid":null},{"name":"Hartmann M","author_orcid":null},{"name":"Wiese S","author_orcid":null},{"name":"Miyahara H","author_orcid":null},{"name":"Higuchi K","author_orcid":null},{"name":"Schwierz N","author_orcid":null},{"name":"Schmidt M","author_orcid":"0000-0002-9442-460X"},{"name":"Fändrich M","author_orcid":"0000-0003-2123-6816"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Insights into the Structural Basis of Amyloid Resistance Provided by Cryo-EM Structures of AApoAII Amyloid Fibrils","volume":"436","country":"Germany","first_page":null,"last_page":null,"year":"2024","language":"English","doi":"10.1016/j.jmb.2024.168441","pubmedid":"38199491","details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Journal of molecular biology","journal_abbreviation":"J Mol Biol","issue":"4","preprint":false}],"dataset_size":"510.6 GB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["8oq5","8oq4"],"entry_doi":"10.6019/EMPIAR-11525"}}