{"EMPIAR-11470":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame micrographs of HCN4 channel bound to Ivabradine","directory":"data","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":31670,"frames_per_image":40,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":0.42,"pixel_height":0.42,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"The micrographs comes from two different data collection sessions and they are divided in two separated folders, each containing their own gain-reference file. The micrographs were recorded in super-resolution mode.","image_width":"11520","image_height":"8184"}],"workflow_file":null,"grant_references":[{"funding_body":"Leducq Foundation","code":"TNE19CVD03","country":"France"},{"funding_body":"Fondazione CARIPLO","code":"2018-0231","country":"Italy"},{"funding_body":"European Research Council (ERC)","code":"ERC Advanced grant noMAGIC 695078","country":"Italy"},{"funding_body":"National Institutes of Health (NIH)","code":"NIH grants R01-NS109366","country":"United States"},{"funding_body":"National Institutes of Health (NIH)","code":"P41-GM116799","country":"United States"},{"funding_body":"National Institutes of Health (NIH)","code":"R01-GM107462","country":"United States"}],"version_history":[],"title":"Unaligned cryo-EM micrographs of HCN4 channel bound to Ivabradine","principal_investigator":[{"author_orcid":"0000-0002-1860-406X","middle_name":null,"organization":"Department of Biosciences, University of Milan","street":null,"town_or_city":"Milan","state_or_province":null,"post_or_zip":"20133","telephone":null,"fax":null,"first_name":"Anna","last_name":"Moroni","email":"anna.moroni [at] unimi.it","country":"Italy","entry":"EMPIAR-11470"},{"author_orcid":"0000-0001-5035-5174","middle_name":null,"organization":"Department of Biosciences, University of Milan","street":null,"town_or_city":"Milan","state_or_province":null,"post_or_zip":"20133","telephone":null,"fax":null,"first_name":"Andrea","last_name":"Saponaro","email":"antonio.chaves [at] unimi.it","country":"Italy","entry":"EMPIAR-11470"}],"status":"REL","deposition_date":"2023-03-16","release_date":"2025-03-21","obsolete_date":null,"update_date":"2025-03-21","corresponding_author":{"author":{"author_orcid":"0000-0003-3287-9024","middle_name":null,"organization":"Department of Biosciences, University of Milan","street":null,"town_or_city":"Milan","state_or_province":null,"post_or_zip":"20133","first_name":"Antonio","last_name":"Chaves-Sanjuan","country":"Italy"}},"authors":[{"author":{"name":"Saponaro A","author_orcid":"0000-0001-5035-5174"}},{"author":{"name":"Chaves-Sanjuan A","author_orcid":"0000-0003-3287-9024"}},{"author":{"name":"Sharifzadeh AS","author_orcid":null}},{"author":{"name":"Clarke OB","author_orcid":"0000-0003-1876-196X"}},{"author":{"name":"Marabelli C","author_orcid":"0000-0002-6613-4306"}},{"author":{"name":"Bolognesi M","author_orcid":"0000-0002-9253-5170"}},{"author":{"name":"Thiel G","author_orcid":"0000-0002-2335-1351"}},{"author":{"name":"Moroni A","author_orcid":"0000-0002-1860-406X"}}],"cross_references":["EMD-16860"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Saponaro A","author_orcid":"0000-0001-5035-5174"},{"name":"Krumbach JH","author_orcid":null},{"name":"Chaves-Sanjuan A","author_orcid":"0000-0003-3287-9024"},{"name":"Sharifzadeh AS","author_orcid":"0000-0002-2922-8944"},{"name":"Porro A","author_orcid":"0000-0003-4845-6165"},{"name":"Castelli R","author_orcid":"0009-0000-6773-7486"},{"name":"Hamacher K","author_orcid":null},{"name":"Bolognesi M","author_orcid":"0000-0002-9253-5170"},{"name":"DiFrancesco D","author_orcid":"0000-0002-7322-1790"},{"name":"Clarke OB","author_orcid":"0000-0003-1876-196X"},{"name":"Thiel G","author_orcid":"0000-0002-2335-1351"},{"name":"Moroni A","author_orcid":"0000-0002-1860-406X"}],"editors":[{"name":"Chaves-Sanjuan A","author_orcid":"0000-0003-3287-9024"}],"published":true,"j_or_nj_citation":true,"title":"Structural determinants of ivabradine block of the open pore of HCN4","volume":"121","country":"","first_page":null,"last_page":null,"year":"2024","language":"English","doi":"10.1073/pnas.2402259121","pubmedid":"38917012","details":"The micrographs are unaligned 40-frames movies with a total dose of 40e/A2. collected in super-resolution mode. Gain reference files are in the folder containing the micrographs.","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Proceedings of the National Academy of Sciences of the United States of America","journal_abbreviation":"Proc Natl Acad Sci U S A","issue":"27","preprint":false}],"dataset_size":"9.3 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["8ofi"],"entry_doi":"10.6019/EMPIAR-11470"}}