{"EMPIAR-11297":{"imagesets":[{"segmentations":[],"name":"Cryo-EM movies of the human α1β3γ2 GABAA receptor in a lipid bilayer bound to bicuculline","directory":"data","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":988,"frames_per_image":75,"frame_range_min":1,"frame_range_max":75,"voxel_type":"SIGNED 16 BIT INTEGER","pixel_width":1.07,"pixel_height":1.07,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"","image_width":"4096","image_height":"4096"}],"workflow_file":null,"grant_references":[],"version_history":[],"title":"Cryo-EM movies of the human α1β3γ2 GABA<sub>A</sub> receptor in a lipid bilayer bound to bicuculline","principal_investigator":[{"author_orcid":"0000-0003-3783-1388","middle_name":"Radu","organization":"MRC Laboratory of Molecular Biology","street":"Francis Crick Avenue","town_or_city":"Cambridge","state_or_province":"Cambridgeshire","post_or_zip":"CB2 0QH","telephone":"+44-1223-267049","fax":"+44-1223-268305","first_name":"Alexandru","last_name":"Aricescu","email":"radu [at] mrc-lmb.cam.ac.uk","country":"United Kingdom","entry":"EMPIAR-11297"}],"status":"REL","deposition_date":"2022-06-30","release_date":"2022-11-15","obsolete_date":null,"update_date":"2023-02-08","corresponding_author":{"author":{"author_orcid":"0000-0003-3783-1388","middle_name":"Radu","organization":"MRC Laboratory of Molecular Biology","street":"Francis Crick Avenue","town_or_city":"Cambridge","state_or_province":"Cambridgeshire","post_or_zip":"CB2 0QH","first_name":"Alexandru","last_name":"Aricescu","country":"United Kingdom"}},"authors":[{"author":{"name":"Masiulis S","author_orcid":"0000-0001-8986-913X"}},{"author":{"name":"Desai R","author_orcid":"0000-0003-1270-7188"}},{"author":{"name":"Uchanski T","author_orcid":"0000-0001-8456-4206"}},{"author":{"name":"Serna Martin I","author_orcid":"0000-0003-0305-0057"}},{"author":{"name":"Laverty D","author_orcid":null}},{"author":{"name":"Karia D","author_orcid":"0000-0002-3776-1650"}},{"author":{"name":"Malinauskas T","author_orcid":"0000-0002-4847-5529"}},{"author":{"name":"Zivanov J","author_orcid":"0000-0001-8407-0759"}},{"author":{"name":"Pardon E","author_orcid":"0000-0002-2466-0172"}},{"author":{"name":"Kotecha A","author_orcid":"0000-0002-4480-5439"}},{"author":{"name":"Steyaert J","author_orcid":"0000-0002-3825-874X"}},{"author":{"name":"Miller KW","author_orcid":null}},{"author":{"name":"Aricescu AR","author_orcid":"0000-0003-3783-1388"}}],"cross_references":["EMD-0280"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Masiulis S","author_orcid":"0000-0001-8986-913X"},{"name":"Desai R","author_orcid":"0000-0003-1270-7188"},{"name":"Uchański T","author_orcid":"0000-0001-8456-4206"},{"name":"Serna Martin I","author_orcid":"0000-0003-0305-0057"},{"name":"Laverty D","author_orcid":null},{"name":"Karia D","author_orcid":"0000-0002-3776-1650"},{"name":"Malinauskas T","author_orcid":"0000-0002-4847-5529"},{"name":"Zivanov J","author_orcid":"0000-0001-8407-0759"},{"name":"Pardon E","author_orcid":"0000-0002-2466-0172"},{"name":"Kotecha A","author_orcid":"0000-0002-4480-5439"},{"name":"Steyaert J","author_orcid":"0000-0002-3825-874X"},{"name":"Miller KW","author_orcid":null},{"name":"Aricescu AR","author_orcid":"0000-0003-3783-1388"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"GABA<sub>A</sub> receptor signalling mechanisms revealed by structural pharmacology","volume":"565","country":"","first_page":"454","last_page":"459","year":"2019","language":"English","doi":"10.1038/s41586-018-0832-5","pubmedid":"30602790","details":"Raw movies from Falcon 3 detector in electron-counting mode at a nominal magnification of 75,000, corresponding to a calibrated pixel size of 1.07 Å. Each micrograph was collected as a 60-s exposure, comprising 75 movie frames at a dose rate of 0.55 electrons per pixel per second for a total accumulated dose of 30 e/A2 with a Volta Phase Plate.","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Nature","journal_abbreviation":"Nature","issue":"7740","preprint":false}],"dataset_size":"1.2 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["6huk"],"entry_doi":"10.6019/EMPIAR-11297"}}