{"EMPIAR-11140":{"imagesets":[{"segmentations":[],"name":"Cryo-EM reconstruction of alpha-synuclein filaments from Parkinson's disease dementia","directory":"data/Micrographs","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":10874,"frames_per_image":42,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":0.727,"pixel_height":0.727,"micrographs_file_pattern":"data/Micrographs/Dataset*","picked_particles_file_pattern":"data/picking/Dataset*","picked_particles_directory":"data","details":"The files were written as eer files by EPU and then converted to TIFF files by relion_convert_to_tiff. During this process, the pixel size in the header was lost. The real pixel size is 0.727 A/px. The dose rate is 1 e/A2/frame for Dataset1 and Dataset2. Please use gain-reference accordingly without any rotation or flipping.\npicking contains start-end coordinates of the manually picked filaments of Dataset1 and Dataset2, respectively.\nRefine070_run_data.star contains STAR file(s) with the metadata of the final refined segments.","image_width":"4096","image_height":"4096"}],"workflow_file":null,"grant_references":[],"version_history":[],"title":"Single particle cryo-EM dataset of sarkosyl-insoluble fraction from the cingulate cortex of an individual with Parkinson's disease dementia -synuclein filaments","principal_investigator":[{"author_orcid":"0000-0002-0462-6540","middle_name":"HW","organization":"MRC Laboratory of Molecular Biology","street":"Francis Crick Avenue","town_or_city":"Cambridge","state_or_province":"Cambridgeshire","post_or_zip":"CB2 0QH","telephone":null,"fax":null,"first_name":"Sjors","last_name":"Scheres","email":"scheres [at] mrc-lmb.cam.ac.uk","country":"United Kingdom","entry":"EMPIAR-11140"},{"author_orcid":"0000-0002-5214-7886","middle_name":null,"organization":"MRC Laboratory of Molecular Biology","street":"Francis Crick Avenue","town_or_city":"Cambridge","state_or_province":"Cambridgeshire","post_or_zip":"CB2 0QH","telephone":null,"fax":null,"first_name":"Michel","last_name":"Goedert","email":"mg [at] mrc-lmb.cam.ac.uk","country":"United Kingdom","entry":"EMPIAR-11140"}],"status":"REL","deposition_date":"2022-06-28","release_date":"2022-11-11","obsolete_date":null,"update_date":"2022-11-11","corresponding_author":{"author":{"author_orcid":"0000-0003-2238-6437","middle_name":null,"organization":"MRC-LMB","street":"Francis Crick Avenue, Cambridge Biomedical Campus","town_or_city":"Cambridge","state_or_province":"Cambridgeshire","post_or_zip":"CB2 0QH","first_name":"Yang","last_name":"Yang","country":"United Kingdom"}},"authors":[{"author":{"name":"Yang Y","author_orcid":"0000-0003-2238-6437"}},{"author":{"name":"Shi Y","author_orcid":"0000-0003-1579-7561"}},{"author":{"name":"Schweighauser M","author_orcid":"0000-0002-1848-1610"}},{"author":{"name":"Zhang X","author_orcid":null}},{"author":{"name":"Kotecha A","author_orcid":"0000-0002-4480-5439"}},{"author":{"name":"Murzin AG","author_orcid":null}},{"author":{"name":"Garringer HJ","author_orcid":"0000-0002-1899-7676"}},{"author":{"name":"Cullinane PW","author_orcid":null}},{"author":{"name":"Saito Y","author_orcid":null}},{"author":{"name":"Foroud T","author_orcid":"0000-0002-5549-2212"}},{"author":{"name":"Warner TT","author_orcid":"0000-0001-6195-6995"}},{"author":{"name":"Hasegawa K","author_orcid":null}},{"author":{"name":"Vidal R","author_orcid":null}},{"author":{"name":"Murayama S","author_orcid":null}},{"author":{"name":"Revesz T","author_orcid":null}},{"author":{"name":"Ghetti B","author_orcid":"0000-0002-1842-8019"}},{"author":{"name":"Hasegawa M","author_orcid":"0000-0001-7415-8159"}},{"author":{"name":"Lashley T","author_orcid":"0000-0001-7389-0348"}},{"author":{"name":"Scheres SHW","author_orcid":"0000-0002-0462-6540"}},{"author":{"name":"Goedert M","author_orcid":"0000-0002-5214-7886"}}],"cross_references":["EMD-15285"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Yang Y","author_orcid":"0000-0003-2238-6437"},{"name":"Shi Y","author_orcid":"0000-0003-1579-7561"},{"name":"Schweighauser M","author_orcid":"0000-0002-1848-1610"},{"name":"Zhang X","author_orcid":null},{"name":"Kotecha A","author_orcid":"0000-0002-4480-5439"},{"name":"Murzin AG","author_orcid":null},{"name":"Garringer HJ","author_orcid":"0000-0002-1899-7676"},{"name":"Cullinane PW","author_orcid":null},{"name":"Saito Y","author_orcid":null},{"name":"Foroud T","author_orcid":"0000-0002-5549-2212"},{"name":"Warner TT","author_orcid":"0000-0001-6195-6995"},{"name":"Hasegawa K","author_orcid":null},{"name":"Vidal R","author_orcid":null},{"name":"Murayama S","author_orcid":null},{"name":"Revesz T","author_orcid":null},{"name":"Ghetti B","author_orcid":"0000-0002-1842-8019"},{"name":"Hasegawa M","author_orcid":"0000-0001-7415-8159"},{"name":"Lashley T","author_orcid":"0000-0001-7389-0348"},{"name":"Scheres SHW","author_orcid":"0000-0002-0462-6540"},{"name":"Goedert M","author_orcid":"0000-0002-5214-7886"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Structures of α-synuclein filaments from human brains with Lewy pathology","volume":"610","country":"","first_page":"791","last_page":"795","year":"2022","language":"English","doi":"10.1038/s41586-022-05319-3","pubmedid":"36108674","details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Nature","journal_abbreviation":"Nature","issue":"7933","preprint":false},{"authors":[{"name":"Yang Y","author_orcid":"0000-0003-2238-6437"},{"name":"Shi Y","author_orcid":null},{"name":"Schweighauser M","author_orcid":null},{"name":"Zhang X","author_orcid":null},{"name":"Kotecha A","author_orcid":null},{"name":"Murzin AG","author_orcid":null},{"name":"Garringer HJ","author_orcid":null},{"name":"Cullinane PW","author_orcid":null},{"name":"Saito Y","author_orcid":null},{"name":"Foroud T","author_orcid":null},{"name":"Warner TT","author_orcid":null},{"name":"Hasegawa K","author_orcid":null},{"name":"Vidal R","author_orcid":null},{"name":"Murayama S","author_orcid":null},{"name":"Revesz T","author_orcid":null},{"name":"Ghetti B","author_orcid":"0000-0002-1842-8019"},{"name":"Hasegawa M","author_orcid":null},{"name":"Lashley T","author_orcid":null},{"name":"Scheres SHW","author_orcid":"0000-0002-0462-6540"},{"name":"Goedert M","author_orcid":"0000-0002-5214-7886"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Cryo-EM structures of α-synuclein filaments from Parkinson’s disease and dementia with Lewy bodies","volume":null,"country":"","first_page":null,"last_page":null,"year":"2022","language":null,"doi":"10.1101/2022.07.12.499706","pubmedid":null,"details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"bioRxiv","journal_abbreviation":"","issue":null,"preprint":true}],"dataset_size":"1.2 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["8a9l"],"entry_doi":"10.6019/EMPIAR-11140"}}