{"EMPIAR-10991":{"imagesets":[{"segmentations":[],"name":"Single particle cryo-EM dataset of mitochondrial respiratory complex I from Bos taurus in DDM in the presence of IM1761092","directory":"data","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":17203,"frames_per_image":40,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":0.536,"pixel_height":0.536,"micrographs_file_pattern":"data","picked_particles_file_pattern":"","picked_particles_directory":"","details":"Non-gain corrected micrographs were imaged using a Gatan K3  in super-resolution mode and with a GIF BioQuantum energy filter (20 eV slit width) on an FEI 300 keV Titan Krios microscope with a 100 μm objective aperture. 1.7s exposures captured in 40 frames and a total dose of 40 electrons Å-2. Dataset also contains xml files for each image, and gain reference files.","image_width":"11520","image_height":"8184"}],"workflow_file":null,"grant_references":[],"version_history":[],"title":"Single particle cryo-EM dataset of mitochondrial respiratory complex I from Bos taurus in DDM in the presence of IM1761092","principal_investigator":[{"author_orcid":"0000-0001-8667-6797","middle_name":null,"organization":"MRC Mitochondrial Biology Unit, University of Cambridge","street":"Hills road","town_or_city":"Cambridge","state_or_province":"Cambridgeshire","post_or_zip":"Cb2 0xy","telephone":null,"fax":null,"first_name":"Hirst","last_name":"Judy","email":"jh [at] mrc-mbu.cam.ac.uk","country":"United Kingdom","entry":"EMPIAR-10991"}],"status":"REL","deposition_date":"2022-03-22","release_date":"2023-02-28","obsolete_date":null,"update_date":"2023-03-01","corresponding_author":{"author":{"author_orcid":"0000-0001-6890-6050","middle_name":"Ruth","organization":"MRC Mitochondrial Biology Unit, University of Cambridge","street":"Hills road","town_or_city":"Cambridge","state_or_province":"Cambridgeshire","post_or_zip":"Cb2 0xy","first_name":"Hannah","last_name":"Bridges","country":"United Kingdom"}},"authors":[{"author":{"name":"Bridges HR","author_orcid":"0000-0001-6890-6050"}},{"author":{"name":"Blaza JN","author_orcid":"0000-0001-5420-2116"}},{"author":{"name":"Yin Z","author_orcid":"0000-0002-3846-0147"}},{"author":{"name":"Chung I","author_orcid":"0000-0002-2902-4677"}},{"author":{"name":"Pollak MN","author_orcid":"0000-0003-3047-0604"}},{"author":{"name":"Hirst J","author_orcid":"0000-0001-8667-6797"}}],"cross_references":["EMD-14275","EMD-14308","EMD-14298","EMD-14285","EMD-14310","EMD-14300","EMD-14264","EMD-14289","EMD-14251","EMD-14255"],"biostudies_references":[],"idr_references":[],"empiar_references":[{"name":"EMPIAR-10984"}],"citation":[{"authors":[{"name":"Bridges HR","author_orcid":"0000-0001-6890-6050"},{"name":"Blaza JN","author_orcid":"0000-0001-5420-2116"},{"name":"Yin Z","author_orcid":"0000-0002-3846-0147"},{"name":"Chung I","author_orcid":"0000-0002-2902-4677"},{"name":"Pollak MN","author_orcid":"0000-0003-3047-0604"},{"name":"Hirst J","author_orcid":"0000-0001-8667-6797"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides","volume":"379","country":"","first_page":"351","last_page":"357","year":"2023","language":"English","doi":"10.1126/science.ade3332","pubmedid":"36701435","details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Science (New York, N.Y.)","journal_abbreviation":"Science","issue":"6630","preprint":false},{"authors":[{"name":"Bridges HR","author_orcid":"0000-0001-6890-6050"},{"name":"Blaza JN","author_orcid":"0000-0001-5420-2116"},{"name":"Yin Z","author_orcid":"0000-0002-3846-0147"},{"name":"Chung I","author_orcid":"0000-0002-2902-4677"},{"name":"Pollak MN","author_orcid":"0000-0003-3047-0604"},{"name":"Hirst J","author_orcid":"0000-0001-8667-6797"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Structural Basis of Mammalian Respiratory Complex I Inhibition by Medicinal Biguanides","volume":null,"country":"","first_page":null,"last_page":null,"year":"2022","language":null,"doi":"10.1101/2022.08.09.503333","pubmedid":null,"details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"bioRxiv","journal_abbreviation":"","issue":null,"preprint":true}],"dataset_size":"6.5 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["7r41"],"entry_doi":"10.6019/EMPIAR-10991"}}