{"EMPIAR-10927":{"imagesets":[{"segmentations":[],"name":"Single-particle cryo-EM dataset of Mus musculus mitochondrial complex I co-purified with the inhibitor acetogenin","directory":"data","category":"micrographs - multiframe","header_format":"MRC","data_format":"MRC","num_images_or_tilt_series":1283,"frames_per_image":50,"frame_range_min":null,"frame_range_max":null,"voxel_type":"32 BIT FLOAT","pixel_width":1.043,"pixel_height":1.043,"micrographs_file_pattern":"data/FoilHole_*.mrc","picked_particles_file_pattern":"","picked_particles_directory":"","details":"Raw, multi-frame micrographs (MRC files) are deposited. Micrographs were imaged using a Gatan K2 summit camera in counting mode and GIF Quantum energy filter (20 eV slit width) on an FEI 300 keV Titan Krios microscope with a 100 μm objective aperture. 10s exposures captured in 50 frames and a total dose of 50 electrons Å-2. A pixel size of 1.043 Å was used.","image_width":"3838","image_height":"3710"}],"workflow_file":null,"grant_references":[],"version_history":[],"title":"Single particle cryo-EM dataset of Mus musculus mitochondrial complex I bound with an acetogenin inhibitor","principal_investigator":[{"author_orcid":"0000-0001-8667-6797","middle_name":null,"organization":"MRC Mitochondrial Biology Unit","street":"Hills Road","town_or_city":"Cambridge","state_or_province":"Cambridgeshire","post_or_zip":"CB2 0XY","telephone":null,"fax":null,"first_name":"Judy","last_name":"Hirst","email":"jh [at] mrc-mbu.cam.ac.uk","country":"United Kingdom","entry":"EMPIAR-10927"}],"status":"REL","deposition_date":"2021-12-07","release_date":"2022-04-25","obsolete_date":null,"update_date":"2022-04-25","corresponding_author":{"author":{"author_orcid":"0000-0001-8667-6797","middle_name":null,"organization":"MRC Mitochondrial Biology Unit","street":"Hills Road","town_or_city":"Cambridge","state_or_province":"Cambridgeshire","post_or_zip":"CB2 0XY","first_name":"Judy","last_name":"Hirst","country":"United Kingdom"}},"authors":[{"author":{"name":"Grba DN","author_orcid":"0000-0003-2915-951X"}},{"author":{"name":"Blaza JN","author_orcid":"0000-0001-5420-2116"}},{"author":{"name":"Bridges HR","author_orcid":"0000-0001-6890-6050"}},{"author":{"name":"Agip AA","author_orcid":null}},{"author":{"name":"Yin Z","author_orcid":"0000-0002-3846-0147"}},{"author":{"name":"Murai M","author_orcid":"0000-0001-6601-2854"}},{"author":{"name":"Miyoshi H","author_orcid":"0000-0002-1792-554X"}},{"author":{"name":"Hirst J","author_orcid":"0000-0001-8667-6797"}}],"cross_references":["EMD-13611"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Grba DN","author_orcid":"0000-0003-2915-951X"},{"name":"Blaza JN","author_orcid":"0000-0001-5420-2116"},{"name":"Bridges HR","author_orcid":"0000-0001-6890-6050"},{"name":"Agip AA","author_orcid":null},{"name":"Yin Z","author_orcid":"0000-0002-3846-0147"},{"name":"Murai M","author_orcid":"0000-0001-6601-2854"},{"name":"Miyoshi H","author_orcid":"0000-0002-1792-554X"},{"name":"Hirst J","author_orcid":"0000-0001-8667-6797"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I","volume":"298","country":"","first_page":null,"last_page":null,"year":"2022","language":"English","doi":"10.1016/j.jbc.2022.101602","pubmedid":"35063503","details":"Raw, multi-frame micrographs (MRC files) are deposited. Micrographs were imaged using a Gatan K2 summit camera in counting mode and GIF Quantum energy filter (20 eV slit width) on an FEI 300 keV Titan Krios microscope with a 100 μm objective aperture. 10s exposures captured in 50 frames and a total dose of 50 electrons Å-2. A pixel size of 1.043 Å was used.","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"The Journal of biological chemistry","journal_abbreviation":"J Biol Chem","issue":"3","preprint":false}],"dataset_size":"3.3 TB","experiment_type":"EMDB","scale":null,"related_pdb_entries":["7psa"],"entry_doi":"10.6019/EMPIAR-10927"}}