{"EMPIAR-10925":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame micrographs of microtubule bound C-terminus of LRRK2 (I2020T) with MLi-2 kinase inhibitor present","directory":"data","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":2354,"frames_per_image":55,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED 16 BIT INTEGER","pixel_width":1.16,"pixel_height":1.16,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"Contains data collected from 2 grids (20sep10b and 20sep30c) made on the same day with same conditions. Each folder contains its own gain reference with the \"_norm.mrc\" suffix found in the references folder. Blank dark references are also included but are not needed for correction. Gain correction in cryosparc should work with default settings, while for motioncor2, please flip the image and apply no rotation.","image_width":"3710","image_height":"3838"}],"workflow_file":null,"grant_references":[],"version_history":[],"title":"C-terminal half of LRRK2 (I2020T) bound to microtubule in presence of MLi-2 kinase inhibitor","principal_investigator":[{"author_orcid":"0000-0002-7732-7023","middle_name":null,"organization":"CMM, UCSD","street":"9500 Gilman Dr, MC 0694","town_or_city":"La Jolla","state_or_province":"California","post_or_zip":"92093","telephone":null,"fax":null,"first_name":"Andres","last_name":"Leschziner","email":"aleschziner [at] ucsd.edu","country":"United States","entry":"EMPIAR-10925"}],"status":"REL","deposition_date":"2021-09-21","release_date":"2023-01-03","obsolete_date":null,"update_date":"2023-01-12","corresponding_author":{"author":{"author_orcid":"0000-0003-1033-9270","middle_name":null,"organization":"CMM, UCSD","street":"9500 Gilman Dr, MC 0694","town_or_city":"La Jolla","state_or_province":"California","post_or_zip":"92093","first_name":"Mariusz","last_name":"Matyszewski","country":"United States"}},"authors":[{"author":{"name":"Matyszewski M","author_orcid":"0000-0003-1033-9270"}},{"author":{"name":"Leschziner AE","author_orcid":"0000-0002-7732-7023"}}],"cross_references":["EMD-25906","EMD-25897","EMD-25658","EMD-25908","EMD-25907","EMD-25649","EMD-25664"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Snead DM","author_orcid":"0000-0001-7839-452X"},{"name":"Matyszewski M","author_orcid":"0000-0003-1033-9270"},{"name":"Dickey AM","author_orcid":"0000-0001-8725-0982"},{"name":"Lin YX","author_orcid":"0000-0002-1016-4776"},{"name":"Leschziner AE","author_orcid":"0000-0002-7732-7023"},{"name":"Reck-Peterson SL","author_orcid":"0000-0002-1553-465X"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules","volume":"29","country":"","first_page":"1196","last_page":"1207","year":"2022","language":"English","doi":"10.1038/s41594-022-00863-y","pubmedid":"36510024","details":"Publication includes structures of the C-terminal half of LRRK2 (I2020T) bound to microtubules as filaments, as well a structure of the C-terminal half of LRRK1.","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Nature structural & molecular biology","journal_abbreviation":"Nat Struct Mol Biol","issue":"12","preprint":false}],"dataset_size":"684.8 GB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["7thy","7thz"],"entry_doi":"10.6019/EMPIAR-10925"}}