{"EMPIAR-10387":{"imagesets":[{"segmentations":[],"name":"Aligned, summed and exposure weighted micrographs of HIV-1 intasome bound to compound 4d.","directory":"data/Sums","category":"micrographs - single frame","header_format":"MRC","data_format":"MRC","num_images_or_tilt_series":2022,"frames_per_image":77,"frame_range_min":null,"frame_range_max":null,"voxel_type":"32 BIT FLOAT","pixel_width":0.79,"pixel_height":0.79,"micrographs_file_pattern":"data/Sums/*DW.mrc","picked_particles_file_pattern":"data/Particle-Stack/18jul30a_4d_F3-77_vol180-1_2-88A.mrc","picked_particles_directory":"data/Particle-Stack","details":"Aligned, summed and exposure weighted micrographs of HIV-1 intasome bound to compound 4d. Micrographs were aligned and summed using MotionCor2, with 5 by 5 patch and exposure weighting. The first 3 frames, which had the most beam-induced movement, were discarded.\n\nRegarding particle stack of HIV-1 intasome bound to compound 4d. Particles were extracted from aligned, exposured weighted and summed micrographs. This stack contains 138,770 particles (384 x 384 pixels) and was processed in cisTEM. Both *mrc and *par files are included.","image_width":"3710","image_height":"3838"},{"segmentations":[],"name":"Unaligned raw movies of HIV-1 intasome bound to compound 4d","directory":"data/Rawdata","category":"micrographs - multiframe","header_format":"MRC","data_format":"MRC","num_images_or_tilt_series":2024,"frames_per_image":80,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED 16 BIT INTEGER","pixel_width":0.79,"pixel_height":0.79,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"Unaligned raw multi-frame movies of HIV-1 intasome bound to compound 4d. Movies were collected with a stage tilt angle set to 20, 30, or 40 degrees. The gain normalization reference image (norm) is included for each of the 3 sessions.","image_width":"3710","image_height":"3838"}],"workflow_file":null,"grant_references":[],"version_history":[],"title":"Structural basis for strand-transfer inhibitor binding to HIV intasomes","principal_investigator":[{"author_orcid":"0000-0002-8124-7472","middle_name":null,"organization":"Salk Institute","street":"10010 N Torrey Pines","town_or_city":"San Diego","state_or_province":"California","post_or_zip":"92037","telephone":"8584534100","fax":null,"first_name":"Dmitry","last_name":"Lyumkis","email":"dlyumkis [at] salk.edu","country":"United States","entry":"EMPIAR-10387"}],"status":"REL","deposition_date":"2020-03-26","release_date":"2020-06-30","obsolete_date":null,"update_date":"2020-06-30","corresponding_author":{"author":{"author_orcid":"0000-0003-1333-9102","middle_name":null,"organization":"Salk Institute","street":"10010 N Torrey Pines","town_or_city":"San Diego","state_or_province":"California","post_or_zip":"92037","first_name":"Dario","last_name":"Oliveira Passos","country":"United States"}},"authors":[{"author":{"name":"Passos DO","author_orcid":"0000-0003-1333-9102"}},{"author":{"name":"Li M","author_orcid":null}},{"author":{"name":"Jóźwik IK","author_orcid":"0000-0002-7150-5802"}},{"author":{"name":"Zhao XZ","author_orcid":"0000-0003-1006-6364"}},{"author":{"name":"Santos-Martins D","author_orcid":"0000-0003-4622-3747"}},{"author":{"name":"Yang R","author_orcid":"0000-0001-9640-4189"}},{"author":{"name":"Smith SJ","author_orcid":null}},{"author":{"name":"Jeon Y","author_orcid":"0000-0001-7563-4743"}},{"author":{"name":"Forli S","author_orcid":"0000-0002-5964-7111"}},{"author":{"name":"Hughes SH","author_orcid":null}},{"author":{"name":"Burke TR","author_orcid":"0000-0001-9925-8586"}},{"author":{"name":"Craigie R","author_orcid":"0000-0001-9516-6385"}},{"author":{"name":"Lyumkis D","author_orcid":"0000-0002-8124-7472"}}],"cross_references":["EMD-20484"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Passos DO","author_orcid":"0000-0003-1333-9102"},{"name":"Li M","author_orcid":null},{"name":"Jóźwik IK","author_orcid":"0000-0002-7150-5802"},{"name":"Zhao XZ","author_orcid":"0000-0003-1006-6364"},{"name":"Santos-Martins D","author_orcid":"0000-0003-4622-3747"},{"name":"Yang R","author_orcid":"0000-0001-9640-4189"},{"name":"Smith SJ","author_orcid":null},{"name":"Jeon Y","author_orcid":"0000-0001-7563-4743"},{"name":"Forli S","author_orcid":"0000-0002-5964-7111"},{"name":"Hughes SH","author_orcid":null},{"name":"Burke TR","author_orcid":"0000-0001-9925-8586"},{"name":"Craigie R","author_orcid":"0000-0001-9516-6385"},{"name":"Lyumkis D","author_orcid":"0000-0002-8124-7472"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Structural basis for strand-transfer inhibitor binding to HIV intasomes","volume":"367","country":"United States","first_page":"810","last_page":"814","year":"2020","language":"English","doi":"10.1126/science.aay8015","pubmedid":"32001521","details":"Compressed movies of HIV intasomes bound to the compound 4d. Movies contain 80 raw frames each, accumulating 45 electron per square Angstrom in an 8 second exposure. Pixel size is 0.79.","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Science (New York, N.Y.)","journal_abbreviation":"Science","issue":"6479","preprint":false}],"dataset_size":"4.4 TB","experiment_type":"EMDB","scale":null,"related_pdb_entries":["6puy"],"entry_doi":"10.6019/EMPIAR-10387"}}