{"EMPIAR-10346":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame movies of GLP-1R-TT-OAD2 complex","directory":"data/20181213_PS2.3.3","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":4259,"frames_per_image":67,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":0.413,"pixel_height":0.413,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"- Approximately two-thirds of the data were collected with the Volta phase plate (VPP). \"VPP\" in the filename indicates that the movie was collected with the phase plate.\n- Most movies were collected with a 9-hole beam-image shift acquisition pattern. The filename of such movies contains a four digit number in the range 0000 to 0008 corresponding to the image-shift acquisition position.\n- The image-shift induced beam-tilt was not compensated optically during acquisition. For best results, perform per-image-shift position beam-tilt measurement and correction with CTF refinement. \n- The movies were recorded with Gatan K3 camera in super-resolution mode and saved as gain-normalized LZW compressed TIFF files by SerialEM.\n- Accelerating voltage: 300 kV\n- Spherical aberration: 2.7 mm\n- SuperRes pixel size: 0.413 A/superpixel\n- Physical pixel size: 0.826 A/physpix\n- Exposure rate: 10.9 e/physpix/s\n- Exposure rate: 16.0 e/A^2/s\n- Exposure time: 4.015 s\n- Total exposure: 64.2 e/A^2\n- Number of frames: 67\n- Defocus range: 0.3 - 1.4 um","image_width":"11520","image_height":"8184"},{"segmentations":[],"name":"Unaligned multi-frame movies of GLP-1R-TT-OAD2 complex","directory":"data/PS.TT.3","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":3159,"frames_per_image":62,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":0.826,"pixel_height":0.826,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"- The movies were recorded with Gatan K3 camera in counting (non-superres) mode and saved as gain-normalized LZW compressed TIFF files by SerialEM.\n- All movies were collected with a 9-hole beam-image shift acquisition pattern. The filename contains a four digit number in the range 0000 to 0008 corresponding to the image-shift acquisition position.\n- The image-shift induced beam-tilt was not compensated optically during acquisition. For best results, perform per-image-shift position beam-tilt measurement and correction with CTF refinement. \n- Accelerating voltage: 300 kV\n- Spherical aberration: 2.7 mm\n- Pixel size: 0.826 A/pix\n- Exposure rate: 12.2 e/physpix/s\n- Exposure rate: 17.9 e/A^2/s\n- Exposure time: 3.715 s\n- Total exposure: 66.5 e/A^2\n- Number of frames: 62\n- Defocus range: 0.6 - 1.5 um","image_width":"5760","image_height":"4092"}],"workflow_file":null,"grant_references":[],"version_history":[],"title":"Cryo-EM of GLP-1 receptor bound to TT-OAD2 non-peptidic agonist","principal_investigator":[{"author_orcid":null,"middle_name":null,"organization":"Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University","street":"399 Royal Parade","town_or_city":"Parkville","state_or_province":"Victoria","post_or_zip":"3052","telephone":null,"fax":null,"first_name":"Denise","last_name":"Wootten","email":"denise.wootten [at] monash.edu","country":"Australia","entry":"EMPIAR-10346"}],"status":"REL","deposition_date":"2020-01-09","release_date":"2020-03-10","obsolete_date":null,"update_date":"2020-03-10","corresponding_author":{"author":{"author_orcid":null,"middle_name":null,"organization":"Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University","street":"399 Royal Parade","town_or_city":"Parkville","state_or_province":"Victoria","post_or_zip":"3052","first_name":"Denise","last_name":"Wootten","country":"Australia"}},"authors":[{"author":{"name":"Zhao P","author_orcid":null}},{"author":{"name":"Liang YL","author_orcid":null}},{"author":{"name":"Belousoff MJ","author_orcid":null}},{"author":{"name":"Deganutti G","author_orcid":"0000-0001-8780-2986"}},{"author":{"name":"Fletcher MM","author_orcid":null}},{"author":{"name":"Willard FS","author_orcid":null}},{"author":{"name":"Bell MG","author_orcid":null}},{"author":{"name":"Christe ME","author_orcid":null}},{"author":{"name":"Sloop KW","author_orcid":null}},{"author":{"name":"Inoue A","author_orcid":null}},{"author":{"name":"Truong TT","author_orcid":null}},{"author":{"name":"Clydesdale L","author_orcid":null}},{"author":{"name":"Furness SGB","author_orcid":"0000-0001-8655-8221"}},{"author":{"name":"Christopoulos A","author_orcid":null}},{"author":{"name":"Wang MW","author_orcid":null}},{"author":{"name":"Miller LJ","author_orcid":null}},{"author":{"name":"Reynolds CA","author_orcid":null}},{"author":{"name":"Danev R","author_orcid":null}},{"author":{"name":"Sexton PM","author_orcid":null}},{"author":{"name":"Wootten D","author_orcid":null}}],"cross_references":["EMD-20179"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Zhao P","author_orcid":null},{"name":"Liang YL","author_orcid":null},{"name":"Belousoff MJ","author_orcid":null},{"name":"Deganutti G","author_orcid":"0000-0001-8780-2986"},{"name":"Fletcher MM","author_orcid":null},{"name":"Willard FS","author_orcid":null},{"name":"Bell MG","author_orcid":null},{"name":"Christe ME","author_orcid":null},{"name":"Sloop KW","author_orcid":null},{"name":"Inoue A","author_orcid":null},{"name":"Truong TT","author_orcid":null},{"name":"Clydesdale L","author_orcid":null},{"name":"Furness SGB","author_orcid":"0000-0001-8655-8221"},{"name":"Christopoulos A","author_orcid":null},{"name":"Wang MW","author_orcid":null},{"name":"Miller LJ","author_orcid":null},{"name":"Reynolds CA","author_orcid":null},{"name":"Danev R","author_orcid":null},{"name":"Sexton PM","author_orcid":null},{"name":"Wootten D","author_orcid":null}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Activation of the GLP-1 receptor by a non-peptidic agonist","volume":"577","country":"","first_page":"432","last_page":"436","year":"2020","language":"English","doi":"10.1038/s41586-019-1902-z","pubmedid":"31915381","details":"Original gain-normalized moves in LZW-compressed TIFF format.","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Nature","journal_abbreviation":"Nature","issue":"7790","preprint":false}],"dataset_size":"6.2 TB","experiment_type":"EMDB","scale":null,"related_pdb_entries":["6orv"],"entry_doi":"10.6019/EMPIAR-10346"}}