{"EMPIAR-10340":{"imagesets":[{"segmentations":[],"name":"Unaligned movies for Case 1","directory":"data/Movies/Case1","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":2567,"frames_per_image":40,"frame_range_min":1,"frame_range_max":40,"voxel_type":"32 BIT FLOAT","pixel_width":1.15,"pixel_height":1.15,"micrographs_file_pattern":"data/Micrographs/Case1","picked_particles_file_pattern":"data/Coordinates/Case1","picked_particles_directory":"data/Particles/Case1","details":"Movies/Case1 contains unaligned movies for Case1. The files were written as gain-normalised floating point MRC files by EPU and then converted into gain-unnormalised floating point TIFF files by relion_convert_to_tiff. During this process, the pixel size in the header was lost. The real pixel size is 1.15 A/px. The dose rate is 1.346 e/A2/frame. Please use Movies/Case1/gain-reference.mrc as a gain reference without any rotation or flipping.\n\nMicrographs/Case1 contains aligned and summed micrographs.\n\nCoordinates/Case1 contains manually picked filament coordinates for Type I and Type II filaments before any classifications.\n\nParticles/Case1 contains polished \"shiny\" particles used for final reconstructions.","image_width":"3838","image_height":"3710"},{"segmentations":[],"name":"Unaligned movies for Case 2","directory":"data/Movies/Case2","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":4442,"frames_per_image":50,"frame_range_min":1,"frame_range_max":50,"voxel_type":"SIGNED BYTE","pixel_width":1.15,"pixel_height":1.15,"micrographs_file_pattern":"data/Micrographs/Case2","picked_particles_file_pattern":"data/Coordinates/Case2","picked_particles_directory":"data/Particles/Case2","details":"Movies/Case2 contains unaligned movies for Case2. The files were written as gain-unnormalised integer MRC files by EPU and then converted to TIFF files by mrc2tif in the IMOD suite. During this process, the pixel size in the header was lost. The real pixel size is 1.15 A/px. The dose rates are 1.1 and 2.0 e/A2/frame for low-dose and high-dose datasets, respectively. Please use Movies/Case2/Movie-lowdose/gain.mrc and Movies/Case2/Movie-highdose/gain.mrc, respectively, as gain references without any rotation or flipping.\n\nMicrographs/Case2 contains aligned and summed micrographs.\n\nCoordinates/Case2 contains manually picked filament coordinates for Type I and Type II filaments before any classifications.\n\nParticles/Case2 contains polished \"shiny\" particles used for final reconstructions.","image_width":"3838","image_height":"3710"},{"segmentations":[],"name":"Unaligned movies for Case 3","directory":"data/Movies/Case3","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":3114,"frames_per_image":48,"frame_range_min":1,"frame_range_max":48,"voxel_type":"SIGNED BYTE","pixel_width":1.15,"pixel_height":1.15,"micrographs_file_pattern":"data/Micrographs/Case3","picked_particles_file_pattern":"data/Coordinates/Case3","picked_particles_directory":"data/Particles/Case3","details":"Movies/Case3 contains unaligned movies for Case3. The files were written as gain-unnormalised integer MRC files by EPU and then converted to TIFF files by mrc2tif in the IMOD suite. During this process, the pixel size in the header was lost. The real pixel size is 1.15 A/px. The dose rate is 1.094 e/A2/frame. Please use Movies/Case3/gain.mrc as a gain reference without any rotation or flipping.\n\nMicrographs/Case3 contains aligned and summed micrographs.\n\nCoordinates/Case3 contains manually picked filament coordinates for Type I and Type II filaments before any classifications.\n\nParticles/Case3 contains polished \"shiny\" particles used for final reconstructions.","image_width":"3838","image_height":"3710"}],"workflow_file":null,"grant_references":[],"version_history":[],"title":"Cryo-EM reconstruction of tau filaments extracted from the brains of three individuals with Corticobasal degeneration","principal_investigator":[{"author_orcid":"0000-0002-0462-6540","middle_name":"H.W.","organization":"MRC laboratory of molecular biology","street":"Francis Crick Avenue","town_or_city":"Cambridge","state_or_province":"Cambridgeshire","post_or_zip":"CB2 0QH","telephone":null,"fax":null,"first_name":"Sjors","last_name":"Scheres","email":"scheres [at] mrc-lmb.cam.ac.uk","country":"United Kingdom","entry":"EMPIAR-10340"}],"status":"REL","deposition_date":"2019-11-26","release_date":"2020-03-02","obsolete_date":null,"update_date":"2020-03-02","corresponding_author":{"author":{"author_orcid":"0000-0002-0462-6540","middle_name":"H.W.","organization":"MRC laboratory of molecular biology","street":"Francis Crick Avenue","town_or_city":"Cambridge","state_or_province":"Cambridgeshire","post_or_zip":"CB2 0QH","first_name":"Sjors","last_name":"Scheres","country":"United Kingdom"}},"authors":[{"author":{"name":"Zhang W","author_orcid":"0000-0002-3011-9956"}},{"author":{"name":"Tarutani A","author_orcid":null}},{"author":{"name":"Newell KL","author_orcid":null}},{"author":{"name":"Murzin AG","author_orcid":null}},{"author":{"name":"Matsubara T","author_orcid":null}},{"author":{"name":"Falcon B","author_orcid":"0000-0002-8176-2618"}},{"author":{"name":"Vidal R","author_orcid":null}},{"author":{"name":"Garringer HJ","author_orcid":"0000-0002-1899-7676"}},{"author":{"name":"Shi Y","author_orcid":null}},{"author":{"name":"Ikeuchi T","author_orcid":"0000-0001-8828-8085"}},{"author":{"name":"Murayama S","author_orcid":null}},{"author":{"name":"Ghetti B","author_orcid":"0000-0002-1842-8019"}},{"author":{"name":"Hasegawa M","author_orcid":null}},{"author":{"name":"Goedert M","author_orcid":"0000-0002-5214-7886"}},{"author":{"name":"Scheres SHW","author_orcid":"0000-0002-0462-6540"}}],"cross_references":["EMD-10514","EMD-10512"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Zhang W","author_orcid":"0000-0002-3011-9956"},{"name":"Tarutani A","author_orcid":null},{"name":"Newell KL","author_orcid":null},{"name":"Murzin AG","author_orcid":null},{"name":"Matsubara T","author_orcid":null},{"name":"Falcon B","author_orcid":"0000-0002-8176-2618"},{"name":"Vidal R","author_orcid":null},{"name":"Garringer HJ","author_orcid":"0000-0002-1899-7676"},{"name":"Shi Y","author_orcid":null},{"name":"Ikeuchi T","author_orcid":"0000-0001-8828-8085"},{"name":"Murayama S","author_orcid":null},{"name":"Ghetti B","author_orcid":"0000-0002-1842-8019"},{"name":"Hasegawa M","author_orcid":null},{"name":"Goedert M","author_orcid":"0000-0002-5214-7886"},{"name":"Scheres SHW","author_orcid":"0000-0002-0462-6540"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Novel tau filament fold in corticobasal degeneration","volume":null,"country":"United Kingdom","first_page":null,"last_page":null,"year":"2020","language":"English","doi":"10.1038/s41586-020-2043-0","pubmedid":"32050258","details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Nature","journal_abbreviation":"Nature","issue":null,"preprint":false}],"dataset_size":"2.8 TB","experiment_type":"EMDB","scale":null,"related_pdb_entries":["6tjx","6tjo"],"entry_doi":"10.6019/EMPIAR-10340"}}