{"EMPIAR-10328":{"imagesets":[{"segmentations":[],"name":"Particle stack of Hedgehog receptor PTCH1 in complex with nanobody TI23 for final reconstruction","directory":"data","category":"picked particles - multiframe - processed","header_format":"MRCS","data_format":"MRCS","num_images_or_tilt_series":307652,"frames_per_image":1,"frame_range_min":null,"frame_range_max":null,"voxel_type":"32 BIT FLOAT","pixel_width":1.059,"pixel_height":1.059,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"This is the particle stack for the final reconstruction of PTCH1-TI23 complex. The data sign is +1, white particle on dark background. The accompanying star file is exported from the last round of refinement in cryoSPARC2, with all the CTF parameters recorded.","image_width":"256","image_height":"256"}],"workflow_file":null,"grant_references":[],"version_history":[],"title":"Hedgehog receptor Patched (PTCH1) in complex with a conformation selective nanobody TI23","principal_investigator":[{"author_orcid":"0000-0003-1098-9046","middle_name":"Arden","organization":"Stanford University","street":"265 Campus Drive","town_or_city":"Stanford","state_or_province":"CA","post_or_zip":"94305","telephone":null,"fax":null,"first_name":"Philip","last_name":"Beachy","email":"pbeachy [at] stanford.edu","country":"United States","entry":"EMPIAR-10328"}],"status":"REL","deposition_date":"2019-10-01","release_date":"2021-11-08","obsolete_date":null,"update_date":"2021-11-08","corresponding_author":{"author":{"author_orcid":"0000-0003-2145-4151","middle_name":null,"organization":"Stanford University","street":"265 Campus Drive","town_or_city":"Stanford","state_or_province":"CA","post_or_zip":"94305","first_name":"Yunxiao","last_name":"Zhang","country":"United States"}},"authors":[{"author":{"name":"Zhang Y","author_orcid":"0000-0003-2145-4151"}},{"author":{"name":"Lu WJ","author_orcid":"0000-0002-2186-9800"}},{"author":{"name":"Bulkley DP","author_orcid":"0000-0002-2535-904X"}},{"author":{"name":"Liang J","author_orcid":null}},{"author":{"name":"Ralko A","author_orcid":null}},{"author":{"name":"Han S","author_orcid":null}},{"author":{"name":"Roberts KJ","author_orcid":null}},{"author":{"name":"Li A","author_orcid":null}},{"author":{"name":"Cho W","author_orcid":null}},{"author":{"name":"Cheng Y","author_orcid":"0000-0002-5648-955X"}},{"author":{"name":"Manglik A","author_orcid":"0000-0002-7173-3741"}},{"author":{"name":"Beachy PA","author_orcid":"0000-0003-1098-9046"}}],"cross_references":["EMD-22689"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Zhang Y","author_orcid":"0000-0003-2145-4151"},{"name":"Lu WJ","author_orcid":"0000-0002-2186-9800"},{"name":"Bulkley DP","author_orcid":"0000-0002-2535-904X"},{"name":"Liang J","author_orcid":null},{"name":"Ralko A","author_orcid":null},{"name":"Han S","author_orcid":null},{"name":"Roberts KJ","author_orcid":null},{"name":"Li A","author_orcid":null},{"name":"Cho W","author_orcid":null},{"name":"Cheng Y","author_orcid":"0000-0002-5648-955X"},{"name":"Manglik A","author_orcid":"0000-0002-7173-3741"},{"name":"Beachy PA","author_orcid":"0000-0003-1098-9046"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit","volume":"117","country":"","first_page":"28838","last_page":"28846","year":"2020","language":"English","doi":"10.1073/pnas.2011560117","pubmedid":"33139559","details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Proceedings of the National Academy of Sciences of the United States of America","journal_abbreviation":"Proc Natl Acad Sci U S A","issue":"46","preprint":false}],"dataset_size":"75.2 GB","experiment_type":"EMDB","scale":null,"related_pdb_entries":["7k65"],"entry_doi":"10.6019/EMPIAR-10328"}}