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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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EMD-14201

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Proteasome-ZFAND5 Complex Z+A state

Release date: Feb. 8, 2023
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7qxn
Q-score: 0.319

To Be Published

Sample:

Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 10b (45 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
26s proteasome complex subunit sem1 (8 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
Proteasome-zfand5 complex z+a state (Complex from Homo sapiens)
Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
Isoform 2 of 26s proteasome regulatory subunit 8 (44 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 3 (60 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
26s protease regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)
26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-7 (29 kDa, Protein from Homo sapiens)

[Show more]

EMD-14202

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Proteasome-ZFAND5 Complex Z+B state

Release date: Feb. 8, 2023
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7qxp
Q-score: 0.336

To Be Published

Sample:

26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
26s proteasome complex subunit sem1 (8 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
Isoform 2 of 26s proteasome regulatory subunit 8 (44 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 3 (60 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)
Human proteasome zfand5 complex z+b state (Complex from Homo sapiens)
Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-7 (29 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 10b (45 kDa, Protein from Homo sapiens)

[Show more]

EMD-14203

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Proteasome-ZFAND5 Complex Z+C state

Release date: Feb. 8, 2023
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7qxu
Q-score: 0.233

To Be Published

Sample:

26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from human)
Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from human)
26s protease regulatory subunit 6a (49 kDa, Protein from human)
Proteasome subunit alpha type-7 (27 kDa, Protein from human)
Proteasome subunit alpha type-3 (28 kDa, Protein from human)
Proteasome subunit beta type-1 (26 kDa, Protein from human)
26s proteasome regulatory subunit 8 (43 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from human)
26s proteasome regulatory subunit 4 (48 kDa, Protein from human)
Magnesium ion (24 Da, Ligand)
Proteasome subunit beta type-2 (22 kDa, Protein from human)
Adenosine-5'-diphosphate (427 Da, Ligand)
Proteasome subunit alpha type-6 (27 kDa, Protein from human)
Proteasome subunit alpha type-4 (29 kDa, Protein from human)
Proteasome subunit alpha type-2 (25 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from human)
26s protease regulatory subunit 7 (48 kDa, Protein from human)
Proteasome subunit beta type-4 (29 kDa, Protein from human)
Proteasome subunit beta type-6 (25 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from human)
Proteasome subunit beta type-7 (29 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from human)
Proteasome subunit beta type-5 (28 kDa, Protein from human)
Human proteasome zfand5 complex z+c state (Complex from Homo sapiens)
26s proteasome complex subunit sem1 (8 kDa, Protein from human)
Adenosine-5'-triphosphate (507 Da, Ligand)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from human)
26s proteasome regulatory subunit 10b (45 kDa, Protein from human)
Zinc ion (65 Da, Ligand)
26s proteasome non-atpase regulatory subunit 3 (60 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from human)
26s protease regulatory subunit 6b (47 kDa, Protein from human)
Proteasome subunit alpha type-5 (26 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from human)
Proteasome subunit beta type-3 (22 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from human)

[Show more]

EMD-14204

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Proteasome-ZFAND5 Complex Z+D state

Release date: Feb. 8, 2023
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7qxw
Q-score: 0.267

To Be Published

Sample:

26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from human)
Proteasome subunit beta type-5 (28 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from human)
An1-type zinc finger protein 5 (23 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-4 (29 kDa, Protein from human)
Magnesium ion (24 Da, Ligand)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from human)
26s proteasome regulatory subunit 10b (45 kDa, Protein from human)
Proteasome subunit alpha type-5 (26 kDa, Protein from human)
Adenosine-5'-diphosphate (427 Da, Ligand)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from human)
Proteasome subunit beta type-4 (29 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from human)
Isoform 2 of 26s proteasome regulatory subunit 8 (44 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from human)
Proteasome subunit alpha type-6 (27 kDa, Protein from human)
Proteasome subunit alpha type-7 (27 kDa, Protein from human)
26s protease regulatory subunit 6a (49 kDa, Protein from human)
26s proteasome regulatory subunit 4 (48 kDa, Protein from human)
Zinc ion (65 Da, Ligand)
Proteasome subunit beta type-1 (26 kDa, Protein from human)
26s protease regulatory subunit 7 (48 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 3 (60 kDa, Protein from human)
26s proteasome complex subunit sem1 (8 kDa, Protein from human)
Proteasome subunit beta type-6 (25 kDa, Protein from human)
Human proteasome zfand5 complex z+d state (Complex from Homo sapiens)
Proteasome subunit beta type-3 (22 kDa, Protein from human)
Adenosine-5'-triphosphate (507 Da, Ligand)
26s protease regulatory subunit 6b (47 kDa, Protein from human)
Proteasome subunit beta type-2 (22 kDa, Protein from human)
Proteasome subunit alpha type-2 (25 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from human)
Proteasome subunit alpha type-3 (28 kDa, Protein from human)
Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from human)
Proteasome subunit beta type-7 (29 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from human)

[Show more]

EMD-14205

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Proteasome-ZFAND5 Complex Z+E state

Release date: Feb. 8, 2023
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7qxx
Q-score: 0.233

To Be Published

Sample:

26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from human)
26s proteasome regulatory subunit 4 (48 kDa, Protein from human)
Zinc ion (65 Da, Ligand)
Proteasome subunit beta type-7 (29 kDa, Protein from human)
Proteasome subunit alpha type-2 (25 kDa, Protein from human)
Proteasome subunit beta type-2 (22 kDa, Protein from human)
Human proteasome zfand5 complex z+b state (Complex from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
26s protease regulatory subunit 6a (49 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from human)
Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from human)
26s protease regulatory subunit 6b (47 kDa, Protein from human)
Proteasome subunit beta type-5 (28 kDa, Protein from human)
Proteasome subunit alpha type-5 (26 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from human)
26s proteasome regulatory subunit 8 (43 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from human)
Adenosine-5'-triphosphate (507 Da, Ligand)
Proteasome subunit alpha type-7 (27 kDa, Protein from human)
Magnesium ion (24 Da, Ligand)
26s proteasome complex subunit sem1 (8 kDa, Protein from human)
26s proteasome regulatory subunit 10b (45 kDa, Protein from human)
Proteasome subunit alpha type-6 (27 kDa, Protein from human)
26s protease regulatory subunit 7 (48 kDa, Protein from human)
Proteasome subunit alpha type-3 (28 kDa, Protein from human)
Proteasome subunit alpha type-4 (29 kDa, Protein from human)
Proteasome subunit beta type-4 (29 kDa, Protein from human)
Proteasome subunit beta type-6 (25 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from human)
Proteasome subunit beta type-1 (26 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 3 (60 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from human)
Proteasome subunit beta type-3 (22 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from human)

[Show more]

EMD-14209

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Proteasome-ZFAND5 Complex Z-A state

Release date: Feb. 8, 2023
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7qy7
Q-score: 0.193

To Be Published

Sample:

26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from human)
26s protease regulatory subunit 6b (47 kDa, Protein from human)
Proteasome subunit alpha type-6 (27 kDa, Protein from human)
Proteasome subunit alpha type-3 (28 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from human)
Proteasome subunit alpha type-2 (25 kDa, Protein from human)
Human proteasome zfand5 complex z-a state (Complex from Homo sapiens)
Proteasome subunit alpha type-4 (29 kDa, Protein from human)
Proteasome subunit beta type-6 (25 kDa, Protein from human)
Proteasome subunit beta type-5 (28 kDa, Protein from human)
26s protease regulatory subunit 6a (49 kDa, Protein from human)
Psmc5 isoform 15 (44 kDa, Protein from human)
Proteasome subunit beta type-7 (29 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from human)
26s protease regulatory subunit 4 (49 kDa, Protein from human)
26s proteasome complex subunit sem1 (8 kDa, Protein from human)
Proteasome subunit alpha type-7 (27 kDa, Protein from human)
Proteasome subunit beta type-4 (29 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 3 (60 kDa, Protein from human)
Proteasome subunit beta type-3 (22 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from human)
26s protease regulatory subunit 7 (48 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from human)
Proteasome subunit beta type-1 (26 kDa, Protein from human)
26s proteasome regulatory subunit 10b (45 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from human)
Proteasome subunit beta type-2 (22 kDa, Protein from human)
Zinc ion (65 Da, Ligand)
Proteasome subunit alpha type-5 (26 kDa, Protein from human)
Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from human)
Adenosine-5'-triphosphate (507 Da, Ligand)

[Show more]

EMD-14210

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Proteasome-ZFAND5 Complex Z-B state

Release date: Feb. 8, 2023
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 7qya
Q-score: 0.176

To Be Published

Sample:

26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from human)
Zinc ion (65 Da, Ligand)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from human)
26s protease regulatory subunit 6a (49 kDa, Protein from human)
Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from human)
Proteasome subunit beta type-2 (22 kDa, Protein from human)
Proteasome subunit alpha type-7 (27 kDa, Protein from human)
Isoform 2 of 26s proteasome regulatory subunit 8 (44 kDa, Protein from human)
Proteasome subunit beta type-3 (22 kDa, Protein from human)
26s protease regulatory subunit 7 (48 kDa, Protein from human)
Proteasome subunit alpha type-3 (28 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from human)
Human proteasome zfand5 complex z-b state (Complex from Homo sapiens)
Proteasome subunit alpha type-4 (29 kDa, Protein from human)
Proteasome subunit beta type-5 (28 kDa, Protein from human)
Proteasome subunit beta type-6 (25 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from human)
26s proteasome complex subunit sem1 (8 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from human)
26s protease regulatory subunit 4 (49 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from human)
26s protease regulatory subunit 6b (47 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from human)
26s proteasome regulatory subunit 10b (45 kDa, Protein from human)
Proteasome subunit beta type-7 (29 kDa, Protein from human)
Proteasome subunit beta type-1 (26 kDa, Protein from human)
Proteasome subunit alpha type-2 (25 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from human)
Proteasome subunit alpha type-5 (26 kDa, Protein from human)
Proteasome subunit alpha type-6 (27 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 3 (60 kDa, Protein from human)
Proteasome subunit beta type-4 (29 kDa, Protein from human)
Adenosine-5'-triphosphate (507 Da, Ligand)

[Show more]

EMD-14211

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Proteasome-ZFAND5 Complex Z-C state

Release date: Feb. 8, 2023
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7qyb
Q-score: 0.252

To Be Published

Sample:

Human proteasome zfand5 complex z-c state (Complex from Homo sapiens)
26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from human)
Zinc ion (65 Da, Ligand)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from human)
26s protease regulatory subunit 6a (49 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from human)
Magnesium ion (24 Da, Ligand)
26s protease regulatory subunit 7 (48 kDa, Protein from human)
Isoform 2 of 26s proteasome regulatory subunit 8 (44 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 3 (60 kDa, Protein from human)
26s proteasome complex subunit sem1 (8 kDa, Protein from human)
Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from human)
26s protease regulatory subunit 4 (49 kDa, Protein from human)
Proteasome subunit beta type-1 (26 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from human)
Proteasome subunit beta type-6 (25 kDa, Protein from human)
Adenosine-5'-triphosphate (507 Da, Ligand)
26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from human)
Proteasome subunit beta type-5 (28 kDa, Protein from human)
Proteasome subunit alpha type-5 (26 kDa, Protein from human)
Proteasome subunit beta type-4 (29 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from human)
Proteasome subunit beta type-2 (22 kDa, Protein from human)
26s protease regulatory subunit 6b (47 kDa, Protein from human)
Adenosine-5'-diphosphate (427 Da, Ligand)
Proteasome subunit alpha type-3 (28 kDa, Protein from human)
Proteasome subunit alpha type-7 (27 kDa, Protein from human)
Proteasome subunit alpha type-4 (29 kDa, Protein from human)
Proteasome subunit beta type-7 (29 kDa, Protein from human)
Proteasome subunit alpha type-6 (27 kDa, Protein from human)
Proteasome subunit alpha type-2 (25 kDa, Protein from human)
Proteasome subunit beta type-3 (22 kDa, Protein from human)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from human)
26s proteasome regulatory subunit 10b (45 kDa, Protein from human)

[Show more]

EMD-14251

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Bovine complex I in the presence of IM1761092, active class i (Composite map)

Release date: Feb. 8, 2023
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 7r41
Q-score: 0.686

Bridges HR, Blaza JN, Yin Z, Chung I, Pollak MN, Hirst J

Science (2023) 379 pp. 351-357 [ Pubmed: 36701435 DOI: doi:10.1126/science.ade3332 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from cattle)
Acyl carrier protein, mitochondrial (17 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (39 kDa, Protein from cattle)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Nadh ubiquinone oxidoreductase (complex i) (1 MDa, Complex from Bos taurus)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from cattle)
~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from cattle)
1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine (365 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (42 kDa, Protein from cattle)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from cattle)
Myristic acid (228 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from cattle)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from cattle)
Dodecyl-beta-d-maltoside (510 Da, Ligand)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (15 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (21 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (11 kDa, Protein from cattle)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from cattle)
Magnesium ion (24 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from cattle)
1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from cattle)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (23 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (12 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (23 kDa, Protein from cattle)
Iron/sulfur cluster (351 Da, Ligand)
Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from cattle)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (52 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from cattle)
Guanosine-5'-triphosphate (523 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from cattle)
Potassium ion (39 Da, Ligand)
Cardiolipin (1 kDa, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from cattle)
Zinc ion (65 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from cattle)
Water (18 Da, Ligand)

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EMD-14256

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Bovine complex I in the presence of IM1761092, active class ii (Composite map)

Release date: Feb. 8, 2023
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 7r42
Q-score: 0.697

Bridges HR, Blaza JN, Yin Z, Chung I, Pollak MN, Hirst J

Science (2023) 379 pp. 351-357 [ Pubmed: 36701435 DOI: doi:10.1126/science.ade3332 ]

Sample:

Acyl carrier protein, mitochondrial (17 kDa, Protein from cattle)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from cattle)
Potassium ion (39 Da, Ligand)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (21 kDa, Protein from cattle)
Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from cattle)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (23 kDa, Protein from cattle)
Iron/sulfur cluster (351 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (15 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (52 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from cattle)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (11 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (23 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from cattle)
Magnesium ion (24 Da, Ligand)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from cattle)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from cattle)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Water (18 Da, Ligand)
Cardiolipin (1 kDa, Ligand)
Flavin mononucleotide (456 Da, Ligand)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from cattle)
Nadh ubiquinone oxidoreductase (complex i) (1 MDa, Complex from Bos taurus)
1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine (365 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (12 kDa, Protein from cattle)
Guanosine-5'-triphosphate (523 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from cattle)
Dodecyl-beta-d-maltoside (510 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (39 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from cattle)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from cattle)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from cattle)
1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Myristic acid (228 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (42 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from cattle)
~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from cattle)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from cattle)

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