Cryo-EM structure of CD38 in complex with FTL004
Resolution: 3.86 Å
EM Method: Single-particle
Fitted PDBs: 8il3
Q-score: 0.387
Zhang G, Guo C, Wang Y, Zhang X, Liu S, Qu W, Chen C, Yan L, Yang Z, Zhang Z, Jiang X, Chen X, Liu H, Lai Q, Wei X, Lu Y, Zhao S, Deng H, Wang Y, Yu L, Yu H, Wu Y, Su Z, Chen P, Ren Z, Yu M, Qu F, Luo Y, Gou L, Li Q, Huang Y, Ma F, Yang J
J Hematol Oncol (2022) 15 pp. 177-177 [ Pubmed: 36581954 DOI: doi:10.1186/s13045-022-01395-0 ]
- Adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 (26 kDa, Protein from Homo sapiens)
- Cryo-em structure of cd38 in complex with ftl004 (Complex from Homo sapiens)
- Light chain (23 kDa, Protein from Homo sapiens)
- Heavy chain (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of LPS-bound GPR174 in complex with Gs protein
Liang J, Inoue A, Ikuta T, Xia R, Wang N, Kawakami K, Xu Z, Qian Y, Zhu X, Zhang A, Guo C, Huang Z, He Y
Nat Commun (2023) 14 pp. 1012-1012 [ DOI: doi:10.1038/s41467-023-36575-0 Pubmed: 36823105 ]
- (2~{s})-2-$l^{4}-azanyl-3-[[(2~{r})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid (497 Da, Ligand)
- Probable g-protein coupled receptor 174 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Nb35 (17 kDa, Protein from Lama glama)
- Gpr174/gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Engineered g protein subunit s (mini-gs) (41 kDa, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8e4y
Q-score: 0.502
Johnson ZL, Ammirati M, Wasilko DJ, Chang JS, Noell S, Foley TL, Yoon H, Smith K, Asano S, Hales K, Wan M, Yang Q, Piotrowski MA, Farley KA, Gilbert T, Aschenbrenner LM, Fennell KF, Dutra JK, Xu M, Guo C, Varghese AE, Bellenger J, Quinn A, Am Ende CW, West GM, Griffor MC, Bennett D, Calabrese M, Steppan CM, Han S, Wu H
Nat Struct Mol Biol (2023) 30 pp. 22-30 [ DOI: doi:10.1038/s41594-022-00884-7 Pubmed: 36522428 ]
- Glycerol-3-phosphate acyltransferase 1, mitochondrial (86 kDa, Protein from Homo sapiens)
- (2r)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate (410 Da, Ligand)
- [(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl (3r)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(2-oxohexadecyl)sulfanyl]ethyl}amino)propyl]amino}butyl dihydrogen diphosphate (non-preferred name) (1 kDa, Ligand)
- Glycerol-3-phosphate acyltransferase 1 (86 kDa, Complex from Homo sapiens)
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8e50
Q-score: 0.444
Johnson ZL, Ammirati M, Wasilko DJ, Chang JS, Noell S, Foley TL, Yoon H, Smith K, Asano S, Hales K, Wan M, Yang Q, Piotrowski MA, Farley KA, Gilbert T, Aschenbrenner LM, Fennell KF, Dutra JK, Xu M, Guo C, Varghese AE, Bellenger J, Quinn A, Am Ende CW, West GM, Griffor MC, Bennett D, Calabrese M, Steppan CM, Han S, Wu H
Nat Struct Mol Biol (2023) 30 pp. 22-30 [ DOI: doi:10.1038/s41594-022-00884-7 Pubmed: 36522428 ]
- Glycerol-3-phosphate acyltransferase 1, mitochondrial (86 kDa, Protein from Homo sapiens)
- (2r)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate (410 Da, Ligand)
- Coenzyme a (767 Da, Ligand)
- Glycerol-3-phosphate acyltransferase 1 (86 kDa, Complex from Homo sapiens)
huamn bile salt exporter ABCB11 with N-terminal truncated
Wang L, Hou WT, Wang J, Xu D, Guo C, Sun L, Ruan K, Zhou CZ, Chen Y
Cell Res (2022) 32 pp. 501-504 [ DOI: doi:10.1038/s41422-021-00611-9 Pubmed: 35043010 ]
- Abcb11 (Cellular component from Homo sapiens)
- Human abcb11 (Protein from Homo sapiens)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7x10
Q-score: 0.465
Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y
Mol Cell (2022) 82 pp. 4340-4352.e6 [ DOI: doi:10.1016/j.molcel.2022.10.009 Pubmed: 36309016 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Engineered g alpha 12 subunit (39 kDa, Protein from Homo sapiens)
- Isoform 3 of adhesion g protein-coupled receptor l3 (172 kDa, Protein from Mus musculus)
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7wy5
Q-score: 0.514
Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y
Mol Cell (2022) 82 pp. 4340-4352.e6 [ DOI: doi:10.1016/j.molcel.2022.10.009 Pubmed: 36309016 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nb35 (17 kDa, Protein from Homo sapiens)
- Isoform 3 of adhesion g protein-coupled receptor l3 (172 kDa, Protein from Mus musculus)
- Engineered mini g alpha q subunit (41 kDa, Protein from Homo sapiens)
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7wy8
Q-score: 0.504
Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y
Mol Cell (2022) 82 pp. 4340-4352.e6 [ DOI: doi:10.1016/j.molcel.2022.10.009 Pubmed: 36309016 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered mini g alpha s subunit (41 kDa, Protein from Homo sapiens)
- Nb35 (17 kDa, Protein from Lama glama)
- Gpcr/g-protein (Complex from Lama glama)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nb35 (Complex)
- Isoform 3 of adhesion g protein-coupled receptor l3 (172 kDa, Protein from Mus musculus)
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7wyb
Q-score: 0.352
Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y
Mol Cell (2022) 82 pp. 4340-4352.e6 [ DOI: doi:10.1016/j.molcel.2022.10.009 Pubmed: 36309016 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Adgrl3 (Complex from Mus musculus)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex)
- Isoform 3 of adhesion g protein-coupled receptor l3 (172 kDa, Protein from Mus musculus)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7wxu
Q-score: 0.533
Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y
Nat Commun (2022) 13 pp. 5513-5513 [ Pubmed: 36127364 DOI: doi:10.1038/s41467-022-33173-4 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nb35 (17 kDa, Protein from Lama glama)
- Gpcr/g-protein (Complex from Lama glama)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Adhesion g-protein coupled receptor f1 (101 kDa, Protein from Homo sapiens)
- Engineered mini galpha-q subunit (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nb35 (Complex)