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sample_name:"human excitatory amino acid transporter 3"

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Current Database

  • EMDB [13]

Current status

  • REL [13]

Sample type

  • Complex [13]
  • Protein [13]
  • Ligand [5]

Organism

  • Homo sapiens [13]

EM Method

  • Single-particle [13]

Resolution

  • ≥ 2Å and < 3Å [8]
  • ≥ 3Å and < 4Å [5]

Model molecular weight

  • 50-100 kDa [5]

Release Date

  • 2026 [2]
  • 2025 [5]
  • 2023 [3]
  • 2021 [3]

Author by name

  • Boudker O [13]
  • Qiu B [13]
  • Chakraborty AA [5]
  • Coker JA [5]
  • Earsley A [5]
  • Goins CM [5]
  • Koochaki P [5]
  • Romigh T [5]
  • Stauffer SR [5]
  • Wang NS [5]
  • Fortea E [3]
  • Matthies D [3]
  • Yu Z [3]
  • Bauer JA [2]
  • Days E [2]
  • Mi D [2]
  • Salem C [2]

Author by ORCID

  • Qiu B [10]
  • Boudker O [5]
  • Chakraborty AA [2]
  • Stauffer SR [2]
  • Coker JA [2]
  • Earsley A [2]

Journal

  • BIORXIV [5]
  • TO BE PUBLISHED [4]
  • EMBO J [2]
  • NAT COMMUN [2]

Software

  • CRYOSPARC [10]
  • RELION [6]

Microscope

  • FEI TITAN KRIOS [6]
  • TFS KRIOS [5]
  • FEI/PHILIPS CM300FEG/T [2]

Electron Source

  • FIELD EMISSION GUN [13]

Film or detector model

  • GATAN K3 6K X 4K [8]
  • GATAN K3 BIOQUANTUM 6K X 4K [4]
  • GATAN K2 SUMMIT 4K X 4K [1]

External links

  • PDB [13]
  • AlphaFold DB [12]
  • UniProt [12]
  • PDBe-Kb [10]
  • ChEBI [5]
  • Complex Portal [5]
  • DrugBank [5]
  • Gene Ontology [5]
  • InterPro [5]
  • Pfam [5]
  • ChEMBL [4]
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EMD-75049
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Human Excitatory Amino Acid Transporter 3 in 300 mM potassium and 0.1 mM Cmpd 3e in the outward-facing OFS state
CryoEM
Release date: May 27, 2026
Resolution: 3.24 Å
EM Method: Single-particle

Koochaki P, Qiu B, Coker JA, Earsley A, Wang NS, Romigh T, Goins CM, Salem C, Mi D, Days E, Bauer JA, Stauffer SR, Boudker O, Chakraborty AA

EMBO J (2026) 45 pp. 3763-3787 [ DOI: doi:10.1038/s44318-026-00776-2 Pubmed: 42020573 ]

EMD-75048
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Human Excitatory Amino Acid Transporter 3 in 300 mM potassium and 0.1 mM Cmpd 3e in the intermediate outward-facing iOFS state
CryoEM
Release date: May 6, 2026
Resolution: 3.11 Å
EM Method: Single-particle

Koochaki P, Qiu B, Coker JA, Earsley A, Wang NS, Romigh T, Goins CM, Salem C, Mi D, Days E, Bauer JA, Stauffer SR, Boudker O, Chakraborty AA

EMBO J (2026) 45 pp. 3763-3787 [ DOI: doi:10.1038/s44318-026-00776-2 Pubmed: 42020573 ]

EMD-71288
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Human EAAT3 with compound 3e and cholesterol bound at inward facing state
CryoEM
Release date: July 30, 2025
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 9p4x
Q-score: 0.577

Koochaki P, Qiu B, Coker JA, Earsley A, Wang NS, Romigh T, Goins CM, Stauffer SR, Boudker O, Chakraborty AA

bioRxiv (2025) [ Pubmed: 40672197 DOI: doi:10.1101/2025.07.03.663021 ]

EMD-71289
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Human EAAT3 with compound 3e and digitonin.glyco-diosgenin bound at inward facing state
CryoEM
Release date: July 30, 2025
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 9p4y
Q-score: 0.616

Koochaki P, Qiu B, Coker JA, Earsley A, Wang NS, Romigh T, Goins CM, Stauffer SR, Boudker O, Chakraborty AA

bioRxiv (2025) [ Pubmed: 40672197 DOI: doi:10.1101/2025.07.03.663021 ]

EMD-71290
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Human EAAT3 with sodium bound at inward facing state
CryoEM
Release date: July 30, 2025
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 9p4z
Q-score: 0.531

Koochaki P, Qiu B, Coker JA, Earsley A, Wang NS, Romigh T, Goins CM, Stauffer SR, Boudker O, Chakraborty AA

bioRxiv (2025) [ Pubmed: 40672197 DOI: doi:10.1101/2025.07.03.663021 ]

EMD-46587
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EAAT3 in 200 mM NaCl and 10 mM R-2-hydroxyglutarate buffer at OFS.
CryoEM
Release date: Jan. 22, 2025
Resolution: 3.07 Å
EM Method: Single-particle

Qiu B, Boudker O

bioRxiv (2024) [ DOI: doi:10.1101/2024.09.05.611541 Pubmed: 39282329 ]

EMD-46592
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Human excitatory amino acid transporter 3 EAAT3 monomer in 200 mM NaCl, 10 mM L-Cysteine at IFS
CryoEM
Release date: Jan. 22, 2025
Resolution: 2.94 Å
EM Method: Single-particle

Qiu B, Boudker O

bioRxiv (2024) [ DOI: doi:10.1101/2024.09.05.611541 Pubmed: 39282329 ]

EMD-26980
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Human excitatory amino acid transporter 3 in inward facing state in 100 mM L-glutamate
CryoEM
Release date: May 17, 2023
Resolution: 2.89 Å
EM Method: Single-particle

Qiu B, Boudker O

To Be Published

EMD-26998
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Human excitatory amino acid transporter 3 EAAT3 protomer in an outward facing apo state in 300 mM KCl
CryoEM
Release date: May 10, 2023
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8cud
Q-score: 0.541

Qiu B, Boudker O

Nat Commun (2023) 14 pp. 2579-2579 [ DOI: doi:10.1038/s41467-023-38120-5 Pubmed: 37142617 ]

EMD-27007
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Human Excitatory excitatory amino acid transporter 3 EAAT3 protomer at in an intermediate outward facing sodium-bound state
CryoEM
Release date: May 10, 2023
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8cv3
Q-score: 0.557

Qiu B, Boudker O

Nat Commun (2023) 14 pp. 2579-2579 [ DOI: doi:10.1038/s41467-023-38120-5 Pubmed: 37142617 ]

Sort by: Download
Showing 1 - 10 of 13. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [13]

Current status

  • REL [13]

Sample type

  • Complex [13]
  • Protein [13]
  • Ligand [5]

Organism

  • Homo sapiens [13]

EM Method

  • Single-particle [13]

Resolution

  • ≥ 2Å and < 3Å [8]
  • ≥ 3Å and < 4Å [5]

Model molecular weight

  • 50-100 kDa [5]

Release Date

  • 2026 [2]
  • 2025 [5]
  • 2023 [3]
  • 2021 [3]

Author by name

  • Boudker O [13]
  • Qiu B [13]
  • Chakraborty AA [5]
  • Coker JA [5]
  • Earsley A [5]
  • Goins CM [5]
  • Koochaki P [5]
  • Romigh T [5]
  • Stauffer SR [5]
  • Wang NS [5]
  • Fortea E [3]
  • Matthies D [3]
  • Yu Z [3]
  • Bauer JA [2]
  • Days E [2]
  • Mi D [2]
  • Salem C [2]

Author by ORCID

  • Qiu B [10]
  • Boudker O [5]
  • Chakraborty AA [2]
  • Stauffer SR [2]
  • Coker JA [2]
  • Earsley A [2]

Journal

  • BIORXIV [5]
  • TO BE PUBLISHED [4]
  • EMBO J [2]
  • NAT COMMUN [2]

Software

  • CRYOSPARC [10]
  • RELION [6]

Microscope

  • FEI TITAN KRIOS [6]
  • TFS KRIOS [5]
  • FEI/PHILIPS CM300FEG/T [2]

Electron Source

  • FIELD EMISSION GUN [13]

Film or detector model

  • GATAN K3 6K X 4K [8]
  • GATAN K3 BIOQUANTUM 6K X 4K [4]
  • GATAN K2 SUMMIT 4K X 4K [1]

External links

  • PDB [13]
  • AlphaFold DB [12]
  • UniProt [12]
  • PDBe-Kb [10]
  • ChEBI [5]
  • Complex Portal [5]
  • DrugBank [5]
  • Gene Ontology [5]
  • InterPro [5]
  • Pfam [5]
  • ChEMBL [4]