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sample_name:"Cysteine-free Insulin-degrading enzyme"

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Current Database

  • EMDB [6]

Current status

  • REL [6]

Sample type

  • Complex [6]
  • Protein [6]

Organism

  • Homo sapiens [6]

EM Method

  • Single-particle [6]

Resolution

  • ≥ 3Å and < 4Å [4]
  • ≥ 4Å and < 5Å [1]
  • ≥ 5Å and < 6Å [1]

Model molecular weight

  • 100-250 kDa [6]

Release Date

  • 2026 [1]
  • 2022 [5]

Author by name

  • Carragher B [6]
  • Liang WG [6]
  • Mancl JM [6]
  • Potter CS [6]
  • Tang WJ [6]
  • Wei H [6]
  • Bayhi NL [5]
  • Budell W [5]
  • Mendez JH [5]
  • Sosnick TR [5]

Author by ORCID

  • Mancl JM [1]

Journal

  • ELIFE [6]

Software

  • RELION [1]

Microscope

  • FEI TITAN KRIOS [5]
  • TFS KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [6]

Film or detector model

  • GATAN K3 6K X 4K [5]
  • GATAN K2 SUMMIT 4K X 4K [1]

External links

  • AlphaFold DB [6]
  • Complex Portal [6]
  • PDB [6]
  • PDBe-Kb [6]
  • Pfam [6]
  • UniProt [6]
  • Gene Ontology [5]
  • InterPro [5]
  • EMPIAR [1]
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EMD-72393
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Raw data
EMPIAR-12968
Insulin Degrading Enzyme Time-resolved O/O state
CryoEM
Release date: May 6, 2026
Resolution: 5.1 Å
EM Method: Single-particle
Fitted PDBs: 9y0h
Q-score: 0.047

Mancl JM, Liang WG, Wei H, Carragher B, Potter CS, Tang WJ

eLife (2025) [ DOI: doi:10.7554/eLife.105761.1 ]

EMD-24757
Download Map
3D View
Insulin Degrading Enzyme pO/pC
CryoEM
Release date: Aug. 31, 2022
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7rze
Q-score: 0.47

Mancl JM, Liang WG, Bayhi NL, Wei H, Budell W, Mendez JH, Sosnick TR, Carragher B, Potter CS, Tang WJ

eLife (2026) [ DOI: doi:10.7554/elife.105761.3 ]

EMD-24758
Download Map
3D View
Insulin Degrading Enzyme O/pC
CryoEM
Release date: Aug. 31, 2022
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7rzf
Q-score: 0.417

Mancl JM, Liang WG, Bayhi NL, Wei H, Budell W, Mendez JH, Sosnick TR, Carragher B, Potter CS, Tang WJ

eLife (2026) [ DOI: doi:10.7554/elife.105761.3 ]

EMD-24759
Download Map
3D View
Insulin Degrading Enzyme O/pO
CryoEM
Release date: Aug. 31, 2022
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7rzg
Q-score: 0.329

Mancl JM, Liang WG, Bayhi NL, Wei H, Budell W, Mendez JH, Sosnick TR, Carragher B, Potter CS, Tang WJ

eLife (2026) [ DOI: doi:10.7554/elife.105761.3 ]

EMD-24760
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Insulin Degrading Enzyme O/O
CryoEM
Release date: Aug. 31, 2022
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7rzh
Q-score: 0.234

Mancl JM, Liang WG, Bayhi NL, Wei H, Budell W, Mendez JH, Sosnick TR, Carragher B, Potter CS, Tang WJ

eLife (2026) [ DOI: doi:10.7554/elife.105761.3 ]

EMD-24761
Download Map
3D View
Insulin Degrading Enzyme pC/pC
CryoEM
Release date: Aug. 31, 2022
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7rzi
Q-score: 0.54

Mancl JM, Liang WG, Bayhi NL, Wei H, Budell W, Mendez JH, Sosnick TR, Carragher B, Potter CS, Tang WJ

eLife (2026) [ DOI: doi:10.7554/elife.105761.3 ]

Sort by: Download
Showing 1 - 6 of 6. Page 1 of 1
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [6]

Current status

  • REL [6]

Sample type

  • Complex [6]
  • Protein [6]

Organism

  • Homo sapiens [6]

EM Method

  • Single-particle [6]

Resolution

  • ≥ 3Å and < 4Å [4]
  • ≥ 4Å and < 5Å [1]
  • ≥ 5Å and < 6Å [1]

Model molecular weight

  • 100-250 kDa [6]

Release Date

  • 2026 [1]
  • 2022 [5]

Author by name

  • Carragher B [6]
  • Liang WG [6]
  • Mancl JM [6]
  • Potter CS [6]
  • Tang WJ [6]
  • Wei H [6]
  • Bayhi NL [5]
  • Budell W [5]
  • Mendez JH [5]
  • Sosnick TR [5]

Author by ORCID

  • Mancl JM [1]

Journal

  • ELIFE [6]

Software

  • RELION [1]

Microscope

  • FEI TITAN KRIOS [5]
  • TFS KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [6]

Film or detector model

  • GATAN K3 6K X 4K [5]
  • GATAN K2 SUMMIT 4K X 4K [1]

External links

  • AlphaFold DB [6]
  • Complex Portal [6]
  • PDB [6]
  • PDBe-Kb [6]
  • Pfam [6]
  • UniProt [6]
  • Gene Ontology [5]
  • InterPro [5]
  • EMPIAR [1]