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sample_name:"Complex of LRRK2 with GZD-824 and Darpin bound"

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  • Alegrio Louro J [1]
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  • Leschziner A [1]
  • Leschziner AE [1]
  • Mathea S [1]
  • Sanz Murillo M [1]
  • Sanz-murillo M [1]
  • Villagran Suarez A [1]
  • Villagran-suarez A [1]

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  • Knapp S [1]
  • Mathea S [1]
  • Alegrio Louro J [1]
  • Sanz Murillo M [1]
  • Leschziner AE [1]
  • Villagran Suarez A [1]
  • Dederer V [1]

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EMD-41757
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EMPIAR-11869
Structure of full length LRRK2 bound to GZD-824 I2020T mutant
Release date: Dec. 6, 2023
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8tzf
Q-score: 0.46

Sanz Murillo M, Villagran Suarez A, Dederer V, Chatterjee D, Alegrio Louro J, Knapp S, Mathea S, Leschziner AE

Sci Adv (2023) 9 pp. eadk6191-eadk6191 [ DOI: doi:10.1126/sciadv.adk6191 Pubmed: 38039358 ]

Sort by: Download
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Filter By

Current Database

  • EMDB [1]

Current status

  • REL [1]

Sample type

  • Complex [1]
  • Ligand [1]
  • Protein [1]

Organism

  • Synthetic construct [1]
  • Homo sapiens [1]

EM Method

  • Single-particle [1]

Resolution

  • ≥ 3Å and < 4Å [1]

Model molecular weight

  • 250-500 kDa [1]

Release Date

  • 2023 [1]

Author by name

  • Alegrio Louro J [1]
  • Alegrio-louro J [1]
  • Chatterjee D [1]
  • Dederer V [1]
  • Knapp S [1]
  • Leschziner A [1]
  • Leschziner AE [1]
  • Mathea S [1]
  • Sanz Murillo M [1]
  • Sanz-murillo M [1]
  • Villagran Suarez A [1]
  • Villagran-suarez A [1]

Author by ORCID

  • Knapp S [1]
  • Mathea S [1]
  • Alegrio Louro J [1]
  • Sanz Murillo M [1]
  • Leschziner AE [1]
  • Villagran Suarez A [1]
  • Dederer V [1]

Journal

  • SCI ADV [1]

Software

  • CRYOSPARC [1]

Microscope

  • FEI TALOS ARCTICA [1]

Electron Source

  • FIELD EMISSION GUN [1]

Film or detector model

  • FEI FALCON IV 4K X 4K [1]

External links

  • AlphaFold DB [1]
  • ChEBI [1]
  • ChEMBL [1]
  • DrugBank [1]
  • EMPIAR [1]
  • Gene Ontology [1]
  • InterPro [1]
  • PDB [1]
  • PDBe-Kb [1]
  • Pfam [1]
  • UniProt [1]