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primary_citation_author:"Fajtova P"

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Current Database

  • EMDB [9]

Current status

  • REL [9]

Sample type

  • Protein [9]
  • Complex [8]
  • Ligand [7]
  • Cellular component [1]

Organism

  • Plasmodium falciparum [3]
  • Homo sapiens [3]
  • Trichomonas vaginalis [2]
  • Plasmodium falciparum [1]

EM Method

  • Single-particle [9]

Resolution

  • ≥ 2Å and < 3Å [6]
  • ≥ 3Å and < 4Å [3]

Model molecular weight

  • 250-500 kDa [1]
  • 500-1000 kDa [8]

Release Date

  • 2026 [3]
  • 2025 [4]
  • 2024 [2]

Author by name

  • Fajtova P [9]
  • O Donoghue Aj [8]
  • Boura E [4]
  • Silhan J [4]
  • Zhang H [3]
  • Zhao J [3]
  • Almaliti J [2]
  • Bartosova J [2]
  • Bogyo M [2]
  • Buchwald NH [2]
  • Derisi JL [2]
  • Eckmann L [2]
  • Fei F [2]
  • Gerwick WH [2]
  • Gestwicki JE [2]
  • Gu X [2]
  • Hurysz BM [2]
  • Melo A [2]
  • Miyamoto Y [2]
  • O Donoghue A [2]
  • Saxena A [2]
  • Sello JK [2]
  • Southworth DR [2]
  • Suelzen H [2]
  • Tse E [2]
  • Yan NL [2]
  • Yoo E [2]
  • Zhu J [2]
  • Benova V [1]
  • Sulzen H [1]

Author by ORCID

  • O'donoghue AJ [6]
  • Fajtova P [5]
  • Zhang H [3]
  • Zhao J [3]
  • Boura E [3]
  • Silhan J [3]
  • Yoo E [2]
  • Sello JK [2]
  • Southworth DR [2]
  • Gu X [2]
  • Gestwicki JE [2]
  • Zhu J [2]
  • Bogyo M [2]
  • Fei F [2]
  • Sulzen H [1]

Journal

  • TO BE PUBLISHED [4]
  • J MED CHEM [2]
  • NAT COMMUN [2]
  • BIORXIV [1]
  • MOLECULES [1]

Software

  • CRYOSPARC [6]
  • UCSF CHIMERAX [1]

Microscope

  • TFS KRIOS [4]
  • FEI TECNAI 12 [3]
  • FEI TITAN KRIOS [2]

Electron Source

  • FIELD EMISSION GUN [8]
  • OTHER [1]

Film or detector model

  • GATAN K3 6K X 4K [4]
  • FEI FALCON IV 4K X 4K [3]
  • GATAN K3 BIOQUANTUM 6K X 4K [2]

External links

  • AlphaFold DB [9]
  • PDB [9]
  • PDBe-Kb [9]
  • Pfam [9]
  • UniProt [9]
  • Gene Ontology [8]
  • InterPro [6]
  • Complex Portal [2]
  • DrugBank [2]
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EMD-54027
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3D View
CryoEM structure of human 20S proteasome in complex with proteasome inhibitor CP-17
CryoEM
Release date: June 24, 2026
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 9rkz
Q-score: 0.674

Benova V, Suelzen H, Boura E, Silhan J, Fajtova P

To Be Published

EMD-73509
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3D View
Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor.
CryoEM
Release date: April 15, 2026
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9yuy
Q-score: 0.61

Gu X, Fajtova P, Yan NL, Saxena A, Fei F, Zhu J, Tse E, Melo A, Yoo E, Buchwald NH, Southworth DR, Bogyo M, Derisi JL, Gestwicki JE, O'Donoghue AJ, Sello JK

J Med Chem (2026) 69 pp. 8897-8914 [ Pubmed: 41921688 DOI: doi:10.1021/acs.jmedchem.5c03223 ]

EMD-73510
Download Map
3D View
Structure of the human 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor.
CryoEM
Release date: April 15, 2026
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 9yuz
Q-score: 0.641

Gu X, Fajtova P, Yan NL, Saxena A, Fei F, Zhu J, Tse E, Melo A, Yoo E, Buchwald NH, Southworth DR, Bogyo M, Derisi JL, Gestwicki JE, O'Donoghue AJ, Sello JK

J Med Chem (2026) 69 pp. 8897-8914 [ Pubmed: 41921688 DOI: doi:10.1021/acs.jmedchem.5c03223 ]

EMD-72394
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3D View
Structure of Plasmodium falciparum 20S proteasome with bound J80
CryoEM
Release date: Oct. 29, 2025
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9y0k
Q-score: 0.539

Zhang H, Zhao J, Fajtova P, O'Donoghue AJ

To Be Published

EMD-72395
Download Map
3D View
Incorrectly assembled half-Pf20S
CryoEM
Release date: Oct. 29, 2025
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9y0l
Q-score: 0.47

Zhang H, Zhao J, Fajtova P, O'Donoghue AJ

To Be Published

EMD-72400
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3D View
The structure of the Plasmodium falciparum 20S proteasome
CryoEM
Release date: Oct. 8, 2025
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9y1o
Q-score: 0.515

Zhang H, Zhao J, Fajtova P, O'Donoghue AJ

To Be Published

EMD-52296
Download Map
3D View
CryoEM structure of human 20S proteasome in complex with proteasome inhibitor Salinosporamid A
CryoEM
Release date: March 5, 2025
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 9hmn
Q-score: 0.747

Sulzen H, Fajtova P, O'Donoghue AJ, Silhan J, Boura E

Molecules (2025) 30 [ Pubmed: 40142161 DOI: doi:10.3390/molecules30061386 ]

EMD-17337
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3D View
CryoEM structure of 20S Trichomonas vaginalis proteasome in complex with proteasome inhibitor CP-17
CryoEM
Release date: May 22, 2024
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8p0t
Q-score: 0.617

Silhan J, Fajtova P, Bartosova J, Hurysz BM, Almaliti J, Miyamoto Y, Eckmann L, Gerwick WH, O'Donoghue AJ, Boura E

Nat Commun (2024) 15 pp. 8621-8621 [ DOI: doi:10.1038/s41467-024-53022-w Pubmed: 39366995 ]

EMD-16901
Download Map
3D View
CryoEM structure of 20S Trichomonas vaginalis proteasome in complex with proteasome inhibitor Salinosporamid A
CryoEM
Release date: April 10, 2024
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8oix
Q-score: 0.581

Silhan J, Fajtova P, Bartosova J, Hurysz BM, Almaliti J, Miyamoto Y, Eckmann L, Gerwick WH, O'Donoghue AJ, Boura E

Nat Commun (2024) 15 pp. 8621-8621 [ DOI: doi:10.1038/s41467-024-53022-w Pubmed: 39366995 ]

Sort by: Download
Showing 1 - 9 of 9. Page 1 of 1
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [9]

Current status

  • REL [9]

Sample type

  • Protein [9]
  • Complex [8]
  • Ligand [7]
  • Cellular component [1]

Organism

  • Plasmodium falciparum [3]
  • Homo sapiens [3]
  • Trichomonas vaginalis [2]
  • Plasmodium falciparum [1]

EM Method

  • Single-particle [9]

Resolution

  • ≥ 2Å and < 3Å [6]
  • ≥ 3Å and < 4Å [3]

Model molecular weight

  • 250-500 kDa [1]
  • 500-1000 kDa [8]

Release Date

  • 2026 [3]
  • 2025 [4]
  • 2024 [2]

Author by name

  • Fajtova P [9]
  • O Donoghue Aj [8]
  • Boura E [4]
  • Silhan J [4]
  • Zhang H [3]
  • Zhao J [3]
  • Almaliti J [2]
  • Bartosova J [2]
  • Bogyo M [2]
  • Buchwald NH [2]
  • Derisi JL [2]
  • Eckmann L [2]
  • Fei F [2]
  • Gerwick WH [2]
  • Gestwicki JE [2]
  • Gu X [2]
  • Hurysz BM [2]
  • Melo A [2]
  • Miyamoto Y [2]
  • O Donoghue A [2]
  • Saxena A [2]
  • Sello JK [2]
  • Southworth DR [2]
  • Suelzen H [2]
  • Tse E [2]
  • Yan NL [2]
  • Yoo E [2]
  • Zhu J [2]
  • Benova V [1]
  • Sulzen H [1]

Author by ORCID

  • O'donoghue AJ [6]
  • Fajtova P [5]
  • Zhang H [3]
  • Zhao J [3]
  • Boura E [3]
  • Silhan J [3]
  • Yoo E [2]
  • Sello JK [2]
  • Southworth DR [2]
  • Gu X [2]
  • Gestwicki JE [2]
  • Zhu J [2]
  • Bogyo M [2]
  • Fei F [2]
  • Sulzen H [1]

Journal

  • TO BE PUBLISHED [4]
  • J MED CHEM [2]
  • NAT COMMUN [2]
  • BIORXIV [1]
  • MOLECULES [1]

Software

  • CRYOSPARC [6]
  • UCSF CHIMERAX [1]

Microscope

  • TFS KRIOS [4]
  • FEI TECNAI 12 [3]
  • FEI TITAN KRIOS [2]

Electron Source

  • FIELD EMISSION GUN [8]
  • OTHER [1]

Film or detector model

  • GATAN K3 6K X 4K [4]
  • FEI FALCON IV 4K X 4K [3]
  • GATAN K3 BIOQUANTUM 6K X 4K [2]

External links

  • AlphaFold DB [9]
  • PDB [9]
  • PDBe-Kb [9]
  • Pfam [9]
  • UniProt [9]
  • Gene Ontology [8]
  • InterPro [6]
  • Complex Portal [2]
  • DrugBank [2]