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grant_code:"R00HL143037"

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Current Database

  • EMDB [16]

Current status

  • REL [16]

Sample type

  • Complex [16]
  • Ligand [16]
  • Protein [16]

Organism

  • Homo sapiens [16]

EM Method

  • Single-particle [16]

Resolution

  • ≥ 2Å and < 3Å [1]
  • ≥ 3Å and < 4Å [12]
  • ≥ 4Å and < 5Å [3]

Model molecular weight

  • 100-250 kDa [3]
  • 250-500 kDa [6]
  • 500-1000 kDa [6]
  • 1-2 MDa [1]

Release Date

  • 2026 [1]
  • 2025 [4]
  • 2024 [9]
  • 2023 [2]

Author by name

  • Sun J [16]
  • Zhu H [11]
  • Hixson P [7]
  • Jiang M [6]
  • Cui C [5]
  • Kermani A [5]
  • Ma W [5]
  • Alessi DR [4]
  • Chittori S [4]
  • Cui J [4]
  • Delemotte L [4]
  • Du S [4]
  • Kermani AA [4]
  • Pipatpolkai T [4]
  • Prescott A [4]
  • Shi J [4]
  • Tan YZ [4]
  • Tonelli F [4]
  • Turk M [4]
  • Zhao L [4]
  • Hwang SH [2]
  • Miller D [2]
  • Mukhopadhyay S [2]
  • Palicharla VR [2]

Author by ORCID

  • Sun J [15]
  • Ma W [5]
  • Tan YZ [4]
  • Turk M [4]
  • Prescott A [4]
  • Delemotte L [4]
  • Alessi DR [4]
  • Tonelli F [4]
  • Zhu H [4]
  • Cui J [4]
  • Du S [4]
  • Chittori S [4]
  • Zhao L [4]
  • Hixson P [2]
  • Mukhopadhyay S [2]

Journal

  • CELL RES [6]
  • CELL DISCOV [5]
  • SCIENCE [4]
  • BIORXIV [1]
  • TO BE PUBLISHED [1]

Software

  • CRYOSPARC [13]
  • GCTF [1]
  • RELION [1]

Microscope

  • FEI TITAN KRIOS [11]
  • TFS KRIOS [5]

Electron Source

  • FIELD EMISSION GUN [16]

Film or detector model

  • GATAN K3 6K X 4K [11]
  • GATAN K3 BIOCONTINUUM 6K X 4K [4]
  • GATAN K3 BIOQUANTUM 6K X 4K [1]

External links

  • ChEBI [16]
  • DrugBank [16]
  • PDB [16]
  • PDBe-Kb [16]
  • UniProt [16]
  • AlphaFold DB [14]
  • Pfam [14]
  • Gene Ontology [13]
  • InterPro [13]
  • ChEMBL [11]
  • Complex Portal [4]
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Showing 1 - 10 of 16. Page 1 of 2
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EMD-76332
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structure of human KCNQ1-CaM-PIP2 intermediate state
CryoEM
Release date: May 6, 2026
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 12dk
Q-score: 0.442

Cui C, Kermani A, Sun J

To Be Published

EMD-64997
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3D View
structure of human KCNQ1-KCNE1-CaM complex
CryoEM
Release date: Aug. 20, 2025
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9vec
Q-score: 0.56

Cui C, Zhao L, Kermani AA, Du S, Pipatpolkai T, Jiang M, Chittori S, Tan YZ, Shi J, Delemotte L, Cui J, Sun J

Cell Res (2025) 35 pp. 876-886 [ Pubmed: 40745202 DOI: doi:10.1038/s41422-025-01152-1 ]

EMD-65008
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structure of human KCNQ1-KCNE1-CaM complex with PIP2
CryoEM
Release date: Aug. 20, 2025
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 9vei
Q-score: 0.394

Cui C, Zhao L, Kermani AA, Du S, Pipatpolkai T, Jiang M, Chittori S, Tan YZ, Shi J, Delemotte L, Cui J, Sun J

Cell Res (2025) 35 pp. 876-886 [ Pubmed: 40745202 DOI: doi:10.1038/s41422-025-01152-1 ]

EMD-65013
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structure of human KCNQ1-CaM-PIP2 complex with bent conformation
CryoEM
Release date: Aug. 20, 2025
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9ven
Q-score: 0.47

Cui C, Zhao L, Kermani AA, Du S, Pipatpolkai T, Jiang M, Chittori S, Tan YZ, Shi J, Delemotte L, Cui J, Sun J

Cell Res (2025) 35 pp. 876-886 [ Pubmed: 40745202 DOI: doi:10.1038/s41422-025-01152-1 ]

EMD-65014
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structure of human KCNQ1-CaM-PIP2 complex with straight conformation
CryoEM
Release date: Aug. 20, 2025
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 9veo
Q-score: 0.418

Cui C, Zhao L, Kermani AA, Du S, Pipatpolkai T, Jiang M, Chittori S, Tan YZ, Shi J, Delemotte L, Cui J, Sun J

Cell Res (2025) 35 pp. 876-886 [ Pubmed: 40745202 DOI: doi:10.1038/s41422-025-01152-1 ]

EMD-41982
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Cryo-EM structure of LRRK2 bound to type I inhibitor GNE-7915
CryoEM
Release date: Jan. 31, 2024
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8u7h
Q-score: 0.442

Zhu H, Hixson P, Ma W, Sun J

Cell Discov (2024) 10 pp. 10-10 [ Pubmed: 38263358 DOI: doi:10.1038/s41421-023-00639-8 ]

EMD-41985
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Cryo-EM structure of LRRK2 bound to type II inhibitor GZD824
CryoEM
Release date: Jan. 31, 2024
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8u7l
Q-score: 0.345

Zhu H, Hixson P, Ma W, Sun J

Cell Discov (2024) 10 pp. 10-10 [ Pubmed: 38263358 DOI: doi:10.1038/s41421-023-00639-8 ]

EMD-42019
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Cryo-EM structure of LRRK2 bound to type II inhibitor ponatinib
CryoEM
Release date: Jan. 31, 2024
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8u8a
Q-score: 0.395

Zhu H, Hixson P, Ma W, Sun J

Cell Discov (2024) 10 pp. 10-10 [ Pubmed: 38263358 DOI: doi:10.1038/s41421-023-00639-8 ]

EMD-42020
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Cryo-EM structure of LRRK2 bound to type II inhibitor rebastinib
CryoEM
Release date: Jan. 31, 2024
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8u8b
Q-score: 0.312

Zhu H, Hixson P, Ma W, Sun J

Cell Discov (2024) 10 pp. 10-10 [ Pubmed: 38263358 DOI: doi:10.1038/s41421-023-00639-8 ]

EMD-29340
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Cryo-EM structure of LRRK2 bound to type I inhibitor LRRK2-IN-1
CryoEM
Release date: Jan. 17, 2024
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8fo7
Q-score: 0.459

Zhu H, Hixson P, Ma W, Sun J

Cell Discov (2024) 10 pp. 10-10 [ Pubmed: 38263358 DOI: doi:10.1038/s41421-023-00639-8 ]

Sort by: Download
Showing 1 - 10 of 16. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [16]

Current status

  • REL [16]

Sample type

  • Complex [16]
  • Ligand [16]
  • Protein [16]

Organism

  • Homo sapiens [16]

EM Method

  • Single-particle [16]

Resolution

  • ≥ 2Å and < 3Å [1]
  • ≥ 3Å and < 4Å [12]
  • ≥ 4Å and < 5Å [3]

Model molecular weight

  • 100-250 kDa [3]
  • 250-500 kDa [6]
  • 500-1000 kDa [6]
  • 1-2 MDa [1]

Release Date

  • 2026 [1]
  • 2025 [4]
  • 2024 [9]
  • 2023 [2]

Author by name

  • Sun J [16]
  • Zhu H [11]
  • Hixson P [7]
  • Jiang M [6]
  • Cui C [5]
  • Kermani A [5]
  • Ma W [5]
  • Alessi DR [4]
  • Chittori S [4]
  • Cui J [4]
  • Delemotte L [4]
  • Du S [4]
  • Kermani AA [4]
  • Pipatpolkai T [4]
  • Prescott A [4]
  • Shi J [4]
  • Tan YZ [4]
  • Tonelli F [4]
  • Turk M [4]
  • Zhao L [4]
  • Hwang SH [2]
  • Miller D [2]
  • Mukhopadhyay S [2]
  • Palicharla VR [2]

Author by ORCID

  • Sun J [15]
  • Ma W [5]
  • Tan YZ [4]
  • Turk M [4]
  • Prescott A [4]
  • Delemotte L [4]
  • Alessi DR [4]
  • Tonelli F [4]
  • Zhu H [4]
  • Cui J [4]
  • Du S [4]
  • Chittori S [4]
  • Zhao L [4]
  • Hixson P [2]
  • Mukhopadhyay S [2]

Journal

  • CELL RES [6]
  • CELL DISCOV [5]
  • SCIENCE [4]
  • BIORXIV [1]
  • TO BE PUBLISHED [1]

Software

  • CRYOSPARC [13]
  • GCTF [1]
  • RELION [1]

Microscope

  • FEI TITAN KRIOS [11]
  • TFS KRIOS [5]

Electron Source

  • FIELD EMISSION GUN [16]

Film or detector model

  • GATAN K3 6K X 4K [11]
  • GATAN K3 BIOCONTINUUM 6K X 4K [4]
  • GATAN K3 BIOQUANTUM 6K X 4K [1]

External links

  • ChEBI [16]
  • DrugBank [16]
  • PDB [16]
  • PDBe-Kb [16]
  • UniProt [16]
  • AlphaFold DB [14]
  • Pfam [14]
  • Gene Ontology [13]
  • InterPro [13]
  • ChEMBL [11]
  • Complex Portal [4]