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author:"Matyskiela M"

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EMD-72086
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Cryo-EM structure of ternary complex BCL6-CRBN-DDB1 with BCL6-760 LDD, local refined
Release date: Oct. 15, 2025
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 9q03
Q-score: 0.371

Shunatona HP, Holmberg Douglas N, Rhodes J, Thomas W, Da Silva D, Gamez J, Groza M, Christoforou A, Zhu J, Johnson S, Dodd D, Huang D, Griffin J, Miseo G, Whitefield B, Weiss D, Rader J, Kuzu E, Leisten J, Del Rosario J, Shi L, Matyskiela M, Chamberlain PP, Belmont P, Alexander M, Zapf CW, Groocock L, Mortensen DS

J Med Chem (2025) 68 pp. 21502-21519 [ DOI: doi:10.1021/acs.jmedchem.5c01645 Pubmed: 41055242 ]

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Filter By

Current Database

  • EMDB [1]

Current status

  • REL [1]

Sample type

  • Complex [1]
  • Ligand [1]
  • Protein [1]

Organism

  • Homo sapiens [1]

EM Method

  • Single-particle [1]

Resolution

  • ≥ 3Å and < 4Å [1]

Model molecular weight

  • 50-100 kDa [1]

Release Date

  • 2025 [1]

Author by name

  • Alexander M [1]
  • Belmont P [1]
  • Chamberlain PP [1]
  • Christoforou A [1]
  • Da Silva D [1]
  • Del Rosario J [1]
  • Dodd D [1]
  • Fang W [1]
  • Gamez J [1]
  • Griffin J [1]
  • Groocock L [1]
  • Groza M [1]
  • Holmberg Douglas N [1]
  • Huang D [1]
  • Johnson S [1]
  • Kuzu E [1]
  • Leisten J [1]
  • Matyskiela M [1]
  • Miseo G [1]
  • Mortensen DS [1]
  • Pagarigan B [1]
  • Rader J [1]
  • Rhodes J [1]
  • Shi L [1]
  • Shunatona HP [1]
  • Thomas W [1]
  • Weiss D [1]
  • Whitefield B [1]
  • Zapf CW [1]
  • Zhu J [1]

Author by ORCID

  • Zhu J [1]
  • Shunatona HP [1]
  • Chamberlain PP [1]
  • Mortensen DS [1]
  • Shi L [1]
  • Holmberg Douglas N [1]

Journal

  • J MED CHEM [1]

Software

  • CRYOSPARC [1]

Microscope

  • TFS KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [1]

Film or detector model

  • TFS FALCON 4I 4K X 4K [1]

External links

  • AlphaFold DB [1]
  • ChEBI [1]
  • ChEMBL [1]
  • DrugBank [1]
  • Gene Ontology [1]
  • PDB [1]
  • PDBe-Kb [1]
  • Pfam [1]
  • UniProt [1]