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author:"Lehmann EF"

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Current Database

  • EMDB [12]

Current status

  • REL [12]

Sample type

  • Complex [12]
  • Protein [12]
  • Ligand [3]

Organism

  • Homo sapiens [8]
  • Synthetic construct [5]
  • Mus musculus [4]

EM Method

  • Single-particle [12]

Resolution

  • ≥ 2Å and < 3Å [1]
  • ≥ 3Å and < 4Å [7]
  • ≥ 4Å and < 5Å [3]
  • ≥ 6Å and < 8Å [1]

Model molecular weight

  • 50-100 kDa [3]
  • 250-500 kDa [2]
  • 500-1000 kDa [5]

Release Date

  • 2026 [4]
  • 2024 [5]
  • 2023 [3]

Author by name

  • Dutzler R [12]
  • Lehmann EF [12]
  • Rutz S [9]
  • Barone A [5]
  • Campos-xavier B [5]
  • Garavelli L [5]
  • Innes AM [5]
  • Kellenberger S [5]
  • Peng Z [5]
  • Peter V [5]
  • Quinodoz M [5]
  • Rivolta C [5]
  • Superti-furga A [5]
  • Unger S [5]
  • Deneka D [4]
  • Innes MA [4]
  • Stierli F [4]
  • Altermatt P [3]
  • Drozdzyk K [3]
  • Durrenberger F [3]
  • Langini C [3]
  • Liziczai M [3]
  • Manatschal C [3]
  • Manolova V [3]
  • Sundstrom H [3]
  • Innes M [1]

Author by ORCID

  • Dutzler R [12]
  • Lehmann EF [12]
  • Barone A [5]
  • Peter V [5]
  • Innes AM [5]
  • Rivolta C [5]
  • Superti-furga A [5]
  • Campos-xavier B [5]
  • Quinodoz M [5]
  • Kellenberger S [5]
  • Rutz S [4]
  • Drozdzyk K [3]
  • Durrenberger F [3]
  • Manatschal C [3]
  • Liziczai M [3]

Journal

  • EMBO J [5]
  • NAT COMMUN [4]
  • ELIFE [3]

Software

  • CRYOSPARC [4]

Microscope

  • TFS KRIOS [8]
  • FEI TITAN KRIOS [3]
  • TFS GLACIOS [1]

Electron Source

  • FIELD EMISSION GUN [12]

Film or detector model

  • GATAN K3 BIOQUANTUM 6K X 4K [11]
  • TFS FALCON 4I 4K X 4K [1]

External links

  • AlphaFold DB [12]
  • PDBe-Kb [12]
  • UniProt [12]
  • PDB [10]
  • Pfam [10]
  • InterPro [6]
  • Gene Ontology [5]
  • ChEMBL [3]
  • Complex Portal [3]
  • ChEBI [2]
  • DrugBank [1]
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Showing 1 - 10 of 12. Page 1 of 2
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EMD-55589
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3D View
Structure of mouse full-length LRRC8D
CryoEM
Release date: Sept. 2, 2026
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 9t5m
Q-score: 0.35
Similar entry percentile: 7%

Lehmann EF, Stierli F, Rutz S, Deneka D, Dutzler R

Nat Commun (2026) 17 [ Pubmed: 42754598 DOI: doi:10.1038/s41467-026-77508-x ]

EMD-55590
Download Map
3D View
Structure of heteromeric mouse LRRC8A/D Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1, Conformation 1
CryoEM
Release date: Sept. 2, 2026
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 9t5n
Q-score: 0.313
Similar entry percentile: 4%

Lehmann EF, Stierli F, Rutz S, Deneka D, Dutzler R

Nat Commun (2026) 17 [ Pubmed: 42754598 DOI: doi:10.1038/s41467-026-77508-x ]

EMD-55591
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3D View
Structure of heteromeric mouse LRRC8A/D Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1, Conformation 2
CryoEM
Release date: Sept. 2, 2026
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 9t5o
Q-score: 0.249
Similar entry percentile: 2%

Lehmann EF, Stierli F, Rutz S, Deneka D, Dutzler R

Nat Commun (2026) 17 [ Pubmed: 42754598 DOI: doi:10.1038/s41467-026-77508-x ]

EMD-55592
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3D View
Structure of heteromeric mouse LRRC8A/D Volume-Regulated Anion Channel in complex with synthetic nanobody Sb4
CryoEM
Release date: Sept. 2, 2026
Resolution: 3.97 Å
EM Method: Single-particle
Fitted PDBs: 9t5p
Q-score: 0.302
Similar entry percentile: 22%

Lehmann EF, Stierli F, Rutz S, Deneka D, Dutzler R

Nat Commun (2026) 17 [ Pubmed: 42754598 DOI: doi:10.1038/s41467-026-77508-x ]

EMD-19495
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3D View
Structure of a homomeric human LRRC8C Volume-Regulated Anion Channel
CryoEM
Release date: Nov. 13, 2024
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 8rts
Q-score: 0.225
Similar entry percentile: 5%

Quinodoz M, Rutz S, Peter V, Garavelli L, Innes AM, Lehmann EF, Kellenberger S, Peng Z, Barone A, Campos-Xavier B, Unger S, Rivolta C, Dutzler R, Superti-Furga A

EMBO J (2025) 44 pp. 413-436 [ Pubmed: 39623139 DOI: doi:10.1038/s44318-024-00322-y ]

EMD-50072
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3D View
Structure of the extracellular subdomain of a homomeric LRRC8C truncation disease mutant
CryoEM
Release date: Nov. 13, 2024
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 9ezc
Q-score: 0.297
Similar entry percentile: 7%

Quinodoz M, Rutz S, Peter V, Garavelli L, Innes AM, Lehmann EF, Kellenberger S, Peng Z, Barone A, Campos-Xavier B, Unger S, Rivolta C, Dutzler R, Superti-Furga A

EMBO J (2025) 44 pp. 413-436 [ Pubmed: 39623139 DOI: doi:10.1038/s44318-024-00322-y ]

EMD-50073
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3D View
Cryo-EM structure of a homomeric LRRC8C truncation disease mutant, with C1 symmetry
CryoEM
Release date: Nov. 13, 2024
Resolution: 7.32 Å
EM Method: Single-particle

Quinodoz M, Rutz S, Peter V, Garavelli L, Innes AM, Lehmann EF, Kellenberger S, Peng Z, Barone A, Campos-Xavier B, Unger S, Rivolta C, Dutzler R, Superti-Furga A

EMBO J (2025) 44 pp. 413-436 [ Pubmed: 39623139 DOI: doi:10.1038/s44318-024-00322-y ]

EMD-50074
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3D View
Cryo-EM structure of a homomeric LRRC8C truncation disease mutant, with C7 symmetry
CryoEM
Release date: Nov. 13, 2024
Resolution: 4.95 Å
EM Method: Single-particle

Quinodoz M, Rutz S, Peter V, Garavelli L, Innes AM, Lehmann EF, Kellenberger S, Peng Z, Barone A, Campos-Xavier B, Unger S, Rivolta C, Dutzler R, Superti-Furga A

EMBO J (2025) 44 pp. 413-436 [ Pubmed: 39623139 DOI: doi:10.1038/s44318-024-00322-y ]

EMD-50123
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3D View
Structure of a homomeric LRRC8C point mutation disease mutant
CryoEM
Release date: Nov. 13, 2024
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 9f16
Q-score: 0.251
Similar entry percentile: 31%

Quinodoz M, Rutz S, Peter V, Garavelli L, Innes AM, Lehmann EF, Kellenberger S, Peng Z, Barone A, Campos-Xavier B, Unger S, Rivolta C, Dutzler R, Superti-Furga A

EMBO J (2025) 44 pp. 413-436 [ Pubmed: 39623139 DOI: doi:10.1038/s44318-024-00322-y ]

EMD-16345
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3D View
Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy3 in occluded conformation
CryoEM
Release date: March 22, 2023
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8bzy

Lehmann EF, Liziczai M, Drozdzyk K, Altermatt P, Langini C, Manolova V, Sundstrom H, Durrenberger F, Dutzler R, Manatschal C

eLife (2023) 12 [ Pubmed: 36943194 DOI: doi:10.7554/eLife.83053 ]

Sort by: Download
Showing 1 - 10 of 12. Page 1 of 2
Display:
Statistics
×

Download


Preview 10 entries View All Download file

Filter By

Current Database

  • EMDB [12]

Current status

  • REL [12]

Sample type

  • Complex [12]
  • Protein [12]
  • Ligand [3]

Organism

  • Homo sapiens [8]
  • Synthetic construct [5]
  • Mus musculus [4]

EM Method

  • Single-particle [12]

Resolution

  • ≥ 2Å and < 3Å [1]
  • ≥ 3Å and < 4Å [7]
  • ≥ 4Å and < 5Å [3]
  • ≥ 6Å and < 8Å [1]

Model molecular weight

  • 50-100 kDa [3]
  • 250-500 kDa [2]
  • 500-1000 kDa [5]

Release Date

  • 2026 [4]
  • 2024 [5]
  • 2023 [3]

Author by name

  • Dutzler R [12]
  • Lehmann EF [12]
  • Rutz S [9]
  • Barone A [5]
  • Campos-xavier B [5]
  • Garavelli L [5]
  • Innes AM [5]
  • Kellenberger S [5]
  • Peng Z [5]
  • Peter V [5]
  • Quinodoz M [5]
  • Rivolta C [5]
  • Superti-furga A [5]
  • Unger S [5]
  • Deneka D [4]
  • Innes MA [4]
  • Stierli F [4]
  • Altermatt P [3]
  • Drozdzyk K [3]
  • Durrenberger F [3]
  • Langini C [3]
  • Liziczai M [3]
  • Manatschal C [3]
  • Manolova V [3]
  • Sundstrom H [3]
  • Innes M [1]

Author by ORCID

  • Dutzler R [12]
  • Lehmann EF [12]
  • Barone A [5]
  • Peter V [5]
  • Innes AM [5]
  • Rivolta C [5]
  • Superti-furga A [5]
  • Campos-xavier B [5]
  • Quinodoz M [5]
  • Kellenberger S [5]
  • Rutz S [4]
  • Drozdzyk K [3]
  • Durrenberger F [3]
  • Manatschal C [3]
  • Liziczai M [3]

Journal

  • EMBO J [5]
  • NAT COMMUN [4]
  • ELIFE [3]

Software

  • CRYOSPARC [4]

Microscope

  • TFS KRIOS [8]
  • FEI TITAN KRIOS [3]
  • TFS GLACIOS [1]

Electron Source

  • FIELD EMISSION GUN [12]

Film or detector model

  • GATAN K3 BIOQUANTUM 6K X 4K [11]
  • TFS FALCON 4I 4K X 4K [1]

External links

  • AlphaFold DB [12]
  • PDBe-Kb [12]
  • UniProt [12]
  • PDB [10]
  • Pfam [10]
  • InterPro [6]
  • Gene Ontology [5]
  • ChEMBL [3]
  • Complex Portal [3]
  • ChEBI [2]
  • DrugBank [1]