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author:"Leffler A"

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Current Database

  • EMDB [24]

Current status

  • REL [24]

Sample type

  • Complex [24]
  • Protein [24]
  • Ligand [22]

Organism

  • Rattus norvegicus [19]
  • Homo sapiens [5]
  • Oryctolagus cuniculus [2]

EM Method

  • Single-particle [24]

Resolution

  • ≥ 2Å and < 3Å [11]
  • ≥ 3Å and < 4Å [11]
  • ≥ 4Å and < 5Å [2]

Model molecular weight

  • 250-500 kDa [24]

Release Date

  • 2026 [6]
  • 2025 [6]
  • 2024 [4]
  • 2023 [4]
  • 2022 [4]

Author by name

  • Leffler A [24]
  • Moiseenkova-bell VY [24]
  • Pumroy RA [24]
  • Fricke TC [19]
  • Rocereta JA [16]
  • Herzog C [15]
  • Moiseenkova-bell V [15]
  • De Jesus-Perez Jj [9]
  • Echtermeyer FG [9]
  • Haug FM [8]
  • Protopopova AD [8]
  • Hill K [6]
  • Sturhahn T [6]
  • Meyer MJA [5]
  • Oprita G [5]
  • Pumroy RP [5]
  • Bernardes GJL [4]
  • Dimek F [4]
  • Fluck EC [4]
  • Fricke T [4]
  • Gallo PN [4]
  • Hage A [4]
  • Howard RJ [4]
  • Koh A [4]
  • Kotecha A [4]
  • Lange IU [4]
  • Lee BH [4]
  • Lindahl E [4]
  • Nguyen PT [4]
  • Pantke S [4]
  • Rohacs T [4]
  • Sousa BB [4]
  • Sridhar A [4]
  • Yarov-yarovoy V [4]
  • De La Roche J [4]
  • Leipe A [1]
  • Schaefer M [1]

Author by ORCID

  • Leffler A [9]
  • Moiseenkova-bell VY [5]
  • Rocereta JA [5]
  • Pumroy RA [5]
  • Hill K [5]
  • Meyer MJA [5]
  • Oprita G [5]
  • Moiseenkova-bell V [4]
  • Rohacs T [4]
  • Fricke T [4]

Journal

  • NAT COMMUN [9]
  • NAT STRUCT MOL BIOL [6]
  • EMBO J [4]
  • EMBO REP [4]
  • BR.J.PHARMACOL. [1]

Software

  • CRYOSPARC [9]
  • RELION [2]
  • CTFFIND [1]

Microscope

  • FEI TITAN KRIOS [16]
  • TFS GLACIOS [5]
  • FEI TITAN [2]
  • TFS KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [24]

Film or detector model

  • GATAN K3 6K X 4K [15]
  • FEI FALCON IV 4K X 4K [9]

External links

  • AlphaFold DB [24]
  • PDB [24]
  • PDBe-Kb [24]
  • Pfam [24]
  • UniProt [24]
  • Gene Ontology [19]
  • InterPro [18]
  • ChEBI [13]
  • ChEMBL [13]
  • DrugBank [9]
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Showing 1 - 10 of 24. Page 1 of 3
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EMD-75707
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Apo human TRPV2, wild-type
CryoEM
Release date: Sept. 2, 2026
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 11hz
Q-score: 0.49
Similar entry percentile: 67%

Fricke TC, Pumroy RA, Rocereta JA, De Jesus-Perez JJ, Oprita G, Meyer MJA, Herzog C, Echtermeyer FG, Hill K, Leffler A, Moiseenkova-Bell VY

Nat Commun (2026) 17 [ Pubmed: 42624855 DOI: doi:10.1038/s41467-026-76831-7 ]

EMD-75708
Download Map
3D View
Apo human TRPV2, S651H/T654D/D655N
CryoEM
Release date: Sept. 2, 2026
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 11ia
Q-score: 0.607
Similar entry percentile: 90%

Fricke TC, Pumroy RA, Rocereta JA, De Jesus-Perez JJ, Oprita G, Meyer MJA, Herzog C, Echtermeyer FG, Hill K, Leffler A, Moiseenkova-Bell VY

Nat Commun (2026) 17 [ Pubmed: 42624855 DOI: doi:10.1038/s41467-026-76831-7 ]

EMD-75709
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3D View
2-APB bound human TRPV2, S651H/T654D/D655N
CryoEM
Release date: Sept. 2, 2026
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 11ib
Q-score: 0.51
Similar entry percentile: 75%

Fricke TC, Pumroy RA, Rocereta JA, De Jesus-Perez JJ, Oprita G, Meyer MJA, Herzog C, Echtermeyer FG, Hill K, Leffler A, Moiseenkova-Bell VY

Nat Commun (2026) 17 [ Pubmed: 42624855 DOI: doi:10.1038/s41467-026-76831-7 ]

EMD-75711
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3D View
apo rat TRPV2, H651S/D654T/N655D
CryoEM
Release date: Sept. 2, 2026
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 11id
Q-score: 0.569
Similar entry percentile: 85%

Fricke TC, Pumroy RA, Rocereta JA, De Jesus-Perez JJ, Oprita G, Meyer MJA, Herzog C, Echtermeyer FG, Hill K, Leffler A, Moiseenkova-Bell VY

Nat Commun (2026) 17 [ Pubmed: 42624855 DOI: doi:10.1038/s41467-026-76831-7 ]

EMD-75712
Download Map
3D View
2-APB bound rat TRPV2, H651S/D654T/N655D
CryoEM
Release date: Sept. 2, 2026
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 11ie
Q-score: 0.553
Similar entry percentile: 83%

Fricke TC, Pumroy RA, Rocereta JA, De Jesus-Perez JJ, Oprita G, Meyer MJA, Herzog C, Echtermeyer FG, Hill K, Leffler A, Moiseenkova-Bell VY

Nat Commun (2026) 17 [ Pubmed: 42624855 DOI: doi:10.1038/s41467-026-76831-7 ]

EMD-48325
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Rat TRPV2 bound to AV2-1 agonist
CryoEM
Release date: April 15, 2026
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 9mkf
Q-score: 0.559
Similar entry percentile: 76%

Leipe A, Rocereta JA, Pumroy RA, Leffler A, Schaefer M, Moiseenkova-Bell V, Hill K

Br.J.Pharmacol. (2026) 183 pp. 3538-3557 [ DOI: doi:10.1111/bph.70413 Pubmed: 41913383 ]

EMD-44156
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3D View
Rat TRPV2 WT bound to probenecid
CryoEM
Release date: Feb. 26, 2025
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9b3u
Q-score: 0.61
Similar entry percentile: 75%

Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V

Nat Struct Mol Biol (2025) 32 pp. 1019-1029 [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]

EMD-44157
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Rat TRPV2 WT in the presence of probenecid and 2-APB
CryoEM
Release date: Feb. 26, 2025
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 9b3v
Q-score: 0.381
Similar entry percentile: 67%

Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V

Nat Struct Mol Biol (2025) 32 pp. 1019-1029 [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]

EMD-44158
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3D View
Rat TRPV2 E724A/D725A Apo
CryoEM
Release date: Feb. 26, 2025
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 9b3w
Q-score: 0.622
Similar entry percentile: 85%

Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V

Nat Struct Mol Biol (2025) 32 pp. 1019-1029 [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]

EMD-44159
Download Map
3D View
Rat TRPV2 E724A/D725A bound to 2-APB
CryoEM
Release date: Feb. 26, 2025
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9b3x
Q-score: 0.502
Similar entry percentile: 65%

Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V

Nat Struct Mol Biol (2025) 32 pp. 1019-1029 [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]

Sort by: Download
Showing 1 - 10 of 24. Page 1 of 3
Display:
Statistics
×

Download


Preview 10 entries View All Download file

Filter By

Current Database

  • EMDB [24]

Current status

  • REL [24]

Sample type

  • Complex [24]
  • Protein [24]
  • Ligand [22]

Organism

  • Rattus norvegicus [19]
  • Homo sapiens [5]
  • Oryctolagus cuniculus [2]

EM Method

  • Single-particle [24]

Resolution

  • ≥ 2Å and < 3Å [11]
  • ≥ 3Å and < 4Å [11]
  • ≥ 4Å and < 5Å [2]

Model molecular weight

  • 250-500 kDa [24]

Release Date

  • 2026 [6]
  • 2025 [6]
  • 2024 [4]
  • 2023 [4]
  • 2022 [4]

Author by name

  • Leffler A [24]
  • Moiseenkova-bell VY [24]
  • Pumroy RA [24]
  • Fricke TC [19]
  • Rocereta JA [16]
  • Herzog C [15]
  • Moiseenkova-bell V [15]
  • De Jesus-Perez Jj [9]
  • Echtermeyer FG [9]
  • Haug FM [8]
  • Protopopova AD [8]
  • Hill K [6]
  • Sturhahn T [6]
  • Meyer MJA [5]
  • Oprita G [5]
  • Pumroy RP [5]
  • Bernardes GJL [4]
  • Dimek F [4]
  • Fluck EC [4]
  • Fricke T [4]
  • Gallo PN [4]
  • Hage A [4]
  • Howard RJ [4]
  • Koh A [4]
  • Kotecha A [4]
  • Lange IU [4]
  • Lee BH [4]
  • Lindahl E [4]
  • Nguyen PT [4]
  • Pantke S [4]
  • Rohacs T [4]
  • Sousa BB [4]
  • Sridhar A [4]
  • Yarov-yarovoy V [4]
  • De La Roche J [4]
  • Leipe A [1]
  • Schaefer M [1]

Author by ORCID

  • Leffler A [9]
  • Moiseenkova-bell VY [5]
  • Rocereta JA [5]
  • Pumroy RA [5]
  • Hill K [5]
  • Meyer MJA [5]
  • Oprita G [5]
  • Moiseenkova-bell V [4]
  • Rohacs T [4]
  • Fricke T [4]

Journal

  • NAT COMMUN [9]
  • NAT STRUCT MOL BIOL [6]
  • EMBO J [4]
  • EMBO REP [4]
  • BR.J.PHARMACOL. [1]

Software

  • CRYOSPARC [9]
  • RELION [2]
  • CTFFIND [1]

Microscope

  • FEI TITAN KRIOS [16]
  • TFS GLACIOS [5]
  • FEI TITAN [2]
  • TFS KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [24]

Film or detector model

  • GATAN K3 6K X 4K [15]
  • FEI FALCON IV 4K X 4K [9]

External links

  • AlphaFold DB [24]
  • PDB [24]
  • PDBe-Kb [24]
  • Pfam [24]
  • UniProt [24]
  • Gene Ontology [19]
  • InterPro [18]
  • ChEBI [13]
  • ChEMBL [13]
  • DrugBank [9]