Please visit the new BioModels platform to access the latest content. This website is no longer updated and will be retired on 31 May 2019.
BioModels Database logo

BioModels Database


MODEL1505110000 - Millard2016 - E. coli central carbon and energy metabolism


The following model is part of the non-curated branch of BioModels Database. While the syntax of the model has been verified, its semantics remains unchecked. Any annotation present in the models is not a product of BioModels' annotators. We are doing our best to incorporate this model into the curated branch as soon as possible. In the meantime, we display only limited metadata here. For further information about the model, please download the SBML file.

 |   |   |  Send feedback
Reference Publication
Publication ID: 10.1371/journal.pcbi...
Pierre Millard , Kieran Smallbone, Pedro Mendes
Metabolic regulation is sufficient for global and robust coordination of glucose uptake, catabolism, energy production and growth in Escherichia coli
MCISB, Manchester Institute of Biotechnology, University of Manchester, Manchester, United Kingdom, School of Computer Science, University of Manchester, Manchester, United Kingdom; LISBP, Universit√© de Toulouse, CNRS, INRA, INSA, Toulouse, France; Center for Quantitative Medicine and Dept. Cell Biology, UConn Health, Farmington, Connecticut, United States of America  [more]
Original Model: MODEL1505110000.origin
Submitter: Pierre Millard
Submission Date: 11 May 2015 06:07:53 UTC
Last Modification Date: 31 May 2017 10:41:43 UTC
Creation Date: 10 May 2015 22:00:37 UTC
Encoders:  Kieran Smallbone
   Pedro Mendes
   Pierre Millard
Millard2016 - E. coli central carbon and energy metabolism

This model is described in the article:

Pierre Millard , Kieran Smallbone, Pedro Mendes


The metabolism of microorganisms is regulated through two main mechanisms: changes of enzyme capacities as a consequence of gene expression modulation (“hierarchical control”) and changes of enzyme activities through metabolite-enzyme interactions. An increasing body of evidence indicates that hierarchical control is insufficient to explain metabolic behaviors, but the system-wide impact of metabolic regulation remains largely uncharacterized. To clarify its role, we developed and validated a detailed kinetic model of Escherichia coli central metabolism that links growth to environment. Metabolic control analyses confirm that the control is widely distributed across the network and highlight strong interconnections between all the pathways. Exploration of the model solution space reveals that several robust properties emerge from metabolic regulation, from the molecular level (e.g. homeostasis of total metabolite pool) to the overall cellular physiology (e.g. coordination of carbon uptake, catabolism, energy and redox production, and growth), while allowing a large degree of flexibility at most individual metabolic steps. These properties have important physiological implications for E. coli and significantly expand the self-regulating capacities of its metabolism.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.