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ATC Codes for Parasitic Organisms

This page provides a list of drugs targeted against parasitic organisms, classified using the Anatomical Therapeutic Chemical (ATC) classification system.

P01 Antiprotozoals (64)

Acridines (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL7568
P01AX05 mepacrine Intercalates into DNA; inhibits telomerase, topoisomerase, and proteins involved in multidrug resistance; 85 kDa calcium-independent phospholipase A2 antagonist; cytosolic phospholipase A2 antagonist; phospholipase C antagonist; Histamine N-methyltransferase inhibitor; substrate for Cytochrome P450 3A4 and Cytochrome P450 3A5; solute carrier family 22 member 2 inhibitor; multidrug resistance protein 1 inhibitor; affects the p53, NF-kB and AKT pathways. Acranil, Acrichine, Acriquine, Atabrine, Atebrin, Chinacrin, Erion, Italchin, Maladin, Metoquine, Palacrin, Quinacrine.

Antimony compounds (2)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL239129
P01CB01 meglumine antimonate Binds to polypeptides; inhibits DNA topoisomerase, glycolytic enzymes, and fatty acid beta-oxidation. Glucantime, Glucantim, Protostib

CHEMBL467918
P01CB02 sodium stibogluconate DNA topoisomerase 1 antagonist Lenocta, Myostibin, Pentostam, Stibanate, Stibanose, Stibatin, Stibinol, Stiboson

Arsenic compounds (6)

Structure ATC Code Generic Name Mechanism Trade Names
Not Available P01AR01 arsthinol Inhibition of glycolytic enzymes and/or protein kinases with SH- groups Belarsen
Not Available P01AR02 difetarsone May replace phosphate in several reactions causing ATP depletion Bemarsal
Not Available P01AR03 glycobiarsol Inhibition of glycolytic enzymes and/or protein kinases with SH- groups Bismuth glycoloylarsanilate, Broxolin, Dysentulin, Milibis, Viasept, Wintodon
Not Available P01AR53 glycobiarsol, combinations

CHEMBL166
P01CD01 melarsoprol High affinity for sulfhydryl groups, thus binds to enzymes with these groups, e.g. binds to and inhibits pyruvate kinase. Arsobal, Mel B, Melarsen Oxide- BAL

CHEMBL1330792
P01CD02 acetarsol May replace phosphate in several reactions causing ATP depletion Acetphenarsine, Amarsan, Amoebal, Arsaphen, Arsonine, Devegan, Disparicida, Dynarsan, Ehrlich 594, Fourneau 190, Ginarsol, Goyl, Gynoplix Theraplix, Kharophen, Kubarsol, Laryngarsol Spray, Limarsol, Malagride, Mexyl, Monargan, Oralcid, Orarsan, Osarsal, Osarsol, Osarsole, Osarsolum, Osvarsan, Osvarson, Pallicid, Paroxyl, R.V.C., Spirocid, Spirozid, Stovarsal, Stovarsol, Stovarsolan, SVC, Vagisept, Vagoflor

Artemisinin and derivatives (11)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL77
P01BE01 artemisinin Activated by the intra-parasitic haem to irreversibly decompose, generating free radicals that alkylate and oxidises proteins and lipids. The membrane of the parasite is damaged by lipid peroxidation and channel proteins inactivation. Qing Hau Sau, Qinghaosu

CHEMBL1237051
P01BE02 artemether Interacts with ferriprotoporphyrin IX; induces and is a substrate for Cytochrome P450 3A4, Cytochrome P450 2B6, Cytochrome P450 2C19; substrate for Cytochrome P450 3A5, Cytochrome P450 2C9, Cytochrome P450 2D6. Artem, Artesaph, Artenam, Larither, Paluther

CHEMBL258608
P01BE03 artesunate Artesunate endoperoxide bridge is split by heme within the infected erythrocyte, generating singlet oxygen. Parasite proteins, particularly in membranous structures, are thus alkylated, leading to parasite death. Arsumax, Falcigo, Cosunate, Malartem, Plasmotrim, Zysunate, Arinate, Saphnate, Falcinil

CHEMBL301267
P01BE04 artemotil Generation of free radicals due to an interaction with haem. Ionic scission of the peroxide group and consequent generation of carbocation at C-4 has also been suggested to account for antimalarial activity. Artecef, Arteether, Beta-Arteether, Betamotil, Rapither-AB

CHEMBL25164
P01BE05 artenimol Reacts with heme to produce free radicals. Cotecxin, Dihydroqinghaosu, Dihydroartemisinin
Not Available P01BF01 artemether and lumefantrine Coartem, Lonart, Riamet
Not Available P01BF02 artesunate and mefloquine Artequin
Not Available P01BF03 artesunate and amodiaquine Amonate, Artesun-Plus, Coarsucam, Dart, Diasunate, Larimal
Not Available P01BF04 artesunate, sulphamethopyrazine and pyrimethamine Co-arinate
Not Available P01BF05 artenimol and piperaquine Artekin, Duo-Cotecxin, P-Alaxin
Not Available P01BF06 artesunate and pyronaridine Pyramax

Benzamidines (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL55
P01CX01 pentamidine isethionate Intercalates into DNA; binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation; substrate for Cytochrome P450 2C19, Cytochrome P450 1A1, Cytochrome P450 2D6, Cytochrome P450 3A5, Cytochrome P450 4A11, Cytochrome P450 1A2, Cytochrome P450 2C8, Cytochrome P450 3A4. Diamidine, Lomidin, Lomidine, NebuPent, Pentacarinat , Pentacarinate, Pentam, Pentamina, Pneumopent

Biguanides (3)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL1377
P01BB01 proguanil Dihydrofolate reductase antagonist; bifunctional dihydrofolate reductase-thymidylate synthase antagonist; substrate for Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2E1, Cytochrome P450 3A4; inhibits Cytochrome P450 2D6. Chloroguanide, Paludrine, Bigumal, Diguanyl, Drinupal, Guanatol, Paludrin, Palusil, Tirian

CHEMBL588912
P01BB02 cycloguanil embonate Dihydrofolate reductase inhibitor Camolar
Not Available P01BB51 proguanil, combinations Daramal Paludrine, Malanil, Malarone, Promal, Savarine

Diaminopyrimidines (2)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL36
P01BD01 pyrimethamine Dihydrofolate reductase inhibitor; Bifunctional dihydrofolate reductase-thymidylate synthase inhibitor; inhibits Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 2C8. Darachlor, Daraclor, Darapram, Daraprim, Daraprime, Disulone, Erbaprelina, Fansidar, Khloridin, Malacid, Malocid, Malocide, Maloprim, Pirimecidan, Tindurin, Tinduring
Not Available P01BD51 pyrimethamine, combinations Fansidar Tablets (Pyrimethamine + Sulfadoxine) Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline) Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

Dichloroacetamide derivatives (4)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL1334860
P01AC01 diloxanide Unknown. May impair adenine incorporation during RNA synthesis. Entamide, Ame-Boots, Amebamida
Not Available P01AC02 clefamide Reduced to produce free radicals which damage DNA. Mebinol, Moebinol
Not Available P01AC03 etofamide Reduced to produce free radicals which damage DNA. Kitnos
Not Available P01AC04 teclozan Reduced to produce free radicals which damage DNA. Falmonox

Imidazole derivatives (8)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL137
P01AB01 metronidazole Reduced to produce free radicals which damage DNA; potentiates oxygen-insensitive NADPH nitroreductase; inhibitor of periplasmic [Fe] hydrogenase 1. Rozex, Anabact, Neokit, Acromona, Anagiardil, Apo-Metronidazole, Arilin, Atrivyl, Bayer 5360, Bexon,, Clont, Cont, Danizol, Deflamon, Deflamon-Wirkstoff, Efloran, Elyzol, Entizol, Eumin, Flagemona, Flagesol, Flagil, Flagyl, Flagyl ER, Flagyl I.V., Flegyl, Fossyol, Giatricol, Gineflavir, Klion, Klont, Meronidal, Metric 21, Metro Cream, Metro I.V., Metro I.V. In Plastic Container, Metrocream, Metrogel, Metrogel-Vaginal, Metrolag, Metrolotion, Metrolyl, Metromidol, Metronidaz, Metrotop, Mexibol, Monagyl, Monasin, Nalox, Neo-Tric, Nida, Nidagel, Noritate, Novonidazol, Orvagil, Protostat, Rathimed, Sanatrichom, Satric, Takimetol, Trichazol, Trichex, Tricho Cordes, Tricho-Gynaedron, Trichocide, Trichomol, Trichopal, Trichopol, Tricocet, Tricom, Tricowas B, Trikacide, Trikamon, Trikojol, Trikozol, Trimeks, Trivazol, Vagilen, Vagimid, Vertisal, Wagitran, Zadstat

CHEMBL1220
P01AB02 tinidazole Reduced to produce free radicals which damage DNA; substrate for Cytochrome P450 3A4 Tindamax, Fasigyn, Protogyn

CHEMBL334654
P01AB03 ornidazole Reduced to produce free radicals which damage DNA. Alefox-OZ, Avrazor, Biteral, Borneral, Cefit-OZ, Dazolic, Edilox-OZ, Entamizole, Invigan, Mebaxol, Odicip-OZ , Oniz, OR-500, Orni, Ornid, Ornidone, Ornil, Ornisid, Ornitop, Ornizol, Qugyl-O, Robic, Tiberal, Troniz, Ulnid, Xynor, Zil

CHEMBL134920
P01AB04 azanidazole Reduced to produce free radicals which damage DNA. Premium Gamba, Triclose
Not Available P01AB05 propenidazole Reduced to produce free radicals which damage DNA. Naska

CHEMBL435966
P01AB06 nimorazole Reduced to form free radicals which damage DNA. Naxogin

CHEMBL498847
P01AB07 secnidazole Reduced to produce free radicals which damage DNA. Ambese, Amebin, Amecdal, Bianos, Daksol, Deprozol, Ecuzol, Esnidazol, Fazol, Flagentyl, Gisistin, Gynerium, Italnidazol, Maxidazol, Minovag, Noameba-DS, Nor-Secnal, Pazidol, Pleyazen, Raserdazol, Sabima, Secdazol, Secnezol, Secnichem, Secnid, Secnidal, Secnidazol Calox, Secnidazol Genfar, Secnidazol MK, Secnihexal, Secnil, Secnimed, Secni-Plus, Secnivax, Secnizol ratio, Secnizol, Secnol, Secsilen, Seczol, Sezol, Strebenzol, Tagera Forte, Unidazol, Xamex, Yardel

CHEMBL110
P01CA02 benznidazole Reduced to produce free radicals which damage DNA. Radanil, Rochagan

Isoquinolines (2)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL50588
P01AX02 emetine Inhibits the movement of the ribosome along messenger RNA by binding to the 40S subunit. Emetinum, Mebadine, Sigma

CHEMBL547470
P01AX09 dihydroemetine Inhibits the movement of the ribosome along messenger RNA by binding to the 40S subunit. Tilemetin

Methanolquinolines (2)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL170
P01BC01 quinine Ferriprotoporphyrin IX antagonist; affects platelet glycoprotein IX; blocks Intermediate conductance calcium-activated potassium channel protein 4; substrate for Cytochrome P450 3A5, Cytochrome P450 2E1, Cytochrome P450 3A7; inhibits Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2C19, Cytochrome P450 2D6; inhibits and induces Cytochrome P450 1A2, Cytochrome P450 1A1, Cytochrome P450 3A4; inhibits Solute carrier family 22 member 2, Solute carrier family 22 member 1, Organic cation/carnitine transporter 2, Multidrug resistance protein 1, Solute carrier organic anion transporter family member 1A2, Organic cation/carnitine transporter 1. Aflukin, Chinin, Chinine, Coco-Quinine, None, Quinine Dab

CHEMBL416956
P01BC02 mefloquine Ferriprotoporphyrin IX antagonist; Hemoglobin subunit alpha antagonist; Adenosine A2a receptor antagonist; inhibits Cytochrome P450 3A4, Cytochrome P450 19A1, Cytochrome P450 2D6, Multidrug resistance protein 1; inhibits cholinesterase. Lariamar, Mefloquinone, Meflotas, Apo-Mefloquine, Lariam,Larimef, Mefliam, Mefloc, Mephaquin, Mephaquine, Mequin, Tropicur

Naphthalenesulfonates (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL265502
P01CX02 suramin sodium P2Y purinoceptor 2 antagonist; NAD-dependent deacetylase sirtuin-5 antagonist; Follicle-stimulating hormone receptor antagonist; Ryanodine receptor 1 agonist; Prothrombin antagonist; Phospholipase A2, membrane associated antagonist; competitive inhibitor of heparin binding to many proteins, including viral envelope proteins, protein tyrosine phosphatases, and fibroblast growth factors (FGFs). Antrypol, Belganyl, Farma, Fourneau, Germanin, Moranyl Naganil, Naganin, Naganine, Naganol, Naphuride

Naphthoquinones (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL1450
P01AX06 atovaquone Inhibits the electron transport chain- cytochrome b antagonist, dihydroorotate dehydrogenase antagonist, cytochrome P450 inhibitor. Mepron, Wellvone

Nitrofuran derivatives (2)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL290960
P01CC01 nifurtimox Undergoes reduction followed by oxidation, thereby generating ROS; inhibits trypanothione reductase. Lampit

CHEMBL869
P01CC02 nitrofural Pyruvate dehydrogenase [cytochrome] antagonist; Glutathione reductase antagonist; Malate dehydrogenase antagonist; [Citrate [pro-3S]-lyase] ligase antagonist; reduced by xanthine oxidase; substrate for Cytochrome P450 2D6. Actin-N, Aldomycin, Alfucin, Amifur, Babrocid, Becafurazone, Biofuracina, Biofurea, Chemofuran, Chixin, Cocafurin, Coxistat, Dermofural, Dymazone, Dynazone, Eldezol, Eldezol F-6, Fedacin, Flavazone, Fracine, Furacilin, Furacillin, Furacin, Furacin Soluble Dressing, Furacin Topical Cream, Furacin Topical Solution, Furacin-E, Furacin-HC, Furacine, Furacinetten, Furacoccid, Furacort, Furacycline, Furaderm, Furagent, Furalcyn, Furaldon, Furalone, Furametral, Furan-Ofteno, Furaplast, Furaseptyl, Furaskin, Furatsilin, Furaziline, Furazin,, Furazina, Furazol W, Furazone, Furazyme, Furesol, Furfurinm, Furosem, Fuvacillin, Hemofuran, Ibiofural, Mammex, Mastofuran, Monafuracin, Monafuracis, Monofuracin, Nefco, NF-7, NFS, Nifucin, Nifurid, Nifuzon, Nitrofuran, Nitrofurane, Nitrofurazone, Nitrofurol, Nitrozone, Otofural, Otofuran, Sanfuran, Spray-Dermis, Spray-Foral, Vabrocid, Vadrocid, Yatrocin

Ornithine derivatives (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL830
P01CX03 eflornithine Irreversible inhibitor of ornithine decarboxylase (suicide inhibition). Vaniqa, Triton, Medison, SkinMedica, Ornidyl

Other (1)

Structure ATC Code Generic Name Mechanism Trade Names
Not Available P01AX52 emetine, combinations Antiseptico Dent Donner, Radipon, Doudol, Ipeca, Sano Tuss, Spirbon, Kodynal, Ipecarin, Rectopyrine, Cophylac Expectorant

Phenanthrenes (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL1107
P01BX01 halofantrine Ferriprotoporphyrin IX antagonist; Potassium voltage-gated channel subfamily H member 2 antagonist; Plasmepsin-2 antagonist; Substrate for Cytochrome P450 3A4, Cytochrome P450 2C8, Cytochrome P450 3A5; inhibitor of Cytochrome P450 2D6 Halfan

Phenanthrolines (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL531048
P01AX04 phanquinone Metal-chelating agent Entobex, Enthohex, Entronon

Quinazolines (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL119
P01AX07 trimetrexate Competitive inhibitor of dihydrofolate reductase Neutrexin

Quinoline derivatives (10)

Structure ATC Code Generic Name Mechanism Trade Names
Not Available P01AX01 chiniofon Anayodin, Ferron, Jod-Hydroxychinolin-Sulfonsaeure, Loretin, Meditrene, Quiniophen, Quinoxyl, Sefona, Yatren

CHEMBL76
P01BA01 chloroquine Ferriprotoporphyrin IX antagonist; inhibitor of Cytochrome P450 2D6; substrate for Cytochrome P450 1A1, Cytochrome P450 2C8, Cytochrome P450 3A4 and Cytochrome P450 3A5; inhibits Multidrug resistance protein 1. 3377 RP opalate, Amokin Aralen; Aralen HCl, Arechin, Arthrochin, Artrichin, Avlochlor, Avloclor, Bemaco, Bemaphate, Bemasulph, Benaquin, Bipiquin, Capquin. Chemochin, Chingamin, Chlorochin, Cidanchin, Cocartrit, Delagil, Dichinalex, Elestol, Gontochin, Heliopar, Imagon, Iroquine, Klorokin, Lapaquin, Malaquin, Malaren, Malarex, Mesylith, Neochin, Nivachine, Nivaquine, Nivaquine B, Pfizerquine, Plaquenil, Quinachlor, Quinagamin, Quinagamine, Quinercyl, Quingamine, Quinilon, Quinoscan, Resochen, Resochin, Resoquina, Resoquine, Reumachlor, Reumaquin, Roquine, Sanoquin, Silbesan, Siragan, Solprina, Sopaquin, Tanakan, Tresochin, Trochin

CHEMBL1535
P01BA02 hydroxychloroquine Cross-linking/alkylation of DNA; antagonist of Toll-like receptors 7 and 9; inhibits Cytochrome P450 2D6. Apo-Hydroxyquine, Axokine, Dolquine, Ercoquin ,Evoquin, Gen-Hydroxychloroquine, HCQS, Immard, Metirel, Mylan-Hydroxychloroquine, Narbon, Oxiklorin, Plaquenil, Plaquinol, Polirreumin, Pro-Hydroxyquine, Quensyl, Reuquinol

CHEMBL506
P01BA03 primaquine Ferriprotoporphyrin IX antagonist; inhibits ribosyldihydronicotinamide dehydrogenase [quinone]; inhibits Cytochrome P450 3A4, Cytochrome P450 2D6; induces Cytochrome P450 1A1, Cytochrome P450 1B1; both induces and inhibits Cytochrome P450 1A2. Neo-Quipenyl, Primachin, Malirid, PMQ-INGA, Primacin, Primacip, Primakinder

CHEMBL682
P01BA06 amodiaquine Forms an adduct with Ferriprotoporphyrin IX; histamine N-methyltransferase antagonist; substrate for Cytochrome P450 2C8, Cytochrome P450 1A1, Cytochrome P450 1B1; inhibits Cytochrome P450 2D6, Cytochrome P450 2C9. Basoquin, CAM-AQ1, CAM-AQI, Camochin, Camoquin, Camoquin HCL, Camoquinal, Camoquine, Flavoquin, Flavoquine, Miaquin

CHEMBL224325
P01AA04 chlorquinaldol Metal chelation; Inhibits RNA synthesis by chelation of Mn2+, Mg2+, and Zn2+ Chlorchinaldin, Clorchinaldol, Saprosan, Gynotherax, Sterosan, Steroxin
Not Available P01AA05 tilbroquinol May have therapeutic action due to metal-chelation. Intetrix P, Intetricine
Not Available P01AA52 clioquinol, combinations Dek-Quin, Ala-Quin, Iodo-HC, Steroform

CHEMBL223448
P01AA01 broxyquinoline Metal chelation; Inhibits RNA synthesis by chelation of Mn2+, Mg2+, and Zn2+ Starogyn, Brodiar, Broxykinolin, Colepur, Fenilor, Intensopan

CHEMBL497
P01AA02 clioquinol Metal-chelating agent, proteosome inhibitor. Ala-quin, Alchloquin, Alioform, Amebil, Amoenol, Bactol, Barquinol, Budoform, Chinoform, Chinoformum, Chlorojodochin, Cifoform, Cliochinolum, Cliquinol, Corque, Cort-quin, Cortin, Cremo-quin, Dermaform, Dioquinol, Domeform Domeform-HC, Eczecidin, Emaform, Enteritan, Entero-bio form, Entero-bioform,, Entero-septol, Entero-vioform, Entero-vioformio, Enteroquinol, Enteroseptol, Enterovalodon, Enterozol, Enterseptol, Enterum locorten, Entrokin, Formtone-HC, Hi-eneterol, Hi-enterol, Hydriodide-enterol, Hysone, Iodenterol, Iodoenterol, Lekosept, Lidaform-HC, Loquinol, Mycoquin, Nioform, Nystaform, Oralcer, Quin-o-creme, Quinambicide, Quinoform, Racet, Rheaform, Rometin, Uad lotion, Vioform, Vioform-hydrocortisone, Vioformio

Sulfur containing products (2)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL1082354
P01AX08 tenonitrozole Under aerobic and microaerophilic conditions, the hydrolysis of tenonitrozole may lead to the formation of a peroxynitrite anion, which is cytotoxic. Atricam, Atrican, Moniflagon, Thenitrazol, Tricosept, Neo-trichocid

CHEMBL1401
P01AX11 nitazoxanide Inhibits pyruvate-ferredoxin oxidoreductase Alinia, Fental, Phavic-1 Annita, Daxon, Dexidex, Kidonax, Pacovanton, Paramix, Nitax, Zox, Nitazox, Niazid,Toza

Terpenes (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL1232865
P01AX10 fumagillin Inhibitory ligand for methionine aminopeptidase 2 Fumagilin-B, Fugillin, Fumidil, Noceema-Fix, Flisint

P02 Antihelmintics (25)

Avermectins (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL341047
P02CF01 ivermectin Glycine receptor subunit alpha-3 agonist; Gamma-aminobutyric-acid receptor subunit beta-3 agonist; substrate for Cytochrome P450 3A4; inhibits Multidrug resistance protein 1, Multidrug resistance-associated protein 1, Canalicular multispecific organic anion transporter 1; substrate for ATP-binding cassette sub-family G member 2. Ivermectin B1, Ivermectin-luminol, Mectizan, Stromectol

Benzenesulfonates (1)

Structure ATC Code Generic Name Mechanism Trade Names
Not Available P02BX03 stibophen Inhibits phosphofructokinase Neoantimosan, Stibophenum, Fantorin, Fuadin, Trimon

Butyrophenones (1)

Structure ATC Code Generic Name Mechanism Trade Names
Not Available P02DX01 desaspidin Uncouples oxidative phosphorylation. Desaspidin BB, Rosapin

Imidazole derivatives (10)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL152632
P02BX02 niridazole Inhibits oogenesis and spermatogenesis; inhibits phosphofructokinase enzyme. Ambilgar, Ambilhar

CHEMBL1086440
P02BX04 triclabendazole Binds to beta-tubulin to prevent the polymerisation of microtubules Egaten, Fascinex, Fasinex, Soforen

CHEMBL685
P02CA01 mebendazole Tubulin alpha-3 chain antagonist; Tubulin beta-2C chain antagonist; substrate for Cytochrome P450 3A4; induces Cytochrome P450 1A1; inhibits Multidrug resistance protein 1. Bantenol, Besantin, Equivurm Plus, Lomper, MBDZ,, Mebenoazole, Mebenvet, Mebex, Mebutar, Noverme, Ovitelmin, Pantelmin, Telmin, Vermicidin, Vermirax, Vermox, Verpanyl

CHEMBL625
P02CA02 tiabendazole Fumarate reductase flavoprotein subunit inhibitor; inhibits Cytochrome P450 1A2, induces Cytochrome P450 1A1 Apl-Luster, Arbotect, Bioguard, Bovizole, Chemviron TK, 100, Cropasal, Drawipas, Eprofil, Equivet TZ, Equizole, Hokustar hp, Hymush, Lombristop, Mertec, Mertect, Metasol TK 10, Metasol TK 100, Mintesol, Mintezol, Minzolum, Mycozol, Nemacin, Nemapan, Omnizole, Ormogal, Polival, RPH, Sanaizol 100, Sistesan, Storite, TBZ 6, TBZ 60W, Tebuzate, Tecto, Testo, Thiaben, Thibendole, Thibenzol, Thibenzole, Thiprazole, Tiabenda, Tibimix 20, Tobaz, Top form wormer, Triasox, Tubazole

CHEMBL1483
P02CA03 albendazole Tubulin alpha-3 chain antagonist; Tubulin beta-2C chain antagonist; substrate for Cytochrome P450 3A4; induces Cytochrome P450 1A1; inhibits Multidrug resistance protein 1; inhibits and induces Cytochrome P450 1A2; Fumarate reductase flavoprotein subunit antagonist. Abentel, Alba-3, Albatel, Alben, Albenda, Albendol, Albendrox, Albendy, Albenix, Albensil, Albentel, Albenza, Albenzonil, Albex, Albezin, Albezol, Albezole, Alda, Aldamin, Alfazol, Alfuca, Alib, Alin, Alzental, Alzoben, Alzol, Amplozol, Andazol, Anthel, Bendapar, Bendex, Bentiamin, Benzol, Bevindazol, Bilutac, Bradelmin, Ceprazol, Champs D-Worms, Dabenzol, Dazocan, Dazol, Dazolin, Dezabil, Digezanol, Emanthal, Entoplus, Eskazole, Euralben, Flatezol, Gascop, Gendazel, Helal, Helmintal, Helmisons, Imavermil, Labenda, Leo-400, Lomsin, Loveral, Lurdex, Masaworm, Mebenix, Mesin, Monozol, Mycotel, Nemozole, Neo Bendazol, Olbendital, Olworm, Paranthil, Parasin, Proftril, Rivazol, Sanoxal, Serbendazol, Sostril, Taron, Tenibex, Thelban, Totelmin, Valbazen, Vastus, Vemizol, Verdazol, Vermiclase, Vermilan, Vermin-Plus, Vermisen, Vermital, Vermixide, Vermoil, Zeben, Zelfin, Zenaxin, Zental, Zentel, Zenzera, Zoben, Zolben, Zoldan
Not Available P02CA04 ciclobendazole Binds to beta-tubulin to inhibit microtubule formation Haptocil

CHEMBL1454946
P02CA05 flubendazole Binds to beta-tubulin to inhibit microtubule formation Flicum, Flubengal, Flubenol, Flumoxal, Flumoxane, Fluvermal, Fluvermox, Mansonil, Teniverme

CHEMBL37161
P02CA06 fenbendazole Tubulin destabiliser Panacur, Premelange 25 / 2 Porcs Medicamente, Safe-Guard, Zerofen
Not Available P02CA51 mebendazole, combinations Bot-Plus Syringe Formula Equine Wormer (Mebendazole + Trichlorfon) Equiverm B Pst (Mebendazole + Trichlorfon) Telmin B Syringe Formula (Mebendazole + Trichlorfon)

CHEMBL1454
P02CE01 levamisole Neuronal acetylcholine receptor subunit alpha-3 agonist; Alkaline phosphatase antagonist. Ergamisol, Ketrax, Lepuron, Levamisol, LEVOMYSOL, Nilverm base,Tetramisol, Tetramisole, Tramisol, Vermisol 150, Wormicid

Organophosphorous compounds (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL167150
P02BB01 metrifonate Irreversible organophosphate acetylcholinesterase inhibitor Bilarcil, ProMem, Metriphonate, Combot Pasta, Phoschlor R.50

Other antinematodals (1)

Structure ATC Code Generic Name Mechanism Trade Names
Not Available P02CX02 bephenium Nicotinic receptor agonist. Alcopara, Alcopar, Befenium, Debefenium, Francin, Nemex

Phenol derivatives (2)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL290106
P02BX01 bithionol Inhibits oxidative phosphorylation Actamer, Bidiphen, Bisoxyphen, Bithin, Bitin, Bitionol, Lorothidol, Lorothiodol, Neopellis, Nobacter, Prevenol, Vancide BL

CHEMBL33845
P02DX02 dichlorophen It uncouples oxidative phosphorylation which leads to a decrease in ATP synthesis. Anthiphen, Antifen, Antiphen, Cordocel, Dicestal, Didroxan, Didroxane, Difentan, Di-Phentane-70, Diphenthane 70, Embephen, Fungicide GM, Fungicide M, G-4 Pure, G-4 Technical, Gefir, Gingivit, Giv Gard G 4-40, Hyosan, Korium, Palacel, Panacide, Parabis, Plath-Lyse,, Prevental, Preventol GD, Preventol GDC, Sandocide, Sindar G 4, Super Mosstox, Taeniatol, Tapeworm, Teniathane, Teniatol, Tibs Tapeworml, Trivex, Vermithana, Wespuril

Piperazine and derivatives (2)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL1412
P02CB01 piperazine Gamma-aminobutyric-acid receptor subunit beta-3 agonist; substrate for Cytochrome P450 2D6 Anatensol, Antepan, Antepar, Antiren, Asca-Trol No. 3, Bryrel, Dapotum, Dispermine, Entacyl, Eraverm, Lumbrical, Lyogen, Moditen, Multifuge, Omca, Pacinol, Permitil, Piperazidine, Pipersol, Siqualone, Tasnon, Tensofin, Upixon, Uvilon, Valamina, Vermex, Vermidol, Vermizine, Worm-A-Ton, Worm-away, Wurmirazin

CHEMBL684
P02CB02 diethylcarbamazine Arachidonate 5-lipoxygenase antagonist; Prostaglandin G/H synthase 1 antagonist. Banocide, Bitirazine, Caracide, Carbilazine, Caricide, Cypip, Decacide, Ethodryl, Filaribits, Hetrazan, Notezine, Spatonin

Quinoline derivatives (3)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL976
P02BA01 praziquantel Induces calcium ion influx via the schistosome Calcium (Ca 2+) Channel; substrate for Cytochrome P450 3A4, Cytochrome P450 1A2, Cytochrome P450 2C19, Cytochrome P450 3A43, Cytochrome P450 3A5, Cytochrome P450 3A7; inhibits Cytochrome P450 2D6 Biltricide, Cesol, Cestoved , Cysticide , Droncit , Drontal (combination with pyrantel pamoate) , D-Worm , Kaicide , Milbemax (combination with milbemycin oxime) Popantel Tablets, Popantel F, PraziPro , Profender (combination with emodepside) , Tape Worm Tabs , Zentozide

CHEMBL847
P02BA02 oxamniquine It is thought that a schistosome sulfotransferase enzyme converts oxamniquine into an ester. The ester spontaneously dissociates, the resulting electrophilic reactant is capable of alkylation of schistosome DNA; inhibits Cytochrome P450 2D6. Mansil, Vansil

CHEMBL1201303
P02CX01 pyrvinium Inhibits carbohydrate metabolism; targets Casein Kinase 1_ to inhibit the Wnt signalling pathway; suppresses the transcriptional activation of GRP78 and GRP94 induced by glucose deprivation. Antioxiur, Alnoxi, Altolat, Enterocid, Molevac, Pamoxan, Polyquil, Povanyl, Pyrcon, Pyr-Pam, Pyrvin, Pyverm, Tru, Neooxypaat, Neo-Oxypate, Pamovin, Povan, Tolapin, Vanquin

Salicylic acid derivatives (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL1448
P02DA01 niclosamide Proton ionophore. Atenase, Bayluscid, Cestocid, Devermin, Devermine, Dichlosale, Fedal-Telmin, Fenasal, Helmiantin, Iomesan, Iomezan, Kontal, Lintex, Mansonil, Nasemo, Niclocide, Niclosan, Overoid, Phenasal, Radeverm, Sagimid, Sulqui, Telmitin, Unicide, Vermitid, Vermitin, Yomensan, Yomesan, Yomesane, Zestocarp

Tetrahydropyrimidine derivatives (2)

Structure ATC Code Generic Name Mechanism Trade Names
Not Available P02CC01 pyrantel Nicotinic receptor agonist; inhibits cholinesterase; stimulates Ach release. Pin-X, Pinworm Medicine, Antiminth, Ascarel, Pamix, Bifantrel, Combantrin, Helmintox, Pirantel Pamoato MK, Pirantelis, Pyrantin, Anthel, Ascarical, Cobantril, Delentin, Early Bird, Helmex, HRT, Kontil, Lombriareu, Melphin, Nemocid, Pamoato de Pirantel Genfar, Pamoato de Pirantel La Sante, Pamoato de Pirantel, Pamox, Panatel-125, Pirantel Pamoato Genfar, Pirantel, Piraska, Pirel, Pyrantelum, Pyrantin, Reese's Pinworm Medicine, Tamoa, Trilombrin, Vertel,

CHEMBL1240977
P02CC02 oxantel Nicotinic receptor agonist; inhibits cholinesterase; stimulates Ach release. Telopar

P03 Ectoparasiticides (31)

Benzoic acid dervatives (2)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL1239
P03AX01 benzyl benzoate Act on the nervous system of the parasite. Ascabin, Ascabiol, Benylate, Benzoic acid , Benzyl benzenecarboxylate, Benzyl benzoate 99+ %, Benzyl ester, Benzyl phenylformate, Benzylester kyseliny benzoove, Benzylets, Colebenz, Novoscabin, Peruscabin, Scabagen, Scabanca, Scabide, Scabiozon, Scabitox, Scobenol, Vanzoate, Venzoate, Venzonate

CHEMBL1453317
P03BX01 diethyltoluamide Mosquitoe neurones (in their antennae) detect diethyltoluamide (DEET). The mosquito does not bite because it does not like the smell of diethyltoluamide. Amincene C 140, Amincene C-EM, Autan, Bens, Bepper DET, Bug Guards, Bugzzz Away, Cutter, Deep Woods OFF, Detamide, Dieltamid, Dusk, Flypel, Insect Ecran Spray, Item Antipoux Spray, Jungle Formula Insect Repellent, Konk, Lozione Cruz Verde Zanzara, Mijex, Moskizol Gel, Muskol, Mylol Spray, Naugatuck DET, Off, Off Skintastic, Repel, Repper DET, Repudin-Special, Ultrathon, Ungava

Chlorine containing products (3)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL416898
P03AB01 clofenotane Acts on neuronal voltage-gated sodium channels causing slow open and closing characteristics of the channel; induces cytochrome P450. Aavero-Extra, Agritan, Anofex, Arkotine, Azotox, Azotox M 33, Benzochloryl, Bosan Supra, Bovidermol, Dedelo, Deoval, Detoxan, Dibovan, Dibovin, Dicophane, Didigam, Didimac, Dodat, Dykol, Estonate, Genitox, Gesafid, Gesapon, Gesarex, Gesarol, Geusapon, Guesapon, Guesarol, Gyron, Havero-Extra, Hildit, Ivoran, Ixodex, Kopsol, Micro DDT 75, Mutoxan, Mutoxin, Pentech, Penticidum, Polvere Cruz Verde, Ppzeidan, Rukseam, Santobane, Tafidex, Tech DDT, Zeidane, Zerdane

CHEMBL15891
P03AB02 lindane Gamma-aminobutyric-acid receptor subunit beta-1 antagonist; Glycine receptor subunit alpha-1 antagonist; Glycine receptor subunit alpha-2 antagonist; Glycine receptor subunit alpha-3 antagonist; Glycine receptor subunit beta antagonist. Aalindan. Aficide, Agrocide, Agrocide III, Agrocide WP, Ameisenmittel merck, Ameisentod, Aparasin, Aphtiria, Aplidal, Arbitex, Atlas steward, BBH, Ben-Hex, Bentox 10, Benzene hexachloride, beta-BHC, beta Hexachlorocyclohexane, beta-Lindane, Bexol, Celanex, Chloresene, Codechine, DBH, Detmol-Extrakt, Devoran, Dol Granule, Drilltox-Spezial, Aglukon, Entomoxan, Esoderm, Fumite lindane, Gamacid, Gamene, Gamma-BHC dust, Gamma-Col, Gamma-HCH dust, Gammalin, Gammalin 20, Gammasan, Gammaterr, Gammexane, Gexane, HCCH, HCH, Heclotox, Hexa, Hexachloran, Hexachlorane, Hexachlorocyclohexane, Hexatox,, Hexaverm, Hexicide, Hexit, Hexyclan, HGI, Hortex, Indane, Isotox, Jacutin, Kokotine, Kwell, Lendine, Lentox, Lidenal, Lindafor, Lindatox, Lindex, Lindosep, Lintox, Linvur, Lorexane, Milbol 49, Mszycol, Murfume grain store smoke, Neo-Scabicidol, New kotol, Nexen FB, Nexit, Nexit-Stark, Nexol-E, Nicochloran, Omnitox, Ovadziak, Owadziak, Pedraczak, Pflanzol, PMS, Lindane, Quellada, Sang-gamma, Scabene, Scabene lotion, Spritz-Rapidin, Spruehpflanzol, Streunex, TAP 85, Thionex, Tri-6, Viton
Not Available P03AB51 clofenotane, combinations

Glycols (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL1451179
P03BX06 etohexadiol

Nitrobenzenes (1)

Structure ATC Code Generic Name Mechanism Trade Names
Not Available P03BX04 dibutylsuccinate Tabatrex, Tabutrex

Organophosphorus compounds (1)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL1200468
P03AX03 malathion Inhibits cholinesterase; substrate for Cytochrome P450 1A2, Cytochrome P450 2B6. Calmathion, Carbethoxy malathion, Carbetovur, Carbetox, Celthion, Chemathion, Cimexan, Cleensheen, Cythion, Derbac-M, Detmol MA, Emmatos, Emmatos extra, Ethiolacar, Etiol, Extermathion, Fog 3, Formal, Forthion, Fosfothion, Fosfotion, Fosfotion 550, Fyfanon, Hilthion, Hilthion 25WDP, Karbofos, Kop-thion, Kop-Thionkypfosmalacide, Kypfos, Latka 4049, Lice Rid, Malacide, Malafor, Malagran, Malakill, Malamar, Malamar 50, Malaphele, Malaphos, Malasol, Malaspray, Malathion 60, Malathion E50, Malathion LV Concentrate, Malathiozoo, Malathon, Malation, Malatol, Malatox, Malmed, Malphos, Maltox, Maltox MLT, Moscarda, OMS 1, Organoderm, Ortho Malathion, Ovide, Phosphothion, Prioderm, Sadofos, Sadofos 30, Sadophos, Siptox I, Staeubol-Puder, Suleo-M, Sumitox, TAK, Taskil, Vegfru malatox, Vetiol, Zithiol

Other (3)

Structure ATC Code Generic Name Mechanism Trade Names
Not Available P03AX02 copper oleinate
Not Available P03AX04 quassia Cuassicum Prevent 2 en 1, Quassia Amara, Quassia Amara Injeel
Not Available P03BX05 dimethylcarbate

Pthalic acid (2)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL323348
P03BX02 dimethylphthalate Avolin, Fermine, Mipax, Palatinol M, Repeftal, Solvanom, Solvarone, Unimoll DM

CHEMBL272485
P03BX03 dibutylphthalate

Pyrethrines, incl. synthetic compounds (12)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL563221
P03AC01 pyrethrum Binds to voltage-gated sodium channels to prolong their open duration. Buhach, Chrysanthemum Leucanthemum, Cinerin I, Cinerin II, Dalmatian Insect Powder, Dalmation Insect Flowers, Firmotox, Insect Powder, Jasmolin I, Jasmolin II, Moskill, Persian Insect Powder, Prentox Pyrethrum Extract, Pyrocide, Pyronyl, Trieste Flowers
Not Available P03AC02 bioallethrin Binds to voltage-gated sodium channels to prolong their open duration. Pallethrine, Allethrine, Esbiothrin, Pynamin, Pyresin, Pyresyn, Pyrethrin, Zanzevia Spiral

CHEMBL1322884
P03AC03 phenothrin Binds to voltage-gated sodium channels to prolong their open duration. Anchimanaito 20S, Anti-Bit, Anvil, Anvil 10 + 10 ULV, Anvil 2 + 2 ULV, Cruzzy Shampoo Potenziato alla, Sumitrina, Igienico Terapeutiche, Full Marks Liquid, Full Marks Lotion, Full Marks Mousse, Headmaster, Herklin NF Shampoo, Itax Antipoux Shampoo, Item Antipoux, Ivaliten, Killkina, Mediker, Mom Gel, Mom Shampoo, Schiuma, Multicide 2154, Multicide Concentrate F-2271, Nopucid MC, Ottocid, Parasidose, Pibutin, Pronto Surface Spray, Sitem, Sof-Sof, Solo, Solo Insecticide, Sumithrin , Sumitrin, Sumo, Wellcide

CHEMBL1525
P03AC04 permethrin Sodium channel protein type 1 subunit alpha blocker; induces and is a substrate for Cytochrome P450 2B6; substrate for Cytochrome P450 3A4 Acticin Cream, Elimite, Elimite Cream, Lyclear, Nix, Nix Cream Rinse, PerFoam
Not Available P03AC51 pyrethrum, combinations
Not Available P03AC52 bioallethrin, combinations
Not Available P03AC53 phenothrin, combinations
Not Available P03AC54 permethrin, combinations
Not Available P03BA01 cyfluthrin Binds to voltage-gated sodium channels to prolong their open duration. Bayofly Pour-on, Prolong Fly and Litter Beetle Insecticide, Responsar, Solfac, Syfrutrin

CHEMBL373204
P03BA02 cypermethrin Binds to voltage-gated sodium channels to prolong their open duration. Agrothrin, Ambush C, Ambush CY, Ammo, Antiborer 3767, Ardap, Arrivo, Asymmethrin, Barricade 10EC, Basathrin, Chinmix, Colt, Creokhin, Cymbush, Cympa-Ti, Cymperator, Cypercare, Cyperco, Cypercopal, Cyperil, Cyperkill, Cypermethrin-25EC, Cypersect, Cypor, Cyrux, Demon, Demon TC, Drago, Dysect, Ecofleece Sheep Dip, Ectomin, Ectopor, Excis, Fenom, Flectron, Fury, Fury Insecticide, Hilcyperin, Kordon, Kreokhin, Mustang, Neramethrin, Neramethrin EC 50, Nurele, Nurelle, Polytrin, Ripcord, Rycopel, Sherpa, Siperin, Supercypermethrin, Supercypermethrin Forte, Topclip, Parasol, Toppel, Ustaad, Vucht 424

CHEMBL1593566
P03BA03 decamethrin Binds to voltage-gated sodium channels to prolong their open duration. Butoss, Cinq sur Cinq Mosquito Net, Cislin, Crackdown, Decis, Del-Lend, Comercio, Deltacid, Deltacide, DeltaGard, Deltagran, Deltalab, Deltamitren, Deltapio, Deltasay, Deotrin, Difexon, Dynastia, Esbecythrin, Glossinex 200, Hexafen, K-O Tab, K-Obiol, K-Othrin, K-Othrine, Neolend , New Musigie, Nopucid , Pediderm , Phagase 1, Piroli-N , Sifdel , Stricker, Suspend, Zodiac, Zorcis
Not Available P03BA04 tetramethrin Binds to voltage-gated sodium channels to prolong their open duration. Bioneopynamin, Neopinamin, Phthalthrinm Tetramethrine, Insectol, Multicide, Tetralate

Sulfur containing products (6)

Structure ATC Code Generic Name Mechanism Trade Names

CHEMBL331743
P03AA01 dixanthogen Auligen, Aulinogen, Bexide, Dixan, Galasan, Herbisan, Herbisan 5, Herbisan N5, K Preparation, Lenisarin, Preparation K, Scabicidol, Silfasan, Skabilan, Xantoscabin
Not Available P03AA02 potassium polysulfide
Not Available P03AA03 mesulfen Citemul S, Mitigal, Perozon Schwefel-Olba, Shampoo Potenziato Cruz Verde Allo Zolfo Organico, Thiantholum

CHEMBL964
P03AA04 disulfiram Aldehyde dehydrogenase antagonist; Dopamine beta-hydroxylase antagonist; inhibits Cytochrome P450 2E1, Cytochrome P450 2C9; substrate for Cytochrome P450 3A4, Cytochrome P450 3A5. Abstensil, Abstinil, Abstinyl, Accel Tet, Accel Tet-R, Akrochem Tetd, Alcophobin, Alk-Aubs, Ancazide Et, Antabus, Antabuse, Antadix, Antaenyl, Antaethan,, Antaethyl, Antaetil, Antalcol, Antetan, Antethyl, Antetil, Anteyl, Anthethyl, Anti-Ethyl, Antiaethan, Anticol, Antietanol, Antietil, Antikol, Antivitium, Aversan, Averzan, Bonibal, Contralin, Contrapot, Cronetal, Dicupral, Disetil, Disulfan, Disulfram, Ekagom Dtet, Ekagom Teds, Ekagom Tetds, Ekaland Tetd, Ephorran, Espenal, Esperal, Etabus, Ethyl Thiram, Ethyl Thiudad, Ethyl Thiurad, Ethyl Tuads, Ethyl Tuads Rodform, Ethyl Tuex, Ethyldithiourame, Ethyldithiurame, Etyl Tuex, Exhoran, Exhorran, Gababentin, Hoca, Krotenal, Nocbin, Nocceler Tet, Nocceler Tet-G, Noxal, Perkacit Tetd, Perkait Tetd, Refusal, Ro-Sulfiram, Sanceler Tet, Sanceler Tet-G, Soxinol Tet, Stopaethyl, Stopethyl, Stopet, Stopetyl, Super Rodiatox, Tenurid, Tenutex, Tetidis, Tetradin, Tetradine, Tetraetil, Teturam, Teturamin, Thiocid, Thiophos, Thioscabin, Thireranide, Tillram, Tiuram, TTS, TTS X

CHEMBL120563
P03AA05 thiram Inhibits aldehyde dehydrogenase Nobecutan, Sadoplon 75, Tetrasipton, Aatiram, Falitiram, Rezifilm, Aapirol
Not Available P03AA54 disulfiram, combinations
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