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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6183
Target Type SINGLE PROTEIN
Preferred Name Neuronal acetylcholine receptor subunit alpha-6
Synonyms Chrna6 | Neuronal acetylcholine receptor subunit alpha-6 | Nica6
Organism Mus musculus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit alpha-6 SINGLE PROTEIN Q9R0W9

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3350222 Neuronal nicotinic acetylcholine receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004889 (acetylcholine-activated cation-selective channel activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005515 (protein binding)
GO:0015464 (acetylcholine receptor activity)
GO:0042166 (acetylcholine binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0007165 (signal transduction)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007274 (neuromuscular synaptic transmission)
GO:0014059 (regulation of dopamine secretion)
GO:0034220 (ion transmembrane transport)
GO:0035094 (response to nicotine)
GO:0051899 (membrane depolarization)
GO:0098655 (cation transmembrane transport)
GO:0099565 (chemical synaptic transmission, postsynaptic)

Target Cross References - Protein

Reactome R-MMU-629594 (Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.)
R-MMU-629597 (Highly calcium permeable nicotinic acetylcholine receptors.)
UniProt Q3UEY4 Q8K0A7 Q9R0W9

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR027361 (Acetylcholine_rcpt_TM.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
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