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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6183
Target Type SINGLE PROTEIN
Preferred Name Neuronal acetylcholine receptor subunit alpha-6
Synonyms Chrna6 | Neuronal acetylcholine receptor subunit alpha-6 | Nica6
Organism Mus musculus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit alpha-6 SINGLE PROTEIN Q9R0W9

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885611 Neuronal acetylcholine receptor subunit alpha-6/beta-2 PROTEIN COMPLEX
CHEMBL3885610 Neuronal acetylcholine receptor subunit alpha-4/alpha-6/beta-2/beta-3 PROTEIN COMPLEX
CHEMBL3350222 Neuronal nicotinic acetylcholine receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0022848 (acetylcholine-gated cation channel activity)
GO:0042166 (acetylcholine binding)
GO Biological Process GO:0006811 (ion transport)
GO:0007165 (signal transduction)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007274 (neuromuscular synaptic transmission)
GO:0014059 (regulation of dopamine secretion)
GO:0033603 (positive regulation of dopamine secretion)
GO:0034220 (ion transmembrane transport)
GO:0035094 (response to nicotine)
GO:0051291 (protein heterooligomerization)
GO:0051899 (membrane depolarization)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0060079 (excitatory postsynaptic potential)

Target Cross References - Protein

Reactome R-MMU-629594 (Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.)
R-MMU-629597 (Highly calcium permeable nicotinic acetylcholine receptors.)
UniProt Q3UEY4 Q8K0A7 Q9R0W9

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
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