ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL6124
Preferred Name Histidine kinase
Synonyms AHK4 | Arabidopsis histidine kinase 4 | AtCRE1 | AtHK4 | CRE1 | Cytokinin receptor CRE1 | Cytokinin receptor CYTOKININ RESPONSE 1 | Histidine kinase 4 | Phosphoprotein phosphatase AHK4 | Protein AUTHENTIC HIS-KINASE 4 | Protein ROOT AS IN WOL 1 | Protein WOODEN LEG | RAW1 | WOL
Organism Arabidopsis thaliana
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Histidine kinase 4 SINGLE PROTEIN Q9C5U0

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0000155 (phosphorelay sensor kinase activity)
GO:0004673 (protein histidine kinase activity)
GO:0004721 (phosphoprotein phosphatase activity)
GO:0005515 (protein binding)
GO:0009884 (cytokinin receptor activity)
GO:0009885 (transmembrane histidine kinase cytokinin receptor activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0016772 (transferase activity, transferring phosphorus-containing groups)
GO:0016787 (hydrolase activity)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0019955 (cytokine binding)
GO:0043424 (protein histidine kinase binding)
GO Biological Process GO:0000160 (phosphorelay signal transduction system)
GO:0006468 (protein phosphorylation)
GO:0006470 (protein dephosphorylation)
GO:0007165 (signal transduction)
GO:0007231 (osmosensory signaling pathway)
GO:0007275 (multicellular organism development)
GO:0008272 (sulfate transport)
GO:0009414 (response to water deprivation)
GO:0009736 (cytokinin-activated signaling pathway)
GO:0010029 (regulation of seed germination)
GO:0010086 (embryonic root morphogenesis)
GO:0010150 (leaf senescence)
GO:0016036 (cellular response to phosphate starvation)
GO:0016310 (phosphorylation)
GO:0018106 (peptidyl-histidine phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0033500 (carbohydrate homeostasis)
GO:0042742 (defense response to bacterium)
GO:0048509 (regulation of meristem development)
GO:0048831 (regulation of shoot system development)
GO:0071329 (cellular response to sucrose stimulus)

Target Cross References - Protein

canSAR Q9C5U0
IntAct Q9C5U0
UniProt A5YY60 A5YY75 Q9C5T8 Q9C5T9 Q9C5U0 Q9FDZ3 Q9SIT0

Target Cross References - Domain

InterPro IPR000836 (PRibTrfase_dom.)
IPR001789 (Sig_transdc_resp-reg_receiver.)
IPR003594 (HATPase_C.)
IPR003661 (HisK_dim/P.)
IPR004358 (Sig_transdc_His_kin-like_C.)
IPR005467 (His_kinase_dom.)
IPR006189 (CHASE_dom.)
IPR011006 (CheY-like_superfamily.)
Pfam PF00072 (Response_reg)
PF00512 (HisKA)
PF02518 (HATPase_c)
PF03924 (CHASE)

Target Cross References - Structure

PDBe 3T4J 3T4K 3T4L 3T4O 3T4Q 3T4S 3T4T
CREDO 3T4J 3T4K 3T4L 3T4O 3T4Q 3T4S 3T4T