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Target Report Card

Target Name and Classification

Target ID CHEMBL6121
Preferred Name Disintegrin and metalloproteinase domain-containing protein 33
Synonyms ADAM 33 | ADAM33 | C20orf153 | Disintegrin and metalloproteinase domain-containing protein 33
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12b subfamily

Target Components

Component Description Relationship Accession
Disintegrin and metalloproteinase domain-containing protein 33 SINGLE PROTEIN Q9BZ11

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000149451
Ensembl ENSG00000149451
GO Cellular Component GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
Wikipedia ADAM33

Target Cross References - Protein

canSAR Q9BZ11
Human Protein Atlas ENSG00000149451
IntAct Q9BZ11
Guide to Pharmacology 1673
Open Targets ENSG00000149451
PharmGKB PA24526
UniProt A0A1K6 Q5JT75 Q5JT76 Q8N0W6 Q9BZ11

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR001590 (Peptidase_M12B.)
IPR001762 (Disintegrin_dom.)
IPR002870 (Peptidase_M12B_N.)
IPR006586 (ADAM_Cys-rich.)
IPR013032 (EGF-like_CS.)
IPR018358 (Disintegrin_CS.)
IPR024079 (MetalloPept_cat_dom_sf.)
IPR034027 (Reprolysin_adamalysin.)
IPR036436 (Disintegrin_dom_sf.)
Pfam PF00200 (Disintegrin)
PF01421 (Reprolysin)
PF01562 (Pep_M12B_propep)
PF08516 (ADAM_CR)

Target Cross References - Structure

PDBe 1R54 1R55
CREDO 1R54 1R55