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Target Report Card

Target Name and Classification

Target ID CHEMBL6082
Preferred Name Serine/threonine-protein kinase SIK1
Synonyms SIK | SIK-1 | SIK1 | SNF1LK | Salt-inducible kinase 1 | Serine/threonine-protein kinase SIK1 | Serine/threonine-protein kinase SNF1-like kinase 1 | Serine/threonine-protein kinase SNF1LK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase qik subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase SIK1 SINGLE PROTEIN P57059

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142178
Ensembl ENSG00000142178
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008140 (cAMP response element binding protein binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0046872 (metal ion binding)
GO:0071889 (14-3-3 protein binding)
GO Biological Process GO:0002028 (regulation of sodium ion transport)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007275 (multicellular organism development)
GO:0007346 (regulation of mitotic cell cycle)
GO:0010830 (regulation of myotube differentiation)
GO:0010868 (negative regulation of triglyceride biosynthetic process)
GO:0016310 (phosphorylation)
GO:0030154 (cell differentiation)
GO:0032792 (negative regulation of CREB transcription factor activity)
GO:0032870 (cellular response to hormone stimulus)
GO:0035556 (intracellular signal transduction)
GO:0043153 (entrainment of circadian clock by photoperiod)
GO:0045595 (regulation of cell differentiation)
GO:0045721 (negative regulation of gluconeogenesis)
GO:0046777 (protein autophosphorylation)
GO:0048511 (rhythmic process)
GO:0055007 (cardiac muscle cell differentiation)
GO:2000210 (positive regulation of anoikis)
Wikipedia SNF1LK

Target Cross References - Protein

canSAR P57059
Human Protein Atlas ENSG00000142178
IntAct P57059
Guide to Pharmacology 2197
Open Targets ENSG00000142178
PharmGKB PA164725717
Pharos P57059 (Tchem)
Reactome R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
UniProt A6NC84 P57059 Q5R2V5 Q6ZNL8 Q86YJ2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR015940 (UBA.)
IPR017090 (Ser/Thr_kinase_SIK1/2.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR034672 (SIK.)
Pfam PF00069 (Pkinase)