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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6044
Target Type SINGLE PROTEIN
Preferred Name Bcl-2-related protein A1
Synonyms BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | Bcl-2-related protein A1 | Bcl2-L-5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Bcl-2-related protein A1 SINGLE PROTEIN Q16548

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2107358 OBATOCLAX MESYLATE Bcl-2-related protein A1 inhibitor 3 PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140379
Ensembl ENSG00000140379
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005741 (mitochondrial outer membrane)
GO Molecular Function GO:0005515 (protein binding)
GO:0015267 (channel activity)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001836 (release of cytochrome c from mitochondria)
GO:0006915 (apoptotic process)
GO:0008053 (mitochondrial fusion)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0055085 (transmembrane transport)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
Wikipedia BCL2-related_protein_A1

Target Cross References - Protein

canSAR Q16548
Human Protein Atlas ENSG00000140379
IntAct Q16548
Open Targets ENSG00000140379
PharmGKB PA25303
UniProt Q16548 Q6FGZ4 Q6FH19 Q86W13 Q99524

Target Cross References - Domain

InterPro IPR002475 (Bcl2-like.)
IPR013282 (Bcl2A1.)
IPR020717 (Bcl2_BH1_motif_CS.)
IPR020726 (Bcl2_BH2_motif_CS.)
IPR026298 (Blc2_fam.)
Pfam PF00452 (Bcl-2)

Target Cross References - Structure

PDBe 2VM6 3I1H 3MQP 4ZEQ
CREDO 2VM6 3I1H 3MQP 4ZEQ
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