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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6040
Target Type SINGLE PROTEIN
Preferred Name Genome polyprotein
Synonyms Capsid protein C | Core protein p19 | Core protein p21 | Envelope glycoprotein E1 | Envelope glycoprotein E2 | Genome polyprotein | Hepacivirin | NS1 | NS3P | NS4A | NS4B | NS5A | NS5B | Non-structural protein 4A | Non-structural protein 4B | Non-structural protein 5A | Protease NS2-3 | RNA-directed RNA polymerase | Serine protease NS3 | gp32 | gp35 | gp68 | gp70 | p21 | p23 | p27 | p56 | p68 | p70
Organism Hepatitis C virus genotype 1b (isolate BK) (HCV)
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Genome polyprotein SINGLE PROTEIN P26663

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0019012 (virion)
GO:0019013 (viral nucleocapsid)
GO:0019028 (viral capsid)
GO:0019031 (viral envelope)
GO:0020002 (host cell plasma membrane)
GO:0030430 (host cell cytoplasm)
GO:0033644 (host cell membrane)
GO:0033650 (host cell mitochondrion)
GO:0042025 (host cell nucleus)
GO:0044164 (host cell cytosol)
GO:0044165 (host cell endoplasmic reticulum)
GO:0044167 (host cell endoplasmic reticulum membrane)
GO:0044186 (host cell lipid particle)
GO:0044191 (host cell mitochondrial membrane)
GO:0044220 (host cell perinuclear region of cytoplasm)
GO:0044385 (integral to membrane of host cell)
GO:0055036 (virion membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0002020 (protease binding)
GO:0003723 (RNA binding)
GO:0003824 (catalytic activity)
GO:0003968 (RNA-directed RNA polymerase activity)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0004386 (helicase activity)
GO:0005198 (structural molecule activity)
GO:0005216 (ion channel activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008026 (ATP-dependent helicase activity)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0008270 (zinc ion binding)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO:0016787 (hydrolase activity)
GO:0017111 (nucleoside-triphosphatase activity)
GO:0017124 (SH3 domain binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001172 (transcription, RNA-templated)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006508 (proteolysis)
GO:0006811 (ion transport)
GO:0008152 (metabolic process)
GO:0016032 (viral process)
GO:0019062 (virion attachment to host cell)
GO:0019087 (transformation of host cell by virus)
GO:0030683 (evasion or tolerance by virus of host immune response)
GO:0034220 (ion transmembrane transport)
GO:0039502 (suppression by virus of host type I interferon-mediated signaling pathway)
GO:0039503 (suppression by virus of host innate immune response)
GO:0039520 (induction by virus of host autophagy)
GO:0039545 (suppression by virus of host MAVS activity)
GO:0039547 (suppression by virus of host TRAF activity)
GO:0039563 (suppression by virus of host STAT1 activity)
GO:0039645 (modulation by virus of host G1/S transition checkpoint)
GO:0039654 (fusion of virus membrane with host endosome membrane)
GO:0039663 (membrane fusion involved in viral entry into host cell)
GO:0039694 (viral RNA genome replication)
GO:0039707 (pore formation by virus in membrane of host cell)
GO:0046718 (viral entry into host cell)
GO:0051259 (protein oligomerization)
GO:0060153 (modulation by virus of host cell cycle)
GO:0075509 (endocytosis involved in viral entry into host cell)
GO:0075512 (clathrin-mediated endocytosis of virus by host cell)

Target Cross References - Protein

canSAR P26663
IntAct P26663
UniProt P26663

Target Cross References - Domain

InterPro IPR000745 (HCV_NS4a.)
IPR001490 (HCV_NS4b.)
IPR001650 (Helicase_C.)
IPR002166 (RNA_pol_HCV.)
IPR002518 (HCV_NS2.)
IPR002519 (HCV_env.)
IPR002521 (HCV_core_C.)
IPR002522 (HCV_core_N.)
IPR002531 (HCV_NS1.)
IPR002868 (HCV_NS5a.)
IPR004109 (Peptidase_S29_NS3.)
IPR007094 (RNA-dir_pol_PSvirus.)
IPR009003 (Peptidase_S1_PA.)
IPR011492 (DEAD_Flavivir.)
IPR013192 (NS5A_1a.)
IPR013193 (HCV_NS5a_1B_dom.)
IPR014001 (Helicase_ATP-bd.)
IPR024350 (HCV_NS5a_C.)
IPR027417 (P-loop_NTPase.)
Pfam PF00998 (RdRP_3)
PF01001 (HCV_NS4b)
PF01006 (HCV_NS4a)
PF01506 (HCV_NS5a)
PF01538 (HCV_NS2)
PF01539 (HCV_env)
PF01542 (HCV_core)
PF01543 (HCV_capsid)
PF01560 (HCV_NS1)
PF02907 (Peptidase_S29)
PF07652 (Flavi_DEAD)
PF08300 (HCV_NS5a_1a)
PF08301 (HCV_NS5a_1b)
PF12941 (HCV_NS5a_C)

Target Cross References - Structure

PDBe 1A1Q 1C2P 1CSJ 1CU1 1GX5 1GX6 1JXP 1NHU 1NHV 1NS3 1OS5 1QUV 2AWZ 2AX0 2AX1 2BRK 2BRL 2DXS 2GIQ 2GIR 2HAI 2HWH 2HWI 2I1R More...
CREDO 1A1Q 1C2P 1CSJ 1CU1 1GX5 1GX6 1JXP 1NHU 1NHV 1NS3 1OS5 1QUV 2AWZ 2AX0 2AX1 2BRK 2BRL 2DXS 2GIQ 2GIR 2HAI 2HWH 2HWI 2I1R More...
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