ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL6030
Preferred Name Eukaryotic translation initiation factor 2-alpha kinase 3
Synonyms EIF2AK3 | Eukaryotic translation initiation factor 2-alpha kinase 3 | HsPEK | PEK | PERK | PRKR-like endoplasmic reticulum kinase | Pancreatic eIF2-alpha kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase pek family > other protein kinase pek subfamily

Target Components

Component Description Relationship Accession
Eukaryotic translation initiation factor 2-alpha kinase 3 SINGLE PROTEIN Q9NZJ5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000172071
Ensembl ENSG00000172071
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030176 (integral component of endoplasmic reticulum membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004694 (eukaryotic translation initiation factor 2alpha kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0019903 (protein phosphatase binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0051879 (Hsp90 protein binding)
GO Biological Process GO:0001501 (skeletal system development)
GO:0001503 (ossification)
GO:0001525 (angiogenesis)
GO:0002063 (chondrocyte development)
GO:0006417 (regulation of translation)
GO:0006468 (protein phosphorylation)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006983 (ER overload response)
GO:0006986 (response to unfolded protein)
GO:0007029 (endoplasmic reticulum organization)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010628 (positive regulation of gene expression)
GO:0010998 (regulation of translational initiation by eIF2 alpha phosphorylation)
GO:0016310 (phosphorylation)
GO:0017148 (negative regulation of translation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0019722 (calcium-mediated signaling)
GO:0030282 (bone mineralization)
GO:0030968 (endoplasmic reticulum unfolded protein response)
GO:0031018 (endocrine pancreas development)
GO:0031642 (negative regulation of myelination)
GO:0032055 (negative regulation of translation in response to stress)
GO:0032057 (negative regulation of translational initiation in response to stress)
GO:0034198 (cellular response to amino acid starvation)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0036492 (eiF2alpha phosphorylation in response to endoplasmic reticulum stress)
GO:0036499 (PERK-mediated unfolded protein response)
GO:0042149 (cellular response to glucose starvation)
GO:0045943 (positive regulation of transcription from RNA polymerase I promoter)
GO:0046777 (protein autophosphorylation)
GO:0048009 (insulin-like growth factor receptor signaling pathway)
GO:0051260 (protein homooligomerization)
GO:0060734 (regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)
GO:0070417 (cellular response to cold)
GO:1900182 (positive regulation of protein localization to nucleus)
GO:1902235 (regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)
GO:1990737 (response to manganese-induced endoplasmic reticulum stress)
Wikipedia EIF2AK3

Target Cross References - Protein

CGD Wolcott-Rallison syndrome
Human Protein Atlas ENSG00000172071
IntAct Q9NZJ5
Guide to Pharmacology 2017
Open Targets ENSG00000172071
PharmGKB PA27687
Pharos Q9NZJ5 (Tchem)
Reactome R-HSA-381042 (PERK regulates gene expression.)
UniProt A0AVH1 A0AVH2 B2RCU9 O95846 Q53QY0 Q53SB1 Q9NZJ5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011047 (Quinoprotein_ADH-like_supfam.)
IPR015943 (WD40/YVTN_repeat-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 4G31 4G34 4M7I 4X7H 4X7J 4X7K 4X7L 4X7N 4X7O 4YZS 5SV7
CREDO 4G31 4G34 4M7I 4X7H 4X7J 4X7K 4X7L 4X7N 4X7O 4YZS 5SV7