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Target Report Card

Target Name and Classification

Target ID CHEMBL6028
Preferred Name Segment polarity protein dishevelled homolog DVL-3
Synonyms DSH homolog 3 | DVL3 | Dishevelled-3 | KIAA0208 | Segment polarity protein dishevelled homolog DVL-3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Segment polarity protein dishevelled homolog DVL-3 SINGLE PROTEIN Q92997

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000161202
Ensembl ENSG00000161202
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0002020 (protease binding)
GO:0005102 (receptor binding)
GO:0005109 (frizzled binding)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0046982 (protein heterodimerization activity)
GO:0048365 (Rac GTPase binding)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0007275 (multicellular organism development)
GO:0016055 (Wnt signaling pathway)
GO:0035556 (intracellular signal transduction)
GO:0035567 (non-canonical Wnt signaling pathway)
GO:0038031 (non-canonical Wnt signaling pathway via JNK cascade)
GO:0042493 (response to drug)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0043547 (positive regulation of GTPase activity)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0050821 (protein stabilization)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060071 (Wnt signaling pathway, planar cell polarity pathway)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0090179 (planar cell polarity pathway involved in neural tube closure)
GO:0150012 (positive regulation of neuron projection arborization)
GO:1903827 (regulation of cellular protein localization)
GO:1904886 (beta-catenin destruction complex disassembly)
Wikipedia DVL3

Target Cross References - Protein

canSAR Q92997
Human Protein Atlas ENSG00000161202
IntAct Q92997
Open Targets ENSG00000161202
PharmGKB PA27543
Reactome R-HSA-201681 (TCF dependent signaling in response to WNT.)
R-HSA-201688 (WNT mediated activation of DVL.)
R-HSA-4086400 (PCP/CE pathway.)
R-HSA-4641258 (Degradation of DVL.)
R-HSA-4641262 (Disassembly of the destruction complex and recruitment of AXIN to the membrane.)
R-HSA-5368598 (Negative regulation of TCF-dependent signaling by DVL-interacting proteins.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
UniProt B4E3E5 D3DNT0 O14642 Q13531 Q8N5E9 Q92607 Q92997

Target Cross References - Domain

InterPro IPR000591 (DEP_dom.)
IPR001158 (DIX.)
IPR001478 (PDZ.)
IPR003351 (Dishevelled_protein_dom.)
IPR008339 (Dishevelled_fam.)
IPR008342 (DVL3.)
IPR015506 (Dsh/Dvl-rel.)
IPR024580 (Dishevelled_C-dom.)
IPR029071 (Ubiquitin-like_domsf.)
IPR036034 (PDZ_sf.)
IPR036388 (WH-like_DNA-bd_sf.)
IPR036390 (WH_DNA-bd_sf.)
Pfam PF00595 (PDZ)
PF00610 (DEP)
PF00778 (DIX)
PF02377 (Dishevelled)
PF12316 (Dsh_C)