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Target Report Card

Target Name and Classification

Target ID CHEMBL6006
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase ULK1
Synonyms ATG1 | Autophagy-related protein 1 homolog | KIAA0722 | Serine/threonine-protein kinase ULK1 | ULK1 | Unc-51-like kinase 1 | hATG1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase ulk family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase ULK1 SINGLE PROTEIN O75385

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000177169
Ensembl ENSG00000177169
GO Cellular Component GO:0000407 (pre-autophagosomal structure)
GO:0005737 (cytoplasm)
GO:0005741 (mitochondrial outer membrane)
GO:0005776 (autophagosome)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0030424 (axon)
GO:0032045 (guanyl-nucleotide exchange factor complex)
GO:0034045 (pre-autophagosomal structure membrane)
GO:0055037 (recycling endosome)
GO:0097629 (extrinsic component of omegasome membrane)
GO:0097632 (extrinsic component of pre-autophagosomal structure membrane)
GO:0097635 (extrinsic component of autophagosome membrane)
GO:1990316 (ATG1/ULK1 kinase complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017137 (Rab GTPase binding)
GO:0042802 (identical protein binding)
GO:0044877 (macromolecular complex binding)
GO:0051020 (GTPase binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006914 (autophagy)
GO:0007165 (signal transduction)
GO:0007409 (axonogenesis)
GO:0008104 (protein localization)
GO:0016236 (macroautophagy)
GO:0016241 (regulation of macroautophagy)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0031102 (neuron projection regeneration)
GO:0031175 (neuron projection development)
GO:0031333 (negative regulation of protein complex assembly)
GO:0031669 (cellular response to nutrient levels)
GO:0042594 (response to starvation)
GO:0046777 (protein autophosphorylation)
GO:0048675 (axon extension)
GO:0075044 (autophagy of host cells involved in interaction with symbiont)
GO:2000786 (positive regulation of autophagosome assembly)
Wikipedia ULK1

Target Cross References - Protein

Human Protein Atlas ENSG00000177169
IntAct O75385
Guide to Pharmacology 2271
Open Targets ENSG00000177169
PharmGKB PA37198
Pharos O75385 (Tchem)
Reactome R-HSA-1632852 (Macroautophagy.)
R-HSA-8854214 (TBC/RABGAPs.)
R-HSA-8876198 (RAB GEFs exchange GTP for GDP on RABs.)
R-HSA-8934903 (Receptor Mediated Mitophagy.)
UniProt O75385 Q9UQ28

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR016237 (Ser/Thr_kin_STPK_Ulk-1/2.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR022708 (Ser/Thr_kinase_C.)
Pfam PF00069 (Pkinase)
PF12063 (DUF3543)

Target Cross References - Structure

PDBe 4WNO 4WNP 5CI7
CREDO 4WNO 4WNP 5CI7
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