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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6000
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase RIO2
Synonyms RIO kinase 2 | RIOK2 | Serine/threonine-protein kinase RIO2 | Synonyms=RIO2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > atypical protein kinase group > atypical protein kinase rio family > atypical protein kinase rio2 subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase RIO2 SINGLE PROTEIN Q9BVS4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000058729
Ensembl ENSG00000058729
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0030688 (preribosome, small subunit precursor)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006364 (rRNA processing)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0016310 (phosphorylation)
GO:0030071 (regulation of mitotic metaphase/anaphase transition)
GO:0030490 (maturation of SSU-rRNA)
GO:0042254 (ribosome biogenesis)
GO:0042274 (ribosomal small subunit biogenesis)
GO:0046777 (protein autophosphorylation)
GO:2000208 (positive regulation of ribosomal small subunit export from nucleus)
GO:2000234 (positive regulation of rRNA processing)

Target Cross References - Protein

canSAR Q9BVS4
Human Protein Atlas ENSG00000058729
IntAct Q9BVS4
Guide to Pharmacology 2187
Open Targets ENSG00000058729
PharmGKB PA134885533
Pharos Q9BVS4 (Tbio)
Reactome R-HSA-6791226 (Major pathway of rRNA processing in the nucleolus and cytosol.)
UniProt D6RDI3 Q9BVS4 Q9NUT0

Target Cross References - Domain

InterPro IPR000687 (RIO_kinase.)
IPR011009 (Kinase-like_dom_sf.)
IPR015285 (RIO2_wHTH_N.)
IPR018935 (RIO_kinase_CS.)
IPR030484 (Rio2.)
IPR036388 (WH-like_DNA-bd_sf.)
IPR036390 (WH_DNA-bd_sf.)
Pfam PF09202 (Rio2_N)

Target Cross References - Structure

PDBe 5DHF
CREDO 5DHF
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