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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5988
Target Type SINGLE PROTEIN
Preferred Name Bcl-2-like protein 10
Synonyms Anti-apoptotic protein NrH | Apoptosis regulator Bcl-B | BCL2L10 | BCLB | Bcl-2-like protein 10 | Bcl2-L-10
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Bcl-2-like protein 10 SINGLE PROTEIN Q9HD36

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137875
Ensembl ENSG00000137875
GO Cellular Component GO:0005634 (nucleus)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031965 (nuclear membrane)
GO Molecular Function GO:0005515 (protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007283 (spermatogenesis)
GO:0007292 (female gamete generation)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0042981 (regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway)
Wikipedia BCL2L10

Target Cross References - Protein

canSAR Q9HD36
Human Protein Atlas ENSG00000137875
IntAct Q9HD36
Open Targets ENSG00000137875
PharmGKB PA25304
UniProt Q3SX80 Q52LQ9 Q8TCS9 Q9HD36

Target Cross References - Domain

InterPro IPR002475 (Bcl2-like.)
IPR020717 (Bcl2_BH1_motif_CS.)
IPR020726 (Bcl2_BH2_motif_CS.)
IPR026298 (Blc2_fam.)
Pfam PF00452 (Bcl-2)

Target Cross References - Structure

PDBe 4B4S
CREDO 4B4S
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