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Target Report Card

Target Name and Classification

Target ID CHEMBL5985
Target Type SINGLE PROTEIN
Preferred Name ADP-ribosylation factor 1
Synonyms ADP-ribosylation factor 1 | ARF1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
ADP-ribosylation factor 1 SINGLE PROTEIN P84077

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143761
Ensembl ENSG00000143761
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005770 (late endosome)
GO:0005778 (peroxisomal membrane)
GO:0005794 (Golgi apparatus)
GO:0005802 (trans-Golgi network)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0012505 (endomembrane system)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0030017 (sarcomere)
GO:0030054 (cell junction)
GO:0030137 (COPI-coated vesicle)
GO:0031252 (cell leading edge)
GO:0043005 (neuron projection)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0003924 (GTPase activity)
GO:0005057 (receptor signaling protein activity)
GO:0005515 (protein binding)
GO:0005525 (GTP binding)
GO:0019003 (GDP binding)
GO:0044822 (poly(A) RNA binding)
GO:1990583 (phospholipase D activator activity)
GO Biological Process GO:0002090 (regulation of receptor internalization)
GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0006810 (transport)
GO:0006878 (cellular copper ion homeostasis)
GO:0006892 (post-Golgi vesicle-mediated transport)
GO:0007015 (actin filament organization)
GO:0007264 (small GTPase mediated signal transduction)
GO:0015031 (protein transport)
GO:0016192 (vesicle-mediated transport)
GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
GO:0034315 (regulation of Arp2/3 complex-mediated actin nucleation)
GO:0034379 (very-low-density lipoprotein particle assembly)
GO:0043085 (positive regulation of catalytic activity)
GO:0045807 (positive regulation of endocytosis)
GO:0045956 (positive regulation of calcium ion-dependent exocytosis)
GO:0050690 (regulation of defense response to virus by virus)
GO:0050714 (positive regulation of protein secretion)
GO:0055108 (Golgi to transport vesicle transport)
GO:0060292 (long term synaptic depression)
GO:0060999 (positive regulation of dendritic spine development)
GO:0070142 (synaptic vesicle budding)
GO:0097061 (dendritic spine organization)
GO:0097212 (lysosomal membrane organization)
GO:1902307 (positive regulation of sodium ion transmembrane transport)
GO:1902824 (positive regulation of late endosome to lysosome transport)
GO:1902953 (positive regulation of ER to Golgi vesicle-mediated transport)
GO:1903725 (regulation of phospholipid metabolic process)
Wikipedia ARF1

Target Cross References - Protein

canSAR P84077
Human Protein Atlas ENSG00000143761
IntAct P84077
Open Targets ENSG00000143761
PharmGKB PA24934
Reactome R-HSA-1660514 (Synthesis of PIPs at the Golgi membrane.)
R-HSA-167590 (Nef Mediated CD4 Down-regulation.)
R-HSA-2132295 (MHC class II antigen presentation.)
R-HSA-421837 (Clathrin derived vesicle budding.)
R-HSA-432720 (Lysosome Vesicle Biogenesis.)
R-HSA-432722 (Golgi Associated Vesicle Biogenesis.)
R-HSA-6807878 (COPI-mediated anterograde transport.)
R-HSA-6811434 (COPI-dependent Golgi-to-ER retrograde traffic.)
R-HSA-6811438 (Intra-Golgi traffic.)
TIMBAL ARF1
UniProt P10947 P32889 P84077

Target Cross References - Domain

InterPro IPR005225 (Small_GTP-bd_dom.)
IPR006689 (Small_GTPase_ARF/SAR.)
IPR024156 (Small_GTPase_ARF.)
IPR027417 (P-loop_NTPase.)
Pfam PF00025 (Arf)

Target Cross References - Structure

PDBe 1HUR 1RE0 3O47 4HMY
CREDO 1HUR 1RE0 3O47 4HMY
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