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Target Report Card

Target Name and Classification

Target ID CHEMBL5982
Preferred Name ADAM9
Synonyms ADAM 9 | ADAM9 | Cellular disintegrin-related protein | Disintegrin and metalloproteinase domain-containing protein 9 | KIAA0021 | MCMP | MDC9 | MLTNG | Meltrin-gamma | Metalloprotease/disintegrin/cysteine-rich protein 9 | Myeloma cell metalloproteinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12b subfamily

Target Components

Component Description Relationship Accession
Disintegrin and metalloproteinase domain-containing protein 9 SINGLE PROTEIN Q13443

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168615
Ensembl ENSG00000168615
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0031233 (intrinsic component of external side of plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0005080 (protein kinase C binding)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0016787 (hydrolase activity)
GO:0017124 (SH3 domain binding)
GO:0043236 (laminin binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0006508 (proteolysis)
GO:0006509 (membrane protein ectodomain proteolysis)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007229 (integrin-mediated signaling pathway)
GO:0010042 (response to manganese ion)
GO:0016477 (cell migration)
GO:0030216 (keratinocyte differentiation)
GO:0033627 (cell adhesion mediated by integrin)
GO:0033630 (positive regulation of cell adhesion mediated by integrin)
GO:0033631 (cell-cell adhesion mediated by integrin)
GO:0034241 (positive regulation of macrophage fusion)
GO:0034612 (response to tumor necrosis factor)
GO:0034616 (response to laminar fluid shear stress)
GO:0042117 (monocyte activation)
GO:0042542 (response to hydrogen peroxide)
GO:0050714 (positive regulation of protein secretion)
GO:0051044 (positive regulation of membrane protein ectodomain proteolysis)
GO:0051088 (PMA-inducible membrane protein ectodomain proteolysis)
GO:0051384 (response to glucocorticoid)
GO:0051549 (positive regulation of keratinocyte migration)
GO:0051592 (response to calcium ion)
GO:0071222 (cellular response to lipopolysaccharide)
Wikipedia ADAM9

Target Cross References - Protein

canSAR Q13443
CGD Cone-rod dystrophy 9
Human Protein Atlas ENSG00000168615
IntAct Q13443
Guide to Pharmacology 1657
Open Targets ENSG00000168615
PharmGKB PA24534
Reactome R-HSA-1442490 (Collagen degradation.)
UniProt B7ZLN7 Q10718 Q13443 Q8NFM6

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR001590 (Peptidase_M12B.)
IPR001762 (Disintegrin_dom.)
IPR002870 (Peptidase_M12B_N.)
IPR006586 (ADAM_Cys-rich.)
IPR013032 (EGF-like_CS.)
IPR018358 (Disintegrin_CS.)
IPR024079 (MetalloPept_cat_dom_sf.)
IPR034027 (Reprolysin_adamalysin.)
IPR036436 (Disintegrin_dom_sf.)
Pfam PF00200 (Disintegrin)
PF01421 (Reprolysin)
PF01562 (Pep_M12B_propep)
PF08516 (ADAM_CR)