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Target Report Card

Target Name and Classification

Target ID CHEMBL5976
Preferred Name Heat shock protein beta-1
Synonyms 28 kDa heat shock protein | Estrogen-regulated 24 kDa protein | HSP 27 | HSP27 | HSP28 | HSPB1 | Heat shock 27 kDa protein | Heat shock protein beta-1 | HspB1 | SRP27 | Stress-responsive protein 27
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Heat shock protein beta-1 SINGLE PROTEIN P04792

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106211
Ensembl ENSG00000106211
GO Cellular Component GO:0000502 (proteasome complex)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0030018 (Z disc)
GO:0043292 (contractile fiber)
GO:0070062 (extracellular exosome)
GO:1904115 (axon cytoplasm)
GO Molecular Function GO:0003723 (RNA binding)
GO:0005080 (protein kinase C binding)
GO:0005515 (protein binding)
GO:0008426 (protein kinase C inhibitor activity)
GO:0019901 (protein kinase binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043130 (ubiquitin binding)
GO:0044183 (protein binding involved in protein folding)
GO Biological Process GO:0001895 (retina homeostasis)
GO:0001932 (regulation of protein phosphorylation)
GO:0006446 (regulation of translational initiation)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006986 (response to unfolded protein)
GO:0009615 (response to virus)
GO:0010506 (regulation of autophagy)
GO:0032731 (positive regulation of interleukin-1 beta production)
GO:0035556 (intracellular signal transduction)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0038033 (positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)
GO:0042535 (positive regulation of tumor necrosis factor biosynthetic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043488 (regulation of mRNA stability)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0045766 (positive regulation of angiogenesis)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0061077 (chaperone-mediated protein folding)
GO:0070527 (platelet aggregation)
GO:0071901 (negative regulation of protein serine/threonine kinase activity)
GO:0099641 (anterograde axonal protein transport)
GO:1902176 (negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)
GO:2001028 (positive regulation of endothelial cell chemotaxis)
GO:2001234 (negative regulation of apoptotic signaling pathway)
Wikipedia Hsp27

Target Cross References - Protein

canSAR P04792
CGD Neuropathy, distal hereditary motor, type IIB; Charcot-Marie-Tooth disease, axonal, type 2F
Human Protein Atlas ENSG00000106211
IntAct P04792
Open Targets ENSG00000106211
PharmGKB PA29511
Reactome R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-450408 (AUF1 (hnRNP D0) binds and destabilizes mRNA.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
UniProt B2R4N8 P04792 Q6FI47 Q96C20 Q96EI7 Q9UC31 Q9UC34 Q9UC35 Q9UC36

Target Cross References - Domain

InterPro IPR001436 (Alpha-crystallin/HSP.)
IPR002068 (A-crystallin/Hsp20_dom.)
IPR008978 (HSP20-like_chaperone.)
IPR031107 (HSP20.)
IPR037876 (ACD_HspB1.)
Pfam PF00011 (HSP20)

Target Cross References - Structure