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Target Report Card

Target Name and Classification

Target ID CHEMBL5970
Preferred Name Mitogen-activated protein kinase kinase kinase 3
Synonyms MAP3K3 | MAPK/ERK kinase kinase 3 | MAPKKK3 | MEK kinase 3 | MEKK 3 | MEKK3 | Mitogen-activated protein kinase kinase kinase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste11 family > ste protein kinase mekk2

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 3 SINGLE PROTEIN Q99759

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198909
Ensembl ENSG00000198909
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000186 (activation of MAPKK activity)
GO:0001568 (blood vessel development)
GO:0006468 (protein phosphorylation)
GO:0007346 (regulation of mitotic cell cycle)
GO:0016310 (phosphorylation)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0032147 (activation of protein kinase activity)
GO:0035556 (intracellular signal transduction)
GO:0042981 (regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0046777 (protein autophosphorylation)
GO:0070498 (interleukin-1-mediated signaling pathway)
GO:0071864 (positive regulation of cell proliferation in bone marrow)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:1900745 (positive regulation of p38MAPK cascade)
GO:2000773 (negative regulation of cellular senescence)
Wikipedia MAP3K3

Target Cross References - Protein

canSAR Q99759
Human Protein Atlas ENSG00000198909
IntAct Q99759
Guide to Pharmacology 2078
Open Targets ENSG00000198909
PharmGKB PA30599
Pharos Q99759 (Tchem)
Reactome R-HSA-9020702 (Interleukin-1 signaling.)
UniProt B2RCW2 D3DU15 Q5BKZ6 Q8N3I9 Q99759

Target Cross References - Domain

InterPro IPR000270 (PB1_dom.)
IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR034879 (PB1_MEKK2/3.)
Pfam PF00069 (Pkinase)
PF00564 (PB1)

Target Cross References - Structure

PDBe 2C60 2O2V 4Y5O 4YL6
CREDO 2C60 2O2V 4Y5O 4YL6