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Target Report Card

Target Name and Classification

Target ID CHEMBL5969
Preferred Name Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
Synonyms 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha | PIP5K1-alpha | PIP5K1A | PIP5KIalpha | Phosphatidylinositol 4-phosphate 5-kinase type I alpha | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha | PtdIns(4)P-5-kinase 1 alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase

Target Components

Component Description Relationship Accession
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha SINGLE PROTEIN Q99755

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143398
Ensembl ENSG00000143398
GO Cellular Component GO:0001726 (ruffle)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005847 (mRNA cleavage and polyadenylation specificity factor complex)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0016607 (nuclear speck)
GO:0030027 (lamellipodium)
GO:0032587 (ruffle membrane)
GO:0042995 (cell projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000285 (1-phosphatidylinositol-3-phosphate 5-kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016307 (phosphatidylinositol phosphate kinase activity)
GO:0016308 (1-phosphatidylinositol-4-phosphate 5-kinase activity)
GO:0016740 (transferase activity)
GO:0019900 (kinase binding)
GO:0052810 (1-phosphatidylinositol-5-kinase activity)
GO:0052811 (1-phosphatidylinositol-3-phosphate 4-kinase activity)
GO:0052812 (phosphatidylinositol-3,4-bisphosphate 5-kinase activity)
GO Biological Process GO:0006650 (glycerophospholipid metabolic process)
GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0006909 (phagocytosis)
GO:0007165 (signal transduction)
GO:0008654 (phospholipid biosynthetic process)
GO:0010761 (fibroblast migration)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0030216 (keratinocyte differentiation)
GO:0031532 (actin cytoskeleton reorganization)
GO:0046488 (phosphatidylinositol metabolic process)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048041 (focal adhesion assembly)
GO:0060326 (cell chemotaxis)
GO:0072659 (protein localization to plasma membrane)
GO:0090630 (activation of GTPase activity)
GO:0097178 (ruffle assembly)
Wikipedia PIP5K1A

Target Cross References - Protein

canSAR Q99755
Human Protein Atlas ENSG00000143398
IntAct Q99755
Guide to Pharmacology 2164
Open Targets ENSG00000143398
PharmGKB PA33327
Pharos Q99755 (Tbio)
Reactome R-HSA-1660499 (Synthesis of PIPs at the plasma membrane.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
UniProt A8K4Q0 B4DIN0 Q99754 Q99755 Q99756

Target Cross References - Domain

InterPro IPR002498 (PInositol-4-P-5-kinase_core.)
IPR023610 (PInositol-4-P-5-kinase.)
IPR027483 (PInositol-4-P-5-kinase_C.)
IPR027484 (PInositol-4-P-5-kinase_N.)
Pfam PF01504 (PIP5K)