ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL5947
Preferred Name Tyrosine aminotransferase
Synonyms L-tyrosine:2-oxoglutarate aminotransferase | TAT | Tat | Tyrosine aminotransferase
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Tyrosine aminotransferase SINGLE PROTEIN P04694

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004838 (L-tyrosine:2-oxoglutarate aminotransferase activity)
GO:0008483 (transaminase activity)
GO:0016597 (amino acid binding)
GO:0016740 (transferase activity)
GO:0030170 (pyridoxal phosphate binding)
GO:0080130 (L-phenylalanine:2-oxoglutarate aminotransferase activity)
GO Biological Process GO:0006094 (gluconeogenesis)
GO:0006103 (2-oxoglutarate metabolic process)
GO:0006520 (cellular amino acid metabolic process)
GO:0006536 (glutamate metabolic process)
GO:0006559 (L-phenylalanine catabolic process)
GO:0006572 (tyrosine catabolic process)
GO:0006979 (response to oxidative stress)
GO:0009058 (biosynthetic process)
GO:0009072 (aromatic amino acid family metabolic process)
GO:0009074 (aromatic amino acid family catabolic process)
GO:0014070 (response to organic cyclic compound)
GO:0046689 (response to mercury ion)
GO:0051384 (response to glucocorticoid)

Target Cross References - Protein

canSAR P04694
Reactome R-RNO-71182 (Phenylalanine and tyrosine catabolism.)
UniProt P04694 Q5EBB6

Target Cross References - Domain

InterPro IPR004838 (NHTrfase_class1_PyrdxlP-BS.)
IPR004839 (Aminotransferase_I/II.)
IPR005957 (Tyrosine_aminoTrfase.)
IPR005958 (TyrNic_aminoTrfase.)
IPR011715 (Tyr_aminoTrfase_ubiquitination.)
IPR015421 (PyrdxlP-dep_Trfase_major_sub1.)
IPR015422 (PyrdxlP-dep_Trfase_major_sub2.)
IPR015424 (PyrdxlP-dep_Trfase.)
Pfam PF00155 (Aminotran_1_2)
PF07706 (TAT_ubiq)