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Target Report Card

Target Name and Classification

Target ID CHEMBL5943
Target Type SINGLE PROTEIN
Preferred Name Beta-2 adrenergic receptor
Synonyms ADRB2 | Beta-2 adrenergic receptor | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Organism Mesocricetus auratus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-2 adrenergic receptor SINGLE PROTEIN P04274

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004941 (beta2-adrenergic receptor activity)
GO:0008179 (adenylate cyclase binding)
GO:0015459 (potassium channel regulator activity)
GO:0019899 (enzyme binding)
GO:0042803 (protein homodimerization activity)
GO:0044877 (macromolecular complex binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0001993 (regulation of systemic arterial blood pressure by norepinephrine-epinephrine)
GO:0002024 (diet induced thermogenesis)
GO:0002025 (vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure)
GO:0002028 (regulation of sodium ion transport)
GO:0002032 (desensitization of G-protein coupled receptor protein signaling pathway by arrestin)
GO:0006898 (receptor-mediated endocytosis)
GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0009409 (response to cold)
GO:0010739 (positive regulation of protein kinase A signaling)
GO:0030501 (positive regulation of bone mineralization)
GO:0031398 (positive regulation of protein ubiquitination)
GO:0031649 (heat generation)
GO:0040015 (negative regulation of multicellular organism growth)
GO:0043410 (positive regulation of MAPK cascade)
GO:0045453 (bone resorption)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0045986 (negative regulation of smooth muscle contraction)
GO:0050873 (brown fat cell differentiation)
GO:0061885 (positive regulation of mini excitatory postsynaptic potential)
GO:0071875 (adrenergic receptor signaling pathway)
GO:0071902 (positive regulation of protein serine/threonine kinase activity)
GO:0097746 (regulation of blood vessel diameter)
GO:1901098 (positive regulation of autophagosome maturation)
GO:1904504 (positive regulation of lipophagy)
GO:1904646 (cellular response to beta-amyloid)
GO:2000969 (positive regulation of AMPA receptor activity)

Target Cross References - Protein

canSAR P04274
UniProt P04274

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000332 (ADRB2_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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