ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL5938
Preferred Name Serine/threonine-protein kinase PLK2
Synonyms PLK-2 | PLK2 | Polo-like kinase 2 | SNK | Serine/threonine-protein kinase PLK2 | Serine/threonine-protein kinase SNK | Serum-inducible kinase | hPlk2 | hSNK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase plk family > other protein kinase plk2

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PLK2 SINGLE PROTEIN Q9NYY3

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145632
Ensembl ENSG00000145632
GO Cellular Component GO:0000785 (chromatin)
GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005814 (centriole)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0030425 (dendrite)
GO:0042995 (cell projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0043008 (ATP-dependent protein binding)
GO:0044877 (macromolecular complex binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000278 (mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0007052 (mitotic spindle organization)
GO:0007093 (mitotic cell cycle checkpoint)
GO:0007265 (Ras protein signal transduction)
GO:0007613 (memory)
GO:0010508 (positive regulation of autophagy)
GO:0016310 (phosphorylation)
GO:0016525 (negative regulation of angiogenesis)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0032092 (positive regulation of protein binding)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0032486 (Rap protein signal transduction)
GO:0043066 (negative regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045732 (positive regulation of protein catabolic process)
GO:0046599 (regulation of centriole replication)
GO:0048167 (regulation of synaptic plasticity)
GO:0060291 (long-term synaptic potentiation)
GO:0060292 (long term synaptic depression)
GO:0061000 (negative regulation of dendritic spine development)
GO:0071866 (negative regulation of apoptotic process in bone marrow)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:2000773 (negative regulation of cellular senescence)
Wikipedia PLK2

Target Cross References - Protein

Human Protein Atlas ENSG00000145632
IntAct Q9NYY3
Guide to Pharmacology 2169
Open Targets ENSG00000145632
PharmGKB PA134940798
Pharos Q9NYY3 (Tchem)
Reactome R-HSA-6804115 (TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.)
UniProt O60679 Q96CV7 Q9NYY3 Q9UE61

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000959 (POLO_box_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR033695 (POLO_box_2.)
IPR033701 (POLO_box_1.)
IPR036947 (POLO_box_dom_sf.)
Pfam PF00069 (Pkinase)
PF00659 (POLO_box)

Target Cross References - Structure

PDBe 4I5M 4I5P 4I6B 4I6F 4I6H 4RS6 4XB0
CREDO 4I5M 4I5P 4I6B 4I6F 4I6H 4RS6 4XB0