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Target Report Card

Target Name and Classification

Target ID CHEMBL5918
Preferred Name Canalicular multispecific organic anion transporter 2
Synonyms ABCC3 | ATP-binding cassette sub-family C member 3 | CMOAT2 | Canalicular multispecific organic anion transporter 2 | MLP2 | MOAT-D | MRP3 | Multi-specific organic anion transporter D | Multidrug resistance-associated protein 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcc subfamily

Target Components

Component Description Relationship Accession
Canalicular multispecific organic anion transporter 2 SINGLE PROTEIN O15438

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000108846
Ensembl ENSG00000108846
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005524 (ATP binding)
GO:0008514 (organic anion transmembrane transporter activity)
GO:0008559 (xenobiotic-transporting ATPase activity)
GO:0015432 (bile acid-exporting ATPase activity)
GO:0016887 (ATPase activity)
GO:0022857 (transmembrane transporter activity)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
GO:0043225 (anion transmembrane-transporting ATPase activity)
GO Biological Process GO:0006855 (drug transmembrane transport)
GO:0015721 (bile acid and bile salt transport)
GO:0015722 (canalicular bile acid transport)
GO:0042908 (xenobiotic transport)
GO:0055085 (transmembrane transport)
GO:0099133 (ATP hydrolysis coupled anion transmembrane transport)
Wikipedia ABCC3

Target Cross References - Protein

canSAR O15438
Human Protein Atlas ENSG00000108846
IntAct O15438
Open Targets ENSG00000108846
PharmGKB PA376
Reactome R-HSA-159418 (Recycling of bile acids and salts.)
R-HSA-382556 (ABC-family proteins mediated transport.)
UniProt B2RPA9 D3DTX9 O15438 O60265 O60922 O75621 O95078 O95289 O95290 Q86X85 Q9UN52

Target Cross References - Domain

InterPro IPR003439 (ABC_transporter-like.)
IPR003593 (AAA+_ATPase.)
IPR005292 (Multidrug-R_assoc.)
IPR011527 (ABC1_TM_dom.)
IPR017871 (ABC_transporter_CS.)
IPR027417 (P-loop_NTPase.)
IPR036640 (ABC1_TM_sf.)
Pfam PF00005 (ABC_tran)
PF00664 (ABC_membrane)