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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5914
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase kinase kinase 2
Synonyms MAP3K2 | MAPK/ERK kinase kinase 2 | MAPKKK2 | MEK kinase 2 | MEKK 2 | MEKK2 | Mitogen-activated protein kinase kinase kinase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste11 family > ste protein kinase mekk2

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 2 SINGLE PROTEIN Q9Y2U5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169967
Ensembl ENSG00000169967
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0000187 (activation of MAPK activity)
GO:0006468 (protein phosphorylation)
GO:0007257 (activation of JUN kinase activity)
GO:0007346 (regulation of mitotic cell cycle)
GO:0016310 (phosphorylation)
GO:0042981 (regulation of apoptotic process)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0071260 (cellular response to mechanical stimulus)
Wikipedia MAP3K2

Target Cross References - Protein

canSAR Q9Y2U5
Human Protein Atlas ENSG00000169967
IntAct Q9Y2U5
Guide to Pharmacology 2077
Open Targets ENSG00000169967
PharmGKB PA30598
Pharos Q9Y2U5 (Tchem)
UniProt B9EG87 Q53QL9 Q53S75 Q59GZ6 Q8NC32 Q9NYK3 Q9Y2U5

Target Cross References - Domain

InterPro IPR000270 (PB1_dom.)
IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR034879 (PB1_MEKK2/3.)
Pfam PF00069 (Pkinase)
PF00564 (PB1)

Target Cross References - Structure

PDBe 2NPT 5EX0 5HQ8
CREDO 2NPT 5EX0 5HQ8
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