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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5907
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase LATS2
Synonyms KPM | Kinase phosphorylated during mitosis protein | LATS2 | Large tumor suppressor homolog 2 | Serine/threonine-protein kinase LATS2 | Serine/threonine-protein kinase kpm | Warts-like kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase ndr family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase LATS2 SINGLE PROTEIN Q9NRM7

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000150457
Ensembl ENSG00000150457
GO Cellular Component GO:0000922 (spindle pole)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0009755 (hormone-mediated signaling pathway)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0035329 (hippo signaling)
GO:0035556 (intracellular signal transduction)
GO:0043065 (positive regulation of apoptotic process)
GO:0045736 (negative regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0046620 (regulation of organ growth)
GO:0051301 (cell division)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
Wikipedia LATS2

Target Cross References - Protein

canSAR Q9NRM7
Human Protein Atlas ENSG00000150457
IntAct Q9NRM7
Guide to Pharmacology 1516
Open Targets ENSG00000150457
PharmGKB PA30302
Pharos Q9NRM7 (Tchem)
Reactome R-HSA-2028269 (Signaling by Hippo.)
UniProt B1AM47 Q9NRM7 Q9P2X1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR009060 (UBA-like_sf.)
IPR011009 (Kinase-like_dom_sf.)
IPR015940 (UBA.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 4ZRI
CREDO 4ZRI
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