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Target Report Card

Target Name and Classification

Target ID CHEMBL5905
Target Type SINGLE PROTEIN
Preferred Name Aldo-keto reductase family 1 member C1
Synonyms 20-alpha-HSD | 20-alpha-hydroxysteroid dehydrogenase | AKR1C1 | Aldo-keto reductase family 1 member C1 | Chlordecone reductase homolog HAKRC | DD1/DD2 | DDH | DDH1 | Dihydrodiol dehydrogenase 1/2 | HBAB | High-affinity hepatic bile acid-binding protein | Indanol dehydrogenase | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldo-keto reductase family 1 member C1 SINGLE PROTEIN Q04828

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000187134
Ensembl ENSG00000187134
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004032 (alditol:NADP+ 1-oxidoreductase activity)
GO:0004033 (aldo-keto reductase (NADP) activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor)
GO:0018636 (phenanthrene 9,10-monooxygenase activity)
GO:0031406 (carboxylic acid binding)
GO:0032052 (bile acid binding)
GO:0047006 (17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity)
GO:0047042 (androsterone dehydrogenase (B-specific) activity)
GO:0047086 (ketosteroid monooxygenase activity)
GO:0047115 (trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity)
GO:0047718 (indanol dehydrogenase activity)
GO Biological Process GO:0001523 (retinoid metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0007586 (digestion)
GO:0008206 (bile acid metabolic process)
GO:0015721 (bile acid and bile salt transport)
GO:0030299 (intestinal cholesterol absorption)
GO:0030855 (epithelial cell differentiation)
GO:0042448 (progesterone metabolic process)
GO:0042574 (retinal metabolic process)
GO:0042632 (cholesterol homeostasis)
GO:0044597 (daunorubicin metabolic process)
GO:0044598 (doxorubicin metabolic process)
GO:0046683 (response to organophosphorus)
GO:0051260 (protein homooligomerization)
GO:0055114 (oxidation-reduction process)
GO:0071395 (cellular response to jasmonic acid stimulus)
Wikipedia AKR1C1

Target Cross References - Protein

canSAR Q04828
Human Protein Atlas ENSG00000187134
IntAct Q04828
Open Targets ENSG00000187134
PharmGKB PA24677
Reactome R-HSA-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-HSA-193775 (Synthesis of bile acids and bile salts via 24-hydroxycholesterol.)
R-HSA-193807 (Synthesis of bile acids and bile salts via 27-hydroxycholesterol.)
R-HSA-975634 (Retinoid metabolism and transport.)
UniProt P52896 Q04828 Q5SR15 Q7M4N2 Q9UCX2

Target Cross References - Domain

InterPro IPR018170 (Aldo/ket_reductase_CS.)
IPR020471 (Aldo/keto_reductase.)
IPR023210 (NADP_OxRdtase_dom.)
Pfam PF00248 (Aldo_ket_red)

Target Cross References - Structure

PDBe 1MRQ 3C3U 3GUG 3NTY 4YVP
CREDO 1MRQ 3C3U 3GUG 3NTY 4YVP
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