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Target Report Card

Target Name and Classification

Target ID CHEMBL5903
Target Type SINGLE PROTEIN
Preferred Name Activin receptor type-1
Synonyms ACTR-I | ACVR1 | ACVRLK2 | ALK-2 | Activin receptor type I | Activin receptor type-1 | Activin receptor-like kinase 2 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr1

Target Components

Component Description Relationship Accession
Activin receptor type-1 SINGLE PROTEIN Q04771

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115170
Ensembl ENSG00000115170
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0045177 (apical part of cell)
GO:0048179 (activin receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004675 (transmembrane receptor protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005025 (transforming growth factor beta receptor activity, type I)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016361 (activin receptor activity, type I)
GO:0016740 (transferase activity)
GO:0017046 (peptide hormone binding)
GO:0019838 (growth factor binding)
GO:0042803 (protein homodimerization activity)
GO:0046332 (SMAD binding)
GO:0046872 (metal ion binding)
GO:0048185 (activin binding)
GO:0050431 (transforming growth factor beta binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0001569 (patterning of blood vessels)
GO:0001701 (in utero embryonic development)
GO:0001702 (gastrulation with mouth forming second)
GO:0001707 (mesoderm formation)
GO:0001755 (neural crest cell migration)
GO:0002526 (acute inflammatory response)
GO:0003143 (embryonic heart tube morphogenesis)
GO:0003183 (mitral valve morphogenesis)
GO:0003289 (atrial septum primum morphogenesis)
GO:0006468 (protein phosphorylation)
GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007281 (germ cell development)
GO:0007368 (determination of left/right symmetry)
GO:0007369 (gastrulation)
GO:0007498 (mesoderm development)
GO:0007507 (heart development)
GO:0009968 (negative regulation of signal transduction)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030278 (regulation of ossification)
GO:0030335 (positive regulation of cell migration)
GO:0030501 (positive regulation of bone mineralization)
GO:0030509 (BMP signaling pathway)
GO:0032924 (activin receptor signaling pathway)
GO:0032926 (negative regulation of activin receptor signaling pathway)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051145 (smooth muscle cell differentiation)
GO:0060037 (pharyngeal system development)
GO:0060389 (pathway-restricted SMAD protein phosphorylation)
GO:0060923 (cardiac muscle cell fate commitment)
GO:0061445 (endocardial cushion cell fate commitment)
GO:0071385 (cellular response to glucocorticoid stimulus)
GO:0071773 (cellular response to BMP stimulus)
GO:2000017 (positive regulation of determination of dorsal identity)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
Wikipedia ACVR1

Target Cross References - Protein

canSAR Q04771
CGD Fibrodysplasia ossificans progressiva
Human Protein Atlas ENSG00000115170
IntAct Q04771
Guide to Pharmacology 1785
Open Targets ENSG00000115170
PharmGKB PA24492
Pharos Q04771 (Tchem)
UniProt Q04771

Target Cross References - Domain

InterPro IPR000333 (TGFB_receptor.)
IPR000472 (Activin_recp.)
IPR000719 (Prot_kinase_dom.)
IPR003605 (GS_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF01064 (Activin_recp)
PF08515 (TGF_beta_GS)

Target Cross References - Structure

PDBe 3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM
CREDO 3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM
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